TCR Sequencing Can Identify and Track Glioma-Infiltrating T Cells after DC Vaccination

Melody S. Hsu1,2, Shaina Sedighim1, Tina Wang1,3, Joseph P. Antonios1,4, Richard G. Everson1, Alexander M. Tucker1, Lin Du5, Ryan Emerson6, Erik Yusko6, Catherine Sanders6, Harlan S. Robins6,7, William H. Yong8,9, Tom B. Davidson1,2,8, Gang Li5,8, Linda M. Liau1,8, and Robert M. Prins1,8,10, 1Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California. 2Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California. 3Department of Medicine (Hematology/Oncology), David Geffen School of Medicine at UCLA, Los Angeles, California. 4Medical Scientist Training Program, David Geffen School of Medicine at UCLA, Los Angeles, California. 5Department of Biostatistics, David Geffen School of Medicine at UCLA, Los Angeles, California. 6Adaptive Biotechnologies, Seattle, Washington. 7Fred Hutchinson Cancer Research Center, Seattle, Washington. 8Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California. 9Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California. 10Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.