Tumor- and neoantigen-reactive T-cell receptors can be identified based on their frequency in fresh tumor

Anna Pasetto1 , Alena Gros1 , Paul F Robbins1 , Drew C Deniger1 , Todd D Prickett1 , Rodrigo Matus-Nicodemos2,3 , Daniel C Douek3 , Bryan Howie4 , Harlan Robins4,5 , Maria R Parkhurst1 , Jared Gartner1 , Katarzyna Trebska-McGowan1 , Jessica S Crystal1 , Steven A Rosenberg1 * 1Surgery Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA, 2Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA, 3Human Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA, 4Adaptive Biotechnologies, Seattle, WA 98102, USA, 5Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA