Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections

Heather R. Conti,1 Alanna C. Peterson,1 Lucas Brane,1 Anna R. Huppler,5Nydiaris Hernández-Santos,1 Natasha Whibley,1 Abhishek V. Garg,1Michelle R. Simpson-Abelson,1 Gregory A. Gibson,4 Anna J. Mamo,1Lisa C. Osborne,6 Shrinivas Bishu,2 Nico Ghilardi,7 Ulrich Siebenlist,8Simon C. Watkins,4 David Artis,6 Mandy J. McGeachy,1,3 and Sarah L. Gaffen1,3 1Division of Rheumatology and Clinical Immunology, and 2Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, 3Department of Immunology, and 4Center for Biological Imaging, University of Pittsburgh, Pittsburgh, PA 15261, 5Department of Infectious Diseases, Children’s Hospital of Pittsburgh, Pittsburgh, PA 15224, 6Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. 7Department of Immunology, Genentech Inc., South San Francisco, CA 94080, 8Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852