Prevalent and diverse intratumoral oncoprotein-specific CD8+ T cells within polyoma virus-driven Merkel cell carcinomas

Lichen Jing 1, Mariliis Ott 1, Candice D. Church 2, Rima M. Kulikauskas 2, Dafina Ibrani 2, Jayasri G. Iyer 2, Olga K. Afanasiev 2, Aric Colunga 2, Maclean M. Cook 2, Hong Xie 6, Alexander L. Greninger 6, Kelly G. Paulson 8,3, Aude G. Chapuis 8,3, Shailender Bhatia 8,3, Paul Nghiem 2,3, David M. Koelle 1,4,5,6,7,9 1 Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA 2 Division of Dermatology, Department of Medicine, University of Washington, Seattle, WA, USA 3 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA 4 Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA 5 Department of Global Health, University of Washington, Seattle, WA, USA 6 Department of Laboratory Medicine, University of Washington, Seattle, WA, USA 7 Benaroya Research Institute, Seattle, WA, USA 8 Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA, USA 9 Correspondence at: 750 Republican Street, Room E651, Seattle, WA, 98109, USA; tel 206 616 1940; fax 206 616 4898, email dkoelle@medicine.washington.edu