Neutralizing Antibodies

Adaptive has partnered with Amgen to discover and develop fully human neutralizing antibodies against SARS-CoV-2, aiming to help solve the current global pandemic by combining our immune medicine platform with Amgen’s leading antibody engineering capabilities. Neutralizing antibodies may be used therapeutically to treat someone currently fighting the disease and provide passive immunity to people who have recently been exposed to SARS-CoV-2.

Cancer Cellular Therapy

Adaptive has partnered with Genentech, a member of the Roche Group, to develop, manufacture, and commercialize novel neoantigen directed T-cell therapies for the treatment of a broad range of cancers. We aim to build a transformational new treatment paradigm of tailoring cellular therapy for each patient’s individual cancer.

TCR-Antigen Map

Adaptive has partnered with Microsoft to map and decode the human immune system, nature’s most finely tuned diagnostic. The ultimate goal is to potentially develop a diagnostic product that may enable early detection of multiple diseases from a single blood test.

 Biopharmaceutical Partners

Adaptive works with over 165 biopharmaceutical partners in hundreds of trials per year across the research and development value chain to incorporate proven immune-driven metrics and screening capabilities into translational analyses, diagnostic tools and drug discovery efforts. We work collaboratively to elucidate mechanism of action and dosing for earlier phase clinical trials, identify biomarkers of efficacy or adverse events for later stage trials, and screen for drug candidates that utilize or leverage the acumen of the immune system. In all our partnering models, Adaptive provides end-to-end support including hypothesis-driven trial design, extensive data analyses, parallel regulatory support, compliant data transfers, and novel target screening.

 Strategic Collaborators

Adaptive works with academic investigators, government-sponsored scientific institutions, and cooperative research organizations globally to incorporate immune profiling into high-impact research and clinical trials across disease settings. We work closely with teams on study design, sequencing, data analysis, and publication, with the overall goal of using immune repertoire dynamics to understand disease and host interactions, stratify patient populations, determine potential biomarkers of drug response, and ultimately improve patient outcomes.