T lymphocytes are responsible for cellular immunity. They recognize cancer cells and cells that have been infected by a foreign pathogen.
B lymphocytes are antibody producing cells that mediate humoral immunity providing the primary defense to extracellular microbes.
Multiprotein complexes expressed on the surface of T or B cells that uniquely recognize antigen(s) in conjunction with invariant accessory proteins.
The immense diversity and specificity of antigen receptors are the result of recombining distinct V, D, and J gene segments.
Chromosomes are made up of tightly coiled DNA and are located in the nucleus of cells. Healthy cells have 23 pair of chromosomes.
immunoSEQ® Platform Technology
An overview of the immunoSEQ Assay technology describing the PCR amplification bias control and high throughput sequencing used to identify millions of T- and B-cell receptors in a single sample.
Behind the Technology
Learn more about the science behind Adaptive Biotechnologies.
How T-cells Work
Learn more about how T-cells work within the immune system.
HOW IT WORKS
immunoSEQ Assays give researchers a high-definition view of the adaptive immune system. It’s now possible to explore broad characteristics of T-and B-cell repertoires as well as the unique details of individual clones. Whether you are investigating the general trends of the immune system or specific clones, you can be confident in your data with the quantitative and reproducible results of immunoSEQ Assays behind your research.
Employing highly optimized PCR primers and a synthetic immune repertoire with computational algorithms, the immunoSEQ Assay delivers accurate, quantifiable results.
U.S. Patent Nos. 9,150,905 and 9,371,558
Primer concentrations adjusted to significantly reduce PCR amplification bias
Built-in controls assessed with every sample for true quantification
Corrects residual PCR amplification bias and quantifies T-cell or B-cell clones