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Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown

Reuschle Q, et al.
Journal of Autoimmunity
December 2023
Authors and Affiliates
Quentin Reuschlé 1, Laurien Van Heddegem 2, Victor Bosteels 2, Matthieu Moncan 3, Sabine Depauw 4, Nadège Wadier 4, Sandra Maréchal 2, Clint De Nolf 5, Virginia Delgado 4, Yosra Messai 6, Marie-Claude Stolzenberg 3, Aude Magérus 3, Angélique Werck 7, Jérôme Olagne 8, Quan Li 9, Guillaume Lefevre 10, Anne-Sophie Korganow 11, Frédéric Rieux-Laucat 3, Sophie Janssens 2, Pauline Soulas-Sprauel 12; 1 Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, F-67000, Strasbourg, France; Strasbourg University, Faculty of Pharmacy and Faculty of Medicine, Strasbourg, France; Arthritis R&D, Neuilly sur Seine, France. 2 Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium. 3 Université Paris Cité, Laboratoire d'immunogénétique des maladies auto-immunes pédiatriques, Institut Imagine, INSERM UMR_S1163, Paris, France. 4 Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, F-67000, Strasbourg, France; Strasbourg University, Faculty of Pharmacy and Faculty of Medicine, Strasbourg, France. 5 Laboratory for ER Stress and Inflammation, VIB Center for Inflammation Research, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Barriers in Inflammation, VIB Center for Inflammation Research, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. 6 Arthritis R&D, Neuilly sur Seine, France. 7 Department of Pathology, University Hospital, Strasbourg, France. 8 Department of Pathology, University Hospital, Strasbourg, France; Department of Adult Nephrology, University Hospital, Strasbourg, France. 9 Department of Immunology, UT Southwestern Medical Center, Dallas, TX, USA. 10 Inserm, U1286 - INFINITE - Institute for Translational Research in Inflammation, University of Lille, CHU Lille, Lille, France. 11 Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, F-67000, Strasbourg, France; Strasbourg University, Faculty of Pharmacy and Faculty of Medicine, Strasbourg, France; Department of Clinical Immunology and Internal Medicine, National Reference Center for Systemic Autoimmune Diseases (CNR RESO), Tertiary Center for Primary Immunodeficiency, Strasbourg University Hospital, F-67000, Strasbourg, France. 12 Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, F-67000, Strasbourg, France; Strasbourg University, Faculty of Pharmacy and Faculty of Medicine, Strasbourg, France; Department of Clinical Immunology and Internal Medicine, National Reference Center for Systemic Autoimmune Diseases (CNR RESO), Tertiary Center for Primary Immunodeficiency, Strasbourg University Hospital, F-67000, Strasbourg, France. Electronic address: soulaspa@unistra.fr.

Recruitment of naïve CD4+ T cells by the recombinant zoster vaccine correlates with persistent immunity

Laing KJ, et al.
Journal of Clinical Investigation
November 2023
Authors and Affiliates
Kerry J Laing 1, Emily S Ford 1, Michael J Johnson 2, Myron J Levin 3, David M Koelle 1, Adriana Weinberg 2; 1 Department of Medicine, University of Washington, Seattle, United States of America. 2 Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, United States of America. 3 Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, United States of America.

Post-vaccination SARS-Cov-2 T-cell receptor repertoires in patients with multiple sclerosis and related disorders

Algu P, et al.
Multiple Sclerosis and Related Disorders
October 2023
Authors and Affiliates
Priyanka Algu 1, Natasha Hameed 2, Tracy DeAngelis 3, Joel Stern 4, Asaff Harel 5; 1 Zucker School of Medicine at Hofstra/Northwell, 173 Lawrence St., New Hyde Park, NY 11040, United States. 2 Northwell Multiple Sclerosis Center, 611 Northern Blvd, Great Neck, NY 11021, United States. 3 Neurological Associates of Long Island, 1991 Marcus Ave, New Hyde Park, NY 11042, United States. 4 Northwell Multiple Sclerosis Center, 350 Community Drive, Manhasset NY 11030, United States. 5 Northwell Multiple Sclerosis Center, 130 East 77th Street, 8 Black Hall, NY 10075, United States. Electronic address: aharel@northwell.edu.

Immunosequencing and Profiling of T Cells at the Maternal-Fetal Interface of Women with Preterm Labor and Chronic Chorioamnionitis

Miller D, et al.
Journal of Immunology
October 2023
immuneAccess
Authors and Affiliates
Derek Miller 1,2, Roberto Romero 1,3,4, Luke Myers 5, Yi Xu 1,2, Marcia Arenas-Hernandez 1,2, Jose Galaz 1,2,6, Cinque Soto 5,7, Bogdan Done 1,2, Angelica Quiroz 1, Awoniyi O Awonuga 2, David R Bryant 2, Adi L Tarca 1,2,8,9, Nardhy Gomez-Lopez 1,2,10,9; 1 Pregnancy Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD. 2 Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI. 3 Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI. 4 Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI. 5 Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN. 6 Division of Obstetrics and Gynecology, Faculty of Medicine, Pontificial Catholic University of Chile, Santiago, Chile. 7 Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN. 8 Department of Computer Science, Wayne State University College of Engineering, Detroit, MI. 9 Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI. 10 Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI.

mRNA vaccination boosts S-specific T cell memory and promotes expansion of CD45RAint TEMRA-like CD8+ T cells in COVID-19 recovered individuals

Mayer-Blackwell K, et al.
Cell Reports Medicine
August 2023
Authors and Affiliates
Koshlan Mayer-Blackwell 1, Heeju Ryu 1, Amy S Codd 1, K Rachael Parks 1, Hugh R MacMillan 1, Kristen W Cohen 1, Terri L Stewart 1, Aaron Seese 1, Maria P Lemos 1, Stephen C De Rosa 1, Julie L Czartoski 1, Zoe Moodie 1, Long T Nguyen 1, Donald J McGuire 2, Rafi Ahmed 2, Andrew Fiore-Gartland 1, M Juliana McElrath 3, Evan W Newell 4; 1 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. 2 Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA. 3 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. Electronic address: jmcelrat@fredhutch.org. 4 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. Electronic address: enewell@fredhutch.org.

Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells

Malle L, et al.
Nature
August 2023
Authors and Affiliates
Louise Malle 1,2,3,4,5, Roosheel S Patel 1,2,3,4,5, Marta Martin-Fernandez 1,2,3,4,5, O Jay Stewart 1,2,3,4,5, Quentin Philippot 6,7, Sofija Buta 1,2,3,4,5, Ashley Richardson 1,2,3,4,5, Vanessa Barcessat 4, Justin Taft 1,2,3,4,5, Paul Bastard 6,7,8,9, Julie Samuels 3, Clotilde Mircher 10, Anne-Sophie Rebillat 10, Louise Maillebouis 10, Marie Vilaire-Meunier 10, Kevin Tuballes 4, Brad R Rosenberg 5, Rebecca Trachtman 2,3, Jean-Laurent Casanova 6,7,8,11,12, Luigi D Notarangelo 13, Sacha Gnjatic 4, Douglas Bush 2, Dusan Bogunovic 14,15,16,17,18; 1 Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 2 Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 3 Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 4 Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 5 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 6 Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France. 7 University of Paris, Imagine Institute, Paris, France. 8 St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. 9 Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France. 10 Institut Jérôme Lejeune, Paris, France. 11 Department of Pediatrics, Necker Hospital for Sick Children, Paris, France. 12 Howard Hughes Medical Institute, New York, NY, USA. 13 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 14 Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Dusan.Bogunovic@mssm.edu. 15 Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Dusan.Bogunovic@mssm.edu. 16 Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Dusan.Bogunovic@mssm.edu. 17 Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Dusan.Bogunovic@mssm.edu. 18 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Dusan.Bogunovic@mssm.edu.

COVID-19 Vaccine Response in People with Multiple Sclerosis Treated with Dimethyl Fumarate, Diroximel Fumarate, Natalizumab, Ocrelizumab, or Interferon Beta Therapy

Jaber A, et al.
Neurology and Therapy
August 2023
Authors and Affiliates
Aliya Jaber 1, Meera Patel 1, Andrew Sylvester 1, Mary Yarussi 1, J Tamar Kalina 2, Jason P Mendoza 2, Robin L Avila 2, Matthew A Tremblay 3; 1 Multiple Sclerosis Comprehensive Care Center, RWJ Barnabas Health, Livingston, NJ, USA. 2 Biogen, Weston, MA, USA. 3 Multiple Sclerosis Comprehensive Care Center, RWJ Barnabas Health, Livingston, NJ, USA. Matthew.Tremblay@rwjbh.org.

Impact of BCG vaccination on the repertoire of human γδ T cell receptors

Xia M, et al.
April 2023
Authors and Affiliates
Mei Xia 1, Azra Blazevic 1, Andrew Fiore-Gartland 2, Daniel F Hoft 1,3; 1 Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, United States. 2 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States. 3 Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO, United States.

Thymic atrophy creates holes in Treg-mediated immuno-regulation via impairment of an antigen-specific clone

Thomas R, et al.
April 2023
immuneAccess
Authors and Affiliates
Rachel Thomas 1, Jiyoung Oh 2, Weikan Wang 1, Dong-Ming Su 3; 1 Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX, USA. 2 Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. 3 Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX, USA.
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