Patents and Trademarks

Adaptive’s patent portfolio includes the following issued U.S. patents:

• U.S. Patent No. 8,236,503, entitled “Methods of Monitoring Conditions by Sequence Analysis”
• U.S. Patent No. 8,507,205, entitled “Single Cell Analysis by Polymerase Cycling Assembly”
• U.S. Patent No. 8,628,927, entitled “Monitoring Health and Disease Status Using Clonotype Profiles”
• U.S. Patent No. 8,685,898, entitled “Adaptive Immunity Profiling and Methods for Generation of Monoclonal Antibodies”
• U.S. Patent No. 8,691,510, entitled “Sequence Analysis of Complex Amplicons”
• U.S. Patent No. 8,748,103, entitled “Monitoring Health and Disease Status Using Clonotype Profiles”
• U.S. Patent No. 8,795,970, entitled “Methods of Monitoring Conditions by Sequence Analysis”
• U.S. Patent No. 8,883,418, entitled “Measurement of The Immunological Diversity and Evaluation of the Effects of a Treatment Through Studying V(D)J Diversity”
• U.S. Patent No. 9,043,160, entitled “Method of Determining Clonotypes and Clonotype Profiles”
• U.S. Patent No. 9,150,905, entitled “Compositions and Method for Measuring and Calibrating Amplification Bias in Multiplexed PCR Reactions”
• U.S. Patent No. 9,181,590, entitled “Quantification of Adaptive Immune Cell Genomes in a Complex Mixture Of Cells”
• U.S. Patent No. 9,181,591, entitled “Quantification of Adaptive Immune Cell Genomes in a Complex Mixture Of Cells”
• U.S. Patent No. 9,217,176 entitled “Methods of Monitoring Conditions by Sequence Analysis”
• U.S. Patent No. 9,228,232 entitled “Methods of Monitoring Conditions by Sequence Analysis”
• U.S. Patent No. 9,279,159 entitled “Quantification of Adaptive Immune Cell Genomes in a Complex Mixture of Cells”
• U.S. Patent No. 9,347,099 entitled “Single Cell Analysis by Polymerase Cycling Assembly”
• U.S. Patent No. 9,365,901 entitled “Monitoring Immunoglobulin Heavy Chain Evolution in B-cell Acute Lymphoblastic Leukemia”
• U.S. Patent No. 9,371,558 entitled “Compositions and Method for Measuring and Calibrating Amplification Bias in Multiplexed PCR Reactions”
• U.S. Patent No. 9,394,567 entitled “Detection and Quantification of Sample Contamination in Immune Repertoire Analysis”
• U.S. Patent No. 9,416,420 entitled “Monitoring Health and Disease Status Using Clonotype Profiles”
• U.S. Patent No. 9,499,865 entitled “Detection and Measurement of Tissue-Infiltrating Lymphocytes”
• U.S. Patent No. 9,506,119 entitled “Method of Sequence Determination Using Sequence Tags”
• U.S. Patent No. 9,512,487 entitled “Monitoring Health and Disease Status Using Clonotype Profiles”
• U.S. Patent No. 9,523,129 entitled “Sequence Analysis of Complex Amplicons”
• U.S. Patent No. 9,528,160 entitled “Rare Clonotypes and Uses Thereof”
• U.S. Patent No. 9,708,657, entitled “Method for Generating Clonotype Profiles Using Sequence Tags”
• U.S. Patent No. 9,809,813, entitled “Method of Measuring Adaptive Immunity”, exclusively licensed from the Fred Hutchinson Cancer Research Center”
• U.S. Patent No. 9,824,179, entitled “Diagnosis of Lymphoid Malignancies and Minimal Residual Disease Detection”
• U.S. Patent No. 10,066,265 entitled “Determining Antigen-Specific T-Cells”
• U.S. Patent No. 10,077,473 entitled “Method For Genotyping Clonotype Profiles Using Sequence Tags”
• U.S. Patent No. 10,077,478 entitled “Determining Paired Immune Receptor Chains From Frequency Matched Subunits”
• U.S. Patent No. 10,150,996 entitled “Quantification of Adaptive Immune Cell Genomes in a Complex Mixture of Cells”
• U.S. Patent No. 10,155,992 entitled “Monitoring Health and Disease Status Using Clonotype Profiles”
• U.S. Patent No. 10,214,770 entitled “Compositions and Method for Measuring and Calibrating Amplification Bias in Multiplexed PCR Reactions”
• U.S. Patent No. 10,221,461 entitled “Immunocompetence Assessment by Adaptive Immune Receptor Diversity and Clonality Characterization”
• U.S. Patent No. 10,246,701 entitled “Multiplexed Digital Quantitation of Rearranged Lymphoid Receptors in a complex Mixture”
• U.S. Patent No. 10,246,752 entitled “Methods of Monitoring Conditions By Sequence Analysis”
• U.S. Patent No. 10,266,901 entitled “Methods of Monitoring Conditions By Sequence Analysis”
• U.S. Patent No. 10,323,276 entitled “Adaptive Immunity Profiling and Methods for Generation of Monoclonal Antibodies”
• U.S. Patent No. 10,385,475 entitled “Random Array Sequencing of Low-Complexity Libraries”
• U.S. Patent No. 10,392,663 entitled “Highly-Multiplexed Simultaneous Detection of Nucleic Acids Encoding Paired Adaptive Immune Receptor Heterodimers from a Large Number of Samples”
• U.S. Patent No. 10,428,325 entitled “Identification of Antigen-Specific B Cell Receptors”
• U.S. Patent No. 10,435,745 entitled “Determining Antigen-Specific T-Cells”
• U.S. Patent No. 10,519,511 entitled “Monitoring Health and Disease Status Using Clonotype Profiles”
• U.S. Patent No. 10,526,650 entitled “Method for Genotyping Clonotype Profiles Using Sequence Tags”
• U.S. Patent No. 10,760,133 entitled “Monitoring Health and Disease Status Using Clonotype Profiles”
• U.S. Patent No. 10,865,453 entitled “Monitoring Health and Disease Status Using Clonotype Profiles”
• U.S. Patent No. 10,894,977 entitled “Compositions and Methods for Measuring and Calibrating Amplification Bias In Multiplexed PCR Reactions”
• U.S. Patent No. 11,001,895 entitled “Methods of Monitoring Conditions by Sequence Analysis”
• U.S. Patent No. 11,021,757 entitled “Monitoring Health and Disease Status Using Clonotype Profiles”

The following are trademarks of Adaptive Biotechnologies, including marks which are owned, registered or pending registration within and outside of the U.S.: ADAPTIVE and logo, ADAPTIVE BIOTECHNOLOGIES and logo, our A logo, our platform technology logo, immunoSEQ and logo, immunoSEQ TMAP COVID, T-Detect, ImmuneCODE, clonoSEQ and logo, ADAPTIVE ASSIST and logo, AMPLIFY ANSWERS, AMPLIFY DISCOVERY, AMPLIFY IMMUNOLOGY, Data with depth. Results with relevance., IMMUNEACCESS, MIRA, pairSEQ, truTCR, What gets measured gets managed, TruAb, ImmuneSense and SPEAKING THE YOUNIVERSAL LANGUAGE.