Absence of functional fetal regulatory T cells in humans causes in utero organ-specific autoimmunity

Eric J. Allenspach, MD, PhDa,b Laura S. Finn, MDc,d Mara H. Rendi, MD, PhDd Ahmet Eken, PhDb Akhilesh K. Singh, PhDb Mohamed Oukka, PhDb Sean D. Taylor, PhDb Matthew C. Altman, MDe,f Corinne L. Fligner, MDd,g Hans D. Ochs, MDa,b David J. Rawlings, MDa,b Troy R. Torgerson, MD, PhDa,b aThe Department of Pediatrics, University of Washington School of Medicine, bThe Center for Immunity and Immunotherapies, Seattle Children’s Research Institute, cThe Department of Laboratories, Seattle Children’s Hospital, dThe Department of Pathology, University of Washington School of Medicine, eBenaroya Research Institute, fThe Department of Medicine, University of Washington School of Medicine, and gThe Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington