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Combination Targeted Therapy in Relapsed Diffuse Large B-Cell Lymphoma
Melani C, et al.
New England Journal of Medicine
June 2024
Authors and Affiliates
C. Melani, R. Lakhotia, S. Pittaluga, J.D. Phelan, D.W. Huang, G. Wright, J. Simard, J. Muppidi, C.J. Thomas,
M. Ceribelli, F.A. Tosto, Y. Yang, W. Xu, T. Davies‑Hill, S.D. Pack, C.J. Peer, O. Arisa, E. Mena, L. Lindenberg,
E. Bergvall, C.A. Portell, R.J. Farah, S.T. Lee, A. Pradhan, C. Morrison, A. Tadese, A.M. Juanitez, C. Lu, A. Jacob,
H. Simmons, W.D. Figg, S.M. Steinberg, E.S. Jaffe, M. Roschewski, L.M. Staudt, and W.H. Wilson
Lymphoid Malignancies Branch (C. Melani, R.L., J.D.P., D.W.H., J.S., J.M., Y.Y., W.X., A.P., C. Morrison, A.T., A.M.J., M.R., L.M.S., W.H.W.), the Clinical Pharmacology Program (C.J.P., O.A., W.D.F.), the Molecular Imaging Branch (E.M., L.L., E.B.), and the Biostatistics and Data Management Section (S.M.S.), Center for Cancer Research, the Laboratory of Pathology, Clinical Center (S.P., T.D.-H., S.D.P., E.S.J.), and the Biometric Research Program, Division of Cancer Treatment and Diagnosis (G.W.), National Cancer Institute, the Division of Pre-Clinical Innovation Chemistry Technologies, National Center for Advancing Translational Sciences (C.J.T., M.C., F.A.T.), and the Clinical Center Pharmacy Department (C.L.), National Institutes of Health, Bethesda, and Greenebaum Comprehensive Cancer Center, University of Maryland Medical Center, Baltimore (S.T.L.) — all in Maryland; the Division of Hematology and Oncology, University of Virginia, Charlottesville (C.A.P.); Mario Lemieux Center for Blood Cancers, University of Pittsburgh School of Medicine, Pittsburgh (R.J.F.); and Adaptive Biotechnologies, Seattle (A.J., H.S.)
Linvoseltamab for Treatment of Relapsed/Refractory Multiple Myeloma
Bumma N, et al.
Journal of Clinical Oncology
June 2024
Authors and Affiliates
Naresh Bumma, MD1; Joshua Richter, MD2 ; Sundar Jagannath, MD2 ; Hans C. Lee, MD3 ; James E. Hoffman, MD4;
Attaya Suvannasankha, MD5 ; Jeffrey A. Zonder, MD6 ; Mansi R. Shah, MD7 ; Suzanne Lentzsch, MD, PhD8 ; Rachid Baz, MD9 ;
Joseph J. Maly, MD10; Swathi Namburi, MD11; Matthew J. Pianko, MD12 ; Jing Christine Ye, MD, MS12; Ka Lung Wu, MD, PhD13 ;
Rebecca Silbermann, MD14 ; Chang-Ki Min, MD15; Marie-Christiane Vekemans, MD16; Markus Munder, MD17 ; Ja Min Byun, MD18 ;
Joaqu´ın Mart´ınez-Lopez, MD19 ; Kaniel Cassady, PhD20 ; Michelle DeVeaux, PhD20; Dhruti Chokshi, BS20; Anita Boyapati, PhD20;
Anasuya Hazra, PhD20; George D. Yancopoulos, MD, PhD20; L. Andres Sirulnik, MD, PhD20; Karen Rodriguez Lorenc, MD20; Glenn S. Kroog, MD20 ;
Yariv Houvras, MD, PhD20; and Madhav V. Dhodapkar, MD21
1The Ohio State University Comprehensive Cancer Center, Columbus,
OH
2Icahn School of Medicine at Mount Sinai, New York, NY
3The University of Texas MD Anderson Cancer Centre, Houston, TX
4University of Miami Health System, Miami, FL
5Indiana University Simon Cancer Center and Roudebush VAMC,
Indianapolis, IN
6Karmanos Cancer Institute, Detroit, MI
7Rutgers Cancer Institute of New Jersey, New Brunswick, NJ
8Columbia University Medical Center, New York, NY
9Department of Malignant Hematology, H. Lee Moffitt Cancer Center,
Tampa, FL
10Norton Cancer Institute, Louisville, KY
11Swedish Cancer Institute, Seattle, WA
12Rogel Cancer Center, University of Michigan Medical School, Ann
Arbor, MI
13Ziekenhuis Netwerk Antwerpen Stuivenberg, Antwerp, Belgium
14Knight Cancer Institute, Oregon Health & Science University, Portland,
OR
15Department of Hematology, College of Medicine, Catholic Hematology
Hospital and Leukemia Research Institute, Seoul St Mary’s Hospital,
The Catholic University of Korea, Seoul, South Korea
16Department of Hematology, Cliniques Universitaires Saint-Luc,
Universit´e Catholique de Louvain (UCLouvain), Brussels, Belgium
17Department of Internal Medicine III, University Medical Center Mainz,
Mainz, Germany
18Department of Internal Medicine, Seoul National University College of
Medicine, Seoul National University Hospital, Seoul, Korea
19Hospital 12 de Octubre, i112, School of Medicine Universidad
Complutense, CNIO, Madrid, Spain
20Regeneron Pharmaceuticals, Inc, Tarrytown, NY
21Emory University School of Medicine, Atlanta, GA
Epcoritamab monotherapy in patients with relapsed or refractory follicular lymphoma (EPCORE NHL-1):a phase 2 cohort of a single-arm, multicentre study
Linton K, et al.
Lancet Haematology
June 2024
Bortezomib, thalidomide, and dexamethasone with or without daratumumab and followed by daratumumab maintenance or observation in transplant-eligible newly diagnosed multiple myeloma: long-term follow-up of the CASSIOPEIA randomised controlled phase 3 trial
Moreau P, et al
Lancet Oncology
June 2024
Fixed-Duration Pirtobrutinib plus Venetoclax with or without Rituximab inRelapsed/Refractory CLL: Phase 1b BRUIN Trial
Roeker L, et al.
Blood
June 2024
Authors and Affiliates
Lindsey E. Roeker1, Jennifer A. Woyach2, Chan Y. Cheah3, Catherine C. Coombs4, Nirav N.
Shah5, William G. Wierda6, Manish R. Patel7, Nicole Lamanna8, Donald E. Tsai9, Binoj Nair9,
Chunxiao Wang10, Xiang Zhao9, Dan Liu10, David Radtke10, Sonya Chapman10, Narasimha
Marella9, Samuel C. McNeely9, Jennifer R. Brown11
1Memorial Sloan Kettering Cancer Center, New York, NY, USA
2The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
3Linear Clinical Research, and Sir Charles Gairdner Hospital, and the University of Western
Australia, Perth, Australia
4University of California, Irvine, Orange, CA, USA
5Medical College of Wisconsin, Milwaukee, WI, USA
6MD Anderson Cancer Center, Houston, TX, USA
7Florida Cancer Specialists/Sarah Cannon Research Institute, Sarasota, FL, USA
8Columbia University Medical Center/New York-Presbyterian, New York, NY, USA
9Loxo@Lilly, Indianapolis, IN, USA
10Eli Lilly and Company, Indianapolis, IN, USA
11Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma
Facon T, et al.
New England Journal of Medicine
June 2024
Authors and Affiliates
Thierry Facon, M.D., Meletios‑Athanasios Dimopoulos, M.D., Xavier P. Leleu, M.D.,
Meral Beksac, M.D., Ludek Pour, M.D., Roman Hájek, M.D., Zhuogang Liu, M.D.,
Jiri Minarik, M.D., Philippe Moreau, M.D., Joanna Romejko‑Jarosinska, M.D.,
Ivan Spicka, M.D., Vladimir I. Vorobyev, M.D., Britta Besemer, M.D.,
Tadao Ishida, M.D., Wojciech Janowski, M.D., Sevgi Kalayoglu‑Besisik, M.D.,
Gurdeep Parmar, M.D., Pawel Robak, M.D., Elena Zamagni, M.D.,
Hartmut Goldschmidt, M.D., Thomas G. Martin, M.D., Salomon Manier, M.D.,
Mohamad Mohty, M.D., Corina Oprea, M.D., Marie‑France Brégeault, M.D.,
Sandrine Macé, Ph.D., Christelle Berthou, M.S., David Bregman, M.D.,
Zandra Klippel, M.D., and Robert Z. Orlowski, M.D., for the IMROZ Study Group
Department of Hematology, Centre Hospitalier Universitaire (CHU) de Lille, University of
Lille, Lille (T.F., S. Manier), the French National Academy of Medicine (T.F.), and the Department of Hematology, Hôpital Saint-Antoine,
Sorbonne University and INSERM (M.M.), Paris, Service d’Hématologie et Thérapie Cellulaire, CHU and Centre d’Investigation
Clinique INSERM Unité 1402, Poitiers (X.P.L.), the Department of Hematology, University Hospital Hôtel-Dieu, Nantes (P.M.), and
Sanofi, Research and Development, Vitry-sur-Seine (C.O., M.-F.B., S. Macé, C.B.) — all in France; the Plasma Cell Dyscrasia Unit, Department
of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens (M.-A.D.); the Department of Hematology,
Ankara University, and the Istinye University Ankara Liv Hospital, Ankara (M.B.), and the Department of Internal Medicine, Istanbul
Medical Faculty, Istanbul University, Istanbul (S.K.-B.) — all in Turkey; the Department of Internal Medicine, Hematology, and Oncology,
University Hospital Brno, Brno (L.P.), the Department of Hemato-Oncology, University Hospital Ostrava, and the Faculty of Medicine,
University of Ostrava, Ostrava (R.H.), the Department of Hemato-Oncology, Faculty of Medicine and Dentistry, Palacký University
and University Hospital Olomouc, Olomouc (J.M.), and the Charles University and General Hospital in Prague, Prague (I.S.) — all in
the Czech Republic; Shengjing Hospital of China Medical University, Shenyang, China (Z.L.); the Department of Lymphoid Malignancies,
Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw (J.R.-J.), and the Department of General Hematology,
Copernicus Memorial Hospital, Comprehensive Cancer Center and Traumatology, Łódź (P.R.) — both in Poland; the S.P. Botkin Moscow
City Clinical Hospital, Moscow (V.I.V.); the Department of Hematology, Oncology, Immunology, and Rheumatology, University
Hospital of Tübingen, Tübingen (B.B.), and the Department of Internal Medicine V, University of Heidelberg, Heidelberg (H.G.) — both
in Germany; the Japanese Red Cross Medical Center, Tokyo (T.I.); Calvary Mater Newcastle, Newcastle, NSW (W.J.), and the Illawarra
Cancer Care Centre, Wollongong, NSW (G.P.) — both in Australia; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di
Ematologia “Seràgnoli,” and Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy (E.Z.); the Division
of Hematology–Oncology, University of California, San Francisco, San Francisco (T.G.M.); Sanofi, Patient Safety and Pharmacovigilance,
Bridgewater, NJ (D.B.); Sanofi, Cambridge, MA (Z.K.); and the Department of Lymphoma and Myeloma, University of Texas M.D.
Anderson Cancer Center, Houston (R.Z.O.).
Isatuximab, lenalidomide, dexamethasone and bortezomib in transplant-ineligible multiple myeloma: the randomized phase 3 BENEFIT trial
Leleu X, et al.
Nature Medicine
June 2024
Authors and Affiliates
Xavier Leleu 1,54 , Cyrille Hulin2,54, Jerome Lambert3, Arthur Bobin1, Aurore Perrot 4, Lionel Karlin5, Murielle Roussel6,
Lydia Montes7, Brieuc Cherel8, Thomas Chalopin9, Borhane Slama10, Marie-Lorraine Chretien11, Kamel Laribi12,
Claire Dingremont13, Christophe Roul14, Clara Mariette15, Sophie Rigaudeau16, Claire Calmettes17, Mamoun Dib18,
Mourad Tiab19, Laure Vincent20, Jacques Delaunay21, Alberto Santagostino22, Margaret Macro23, Emmanuelle Bourgeois24,
Frederique Orsini-Piocelle25, Julie Gay26, Benoit Bareau27, Noemie Bigot3, François Vergez28, Pierre Lebreton29,
Reza Tabrizi30, Agathe Waultier-Rascalou31, Laurent Frenzel32, Ronan Le Calloch33, Emilie Chalayer34, Thorsten Braun35,
Florence Lachenal36, Selim Corm37, Celine Kennel38, Rakiba Belkhir39, Jean-Sebastien Bladé40, Bertrand Joly41,
Valentine Richez-Olivier42, Helene Gardeney1, Helene Demarquette43, Daniela Robu-Cretu44, Laurent Garderet45,
Muriel Newinger-Porte46, Amine Kasmi47, Bruno Royer48, Olivier Decaux49, Bertrand Arnulf48, Karim Belhadj50,
Cyrille Touzeau51, Mohamad Mohty52, Salomon Manier53, Philippe Moreau51, Hervé Avet-Loiseau28, Jill Corre 28 &
Thierry Facon53
1Hematology, CIC 1082, U1313, CHU, University, Poitiers, France. 2CHU, Bordeaux, France. 3SBIM, Saint-Louis Hospital, Paris, France. 4University Hospital,
iUCT Oncopole, Toulouse, France. 5Hôpital Lyon Sud, Pierre-Benite, France. 6Hematology, CHU, Limoges, France. 7Hematology, CHU, Amiens, France.
8CH Bretagne Atlantique, Vannes, France. 9Hematology, CHU, Tours, France. 10Hospital center, Avignon, France. 11Hematology, University Hospital,
Inserm U1231, University of Burgundy Franche-Comté, Dijon, France. 12Hematology, CH, Le Mans, France. 13Internal Medicine, Tarbes-Lourdes Hospital,
Tarbes, France. 14CH La Rochelle, La Rochelle, France. 15Hematology, CHU, Grenoble, France. 16Hématologie – Le Chesnay, CH Versaille, Paris, France.
17CH, Périgueux, France. 18University Hospital, Angers, France. 19Hematology, CH Departemental de La Roche-sur-Yon, La Roche-sur-Yon, France.
20CHU, Montpellier, France. 21Hôpital privé du confluent 2, Nantes, France. 22Hematology, CH, Troyes, France. 23Hematology, IHBN – CHU, Caen,
France. 24GHICL, Lille, France. 25Hématologie, CH, Annecy Genevois, France. 26Hematology, CH de la côte basque, Bayonne, France. 27Hematology,
Les Hôpitaux Privés Rennais Cesson Sévigné - Vivalto Santé, Cesson Sévigné, France. 28Unit for Genomics in Myeloma, iUCT Oncopole, Toulouse,
France. 29Hematology, CH, Le Havre, France. 30Hematology, CHI de Mont De Marsan, Mont-de-Marsan, France. 31Hematology, CHU, Nîmes, France.
32Hematology, Necker Hospital, Paris, France. 33Hematology, CH de Cornouaille, Quimper Concarneau, Concarneau, France. 34Hematology, CHU,
Saint-Etienne, France. 35Hematology, Avicenne hospital APHP, Bobigny, France. 36CH Pierre Oudot, Bourgoin-Jallieu, France. 37Medipole de Savoie,
Challes les Eaux, France. 38CH William Morey, Chalon sur Saône, France. 39Rheumatology, Hopital Bicetre, AP-HP, Universite Paris Saclay, Paris, France.
40Onco-Hematology Department, HIA Sainte Anne, Toulon, France. 41CH Sud Francilien, Corbeil Essonnes, France. 42CHU de Nice, Nice, France.
43Hematology, CH, Dunkerque, France. 44Hematology, CH, Lens, France. 45Hopital Pitié Salpetriere, hématologie APHP, Paris, France. 46Hôpital Emile
Muller, Mulhouse, France. 47DRC, CHU, Poitiers, France. 48Hôpital Saint-Louis, Paris, France. 49Hematology, UMR U1236, University Hospital, Rennes,
France. 50C.H.U. Henri Mondor, Créteil, France. 51Hématologie, CHU Hotel Dieu Université, Nantes, France. 52Hematology, Sorbonne University,
Saint-Antoine Hôpital (AP-HP), UMRs 938, Paris, France. 53Hematology, University Hospital Inserm U-S1277 and CNRS UMR9020, Lille, France.
54These authors contributed equally: Xavier Leleu, Cyrille Hulin.
Belantamab Mafodotin, Pomalidomide,and Dexamethasone in Multiple Myeloma
Dimopoulos M, et al.
New England Journal of Medicine
June 2024
Authors and Affiliates
Meletios Athanasios Dimopoulos, M.D., Meral Beksac, M.D., Ludek Pour, M.D.,
Sosana Delimpasi, M.D., Vladimir Vorobyev, M.D., Hang Quach, M.D.,
Ivan Spicka, C.Sc., Jakub Radocha, M.D., Ph.D., Pawel Robak, M.D., Ph.D.,
Kihyun Kim, M.D., Michele Cavo, M.D., Kazuhito Suzuki, M.D., Ph.D.,
Kristin Morris, Pharm.D., Farrah Pompilus, Ph.D., Amy Phillips‑Jones, M.Sc.,
Xiaoou L. Zhou, M.D., Ph.D., Giulia Fulci, Ph.D., Neal Sule, M.B., B.S., M.D.,
Brandon E. Kremer, M.D., Ph.D., Joanna Opalinska, M.D., Ph.D.,
María‑Victoria Mateos, M.D., Ph.D., and Suzanne Trudel, M.D.,
for the DREAMM-8 Investigators
Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University
of Athens (M.A.D.), and General Hospital Evangelismos (S.D.) — both in Athens; the Department of Hematology, Ankara Liv
Hospital, Istinye University, Ankara, Turkey (M.B.); the Department of Internal Medicine, Hematology, and Oncology, University Hospital
Brno, Brno (L.P.), the First Faculty of Medicine, Charles University, and General Hospital, Prague (I.S.), and the Fourth Department
of Internal Medicine–Hematology, University Hospital Hradec Králové, and Faculty of Medicine in Hradec Králové, Charles University,
Hradec Králové (J.R.) — all in the Czech Republic; Leningrad Regional Clinical Hospital, Saint Petersburg, Russia (V.V.); the University
of Melbourne, St. Vincent’s Hospital, Melbourne, VIC, Australia (H.Q.); Medical University of Lodz, Łódź, Poland (P.R.); Sungkyunkwan
University and Samsung Medical Center, Seoul, South Korea (K.K.); IRCCS Azienda Ospedaliero–Universitaria di Bologna,
Seràgnoli Institute of Hematology, and Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy (M.C.); the
Division of Clinical Oncology–Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo (K.S.); GSK,
Durham, NC (K.M.); GSK, Philadelphia (F.P.), and GSK, Collegeville (N.S., B.E.K., J.O.) — both in Pennsylvania; GSK, Stevenage,
United Kingdom (A.P.-J.); GSK, Waltham, MA (X.L.Z., G.F.); the Hematology Department, Cancer Research Center–Instituto de Investigación
Biomédica de Salamanca, University Hospital of Salamanca, Salamanca, Spain (M.-V.M.); and the Department of Medical
Oncology and Hematology, Princess Margaret Cancer Center, Toronto (S.T.)
Belantamab Mafodotin, Bortezomib, and Dexamethasone for Multiple Myeloma
Hungria V, et al.
New England Journal of Medicine
June 2024
Authors and Affiliates
V. Hungria, P. Robak, M. Hus, V. Zherebtsova, C. Ward, P.J. Ho,
A.C. Ribas de Almeida, R. Hajek, K. Kim, S. Grosicki, H. Sia, A. Bryant,
M. Pitombeira de Lacerda, G. Aparecida Martinez, A.M. Sureda Balarí, I. Sandhu,
C. Cerchione, P. Ganly, M. Dimopoulos, C. Fu, M. Garg, A.-O. Abdallah, A. Oriol,
M.E. Gatt, M. Cavo, R. Rifkin, T. Fujisaki, M. Mielnik, N. Pirooz, A. McKeown,
S. McNamara, X. Zhou, M. Nichols, E. Lewis, R. Rogers, H. Baig, L. Eccersley,
S. Roy‑Ghanta, J. Opalinska, and M.-V. Mateos, for the DREAMM-7 Investigators
Clinica São Germano (V.H.) and Hospital das Clínicas and Instituto do Câncer do Estado de
São Paulo, Universidade de São Paulo (G.A.M.), São Paulo, Centro de Pesquisa e Ensino em Saúde de Santa Catarin, Florianópolis
(A.C.R.A.), and Universidade da Região de Joinville and Centro de Hematologia e Oncologia, Joinville (M.P.L.) — all in Brazil; Medical
University of Lodz, Lodz (P.R.), Medical University of Lublin, Lublin (M.H., M.M.), and the Medical University of Silesia, Katowice (S.G.)
— all in Poland; Gorodskaya Klinicheskaya Bol’nitsa Imeni Saint Petersburg Botkina, Moscow (V.Z.); the Royal North Shore Hospital
(C.W.) and Liverpool Hospital (A.B.), Sydney, Royal Prince Alfred Hospital and University of Sydney, Camperdown, NSW (P.J.H.), and
Pindara Private Hospital, Gold Coast, QLD (H.S.) — all in Australia; the Department of Hematooncology, University Hospital Ostrava,
and Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic (R.H.); Sungkyunkwan University and Samsung Medical Center,
Seoul, South Korea (K.K.); Institut Català d’Oncologia–L’Hospitalet de Llobregat–Barcelona, Barcelona (A.M.S.B.), Institut Català
d’Oncologia and Josep Carreras Research Institute, Hospital Germans Trias i Pujol, Badalona (A.O.), and Hospital Universitario de
Salamanca, Instituto de Investigación Biomédica de Salamanca, Centro de Investigación del Cáncer, Ciberonc, Salamanca (M.-V.M.)
— all in Spain; Cross Cancer Institute, Edmonton (I.S.), and GSK, Mississauga (H.B.) — both in Canada; the Hematology Unit, Istituto
Romagnolo per lo Studio dei Tumori “Dino Amadori,” IRST IRCCS, Meldola (C.C.), and IRCCS Azienda Ospedaliero–Universitaria
di Bologna, Istituto di Ematologia “Seràgnoli,” Bologna (M.C.) — both in Italy; Christchurch Hospital, Christchurch, New Zealand
(P.G.); National and Kapodistrian University of Athens, Athens (M.D.); the First Affiliated Hospital of Soochow University, Suzhou,
China (C.F.); University Hospitals of Leicester NHS Trust, Leicester (M.G.), GSK, Stevenage (A.M., S.M.), and GSK, London (L.E.) — all
in the United Kingdom; University of Kansas Cancer Center, Fairway (A.-O.A.); the Department of Hematology, Hadassah Medical
Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel (M.E.G.); Rocky Mountain Cancer Centers–Denver–Midtown,
Denver (R. Rifkin); Matsuyama Red Cross Hospital, Matsuyama, Japan (T.F.); GSK, Upper Providence, PA (N.P., X.Z., R. Rogers,
S.R.-G., J.O.); and GSK, Durham (M.N.), and GSK, Research Triangle Park (E.L.) — both in North Carolina
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