ASH 2023: MRD Highlights in BioPharma Drug Development

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Identifying immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donors

May DH, et al.
bioRxiv
March 2024
Authors and Affiliates
Damon H. May 1, Steven Woodhouse 1, H. Jabran Zahid 2, Rebecca Elyanow 1, Kathryn Doroschak 1, Matthew T. Noakes 1, Ruth Taniguchi 1, Zheng Yang 1, John R. Grino 1, Rachel Byron 1, Jamie Oaks 1, Anna Sherwood 1, Julia Greissl 2, Haiyin Chen-Harris 1, Bryan Howie 1, Harlan S. Robins 1 1: Adaptive Biotechnologies - 1165 Eastlake Ave E, Seattle, WA 98109 2: Microsoft Research - 14820 NE 36th St, Redmond, WA 98052

Complete loss of TP53 and RB1 is associated with complex genome and low immune infiltrate in pleomorphic rhabdomyosarcoma

Beird H et al.
HGG Advances
February 2024
Authors and Affiliates
Hannah C. Beird; Chia-Chin Wu; Michael Nakazawa; Davis Ingram; Joseph R. Daniele; Rossana Lazcano; Latasha Little; Christopher Davies; Najat C. Daw; Khalida Wani; Wei-Lien Wang; Xingzhi Song; Curtis Gumbs; Jianhua Zhang; Brian Rubin; Anthony Conley; Adrienne M. Flanagan; Alexander J. Lazar and P. Andrew Futreal.

Antigen-presenting B cells promote TCF-1+ PD1-stem-like CD8+ T-cell proliferation in glioblastoma

Hou D et al.
Frontiers in Immunology
February 2024
Authors and Affiliates
David Hou; Hanxiao Wan; Joshua L. Katz; Si Wang; Brandyn A. Castro; Gustavo I. Vazquez-Cervantes; Victor A. Arrieta; Silpol Dhiantravan; Hinda Najem; Aida Rashidi; Tzu-yi Chia; Tarlan Arjmandi; Jimena Collado; Leah Billingham; Aurora Lopez-Rosas; Yu Han; Adam M. Sonabend; Amy B. Heimberger; Peng Zhang; Jason Miska and Catalina Lee-Chang.

Single-cell analysis of immune recognition in chronic myeloid leukemia patients following tyrosine kinase inhibitor discontinuation

Huuhtanen, J et al.
Nature
February 2024
Authors and Affiliates
Jani Huuhtanen; Shady Adnan-Awad; Jason Theodoropoulos; Sofia Forstén; Rebecca Warfvinge; Olli Dufva; Jonas Bouhlal; Parashar Dhapola; Hanna Duàn; Essi Laajala; Tiina Kasanen; Jay Klievink; Mette Ilander; Taina Jaatinen; Ulla Olsson-Strömberg; Henrik Hjorth-Hansen; Andreas Burchert; Göran Karlsson; Anna Kreutzman; Harri Lähdesmäki and Satu Mustjoki.

SARS-CoV-2 vaccination in the first year after hematopoietic cell transplant or chimeric antigen receptor T cell therapy: A prospective, multicenter, observational study (BMTCTN 2101)

Hill JA, et al.
January 2024
Authors and Affiliates
Joshua A. Hill, MD; Michael J. Martens, PhD; Jo-Anne H. Young, MD; Kavita Bhavsar, MSc; Jianqun Kou, MS; Min Chen, MS; Lik Wee Lee, PhD; Aliyah Baluch, MD; Madhav V. Dhodapkar, MBBS; Ryotaro Nakamura, MD; Kristin Peyton, BS; Dianna S. Howard, MD; Uroosa Ibrahim, MD; Zainab Shahid, MD; Paul Armistead, MD; Peter Westervelt, MD; John McCarty, MD; Joseph McGuirk, DO; Mehdi Hamadani, MD; Susan DeWolf, MD; Kinga Hosszu, PhD; Elad Sharon, MD, MPH; Ashley Spahn, BS; Amir A. Toor, MD; Stephanie Waldvogel, BS; Lee M. Greenberger, PhD; Jeffery J. Auletta, MD; Mary M. Horowitz, MD*; Marcie L. Riches, MD; Miguel-Angel Perales, MD

Locus folding mechanisms determine modes of antigen receptor gene assembly

Allyn BM, et al.
Journal of Experimental Medicine
January 2024
Authors and Affiliates
Brittney M Allyn 1,2, Katharina E Hayer 2,3,4, Clement Oyeniran 5, Vincent Nganga 5, Kyutae Lee 2, Bikash Mishra 5, Ahmet Sacan 3, Eugene M Oltz 5, Craig H Bassing 1,2; 1 Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA, USA. 2 Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. 3 Biomedical Engineering Doctoral Degree Program, School of Biomedical Engineering, Science and Health Systems, Drexel University , Philadelphia, PA, USA. 4 Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, PA, USA. 5 Department of Microbial Infection and Immunity, Ohio State College of Medicine, Ohio State University, Columbus, OH, USA.

Perturbations of the T-cell receptor repertoire in response to SARS-CoV-2 in immunocompetent and immunocompromised individuals

Delmonte OM, et al.
Journal of Allergy and Clinical Immunology
January 2024
Authors and Affiliates
Ottavia M Delmonte 1, Cihan Oguz 2, Kerry Dobbs 3, Katherine Myint-Hpu 3, Boaz Palterer 3, Michael S Abers 3, Deborah Draper 3, Meng Truong 3, Ian M Kaplan 4, Rachel M Gittelman 4, Yu Zhang 3, Lindsey B Rosen 3, Andrew L Snow 5, Clifton L Dalgard 6, Peter D Burbelo 7, Luisa Imberti 8, Alessandra Sottini 8, Eugenia Quiros-Roldan 9, Francesco Castelli 9, Camillo Rossi 10, Duilio Brugnoni 11, Andrea Biondi 12, Laura Rachele Bettini 12, Mariella D'Angio' 12, Paolo Bonfanti 13, Megan V Anderson 14, Annalisa Saracino 15, Maria Chironna 16, Mariantonietta Di Stefano 17, Jose Ramon Fiore 17, Teresa Santantonio 17, Riccardo Castagnoli 18, Gian Luigi Marseglia 18, Mary Magliocco 19, Marita Bosticardo 3, Francesca Pala 3, Elana Shaw 3, Helen Matthews 19, Sarah E Weber 19, Sandhya Xirasagar 20, Jason Barnett 20, Andrew J Oler 20, Dimana Dimitrova 21, Jenna R E Bergerson 3, David H McDermott 22, V Koneti Rao 3, Philip M Murphy 22, Steven M Holland 3, Andrea Lisco 14, Helen C Su 3, Michail S Lionakis 3, Jeffrey I Cohen 23, Alexandra F Freeman 3, Thomas M Snyder 4, Justin Lack 2, Luigi D Notarangelo 24; 1 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: ottavia.delmonte@nih.gov. 2 Integrated Data Sciences Section, Research Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 3 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 4 Adaptive Biotechnologies, Seattle, WA 98109, USA. 5 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD 20892, USA. 6 Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA; The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD 20815, USA. 7 Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. 8 Section of Microbiology, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy. 9 Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy. 10 Direzione Sanitaria, ASST Spedali Civili di Brescia, Italy. 11 Laboratorio Analisi Chimico-Cliniche, ASST Spedali Civili, Brescia, Italy. 12 Pediatric Department and Centro Tettamanti-European Reference Network on Paediatric Cancer, European Reference Network on Haematological Diseases, and European Reference Network on Hereditary Metabolic Disorders-University of Milano-Bicocca-Fondazione MBBM, Monza, Italy. 13 Department of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy. 14 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 15 Clinic of Infectious Diseases, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, University of Bari, Bari, Italy. 16 Hygiene Section, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy. 17 Department of Medical and Surgical Sciences, Section of Infectious Diseases, University of Foggia, Foggia, Italy. 18 Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 19 Molecular Development of the Immune System Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD 20892, USA. 20 Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 21 Center for Immuno-Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. 22 Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. 23 Laboratory of Infectious Diseases, National Institute of Allergy and Infectious diseases, National Institutes of Health, Bethesda, MD 20892, USA. 24 Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: luigi.notarangelo2@nih.gov.
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