Compartmental analysis of T cell clonal dynamics as a function of pathologic response to neoadjuvant PD-1 blockade in resectable non-small cell lung cancer
Zhang et al.
Clinical Cancer Research
November 2019
Authors and Affiliates
Jiajia Zhang1,2, Zhicheng Ji3
, Justina X. Caushi1,2, Margueritta El Asmar1,2, Valsamo Anagnostou1,2,
Tricia R. Cottrell1,2,4, Hok Yee Chan1,2, Prerna Suri1,2, Haidan Guo1,2, Taha Merghoub5
, Jamie E. Chaft5
,
Joshua E. Reuss1,2, Ada J. Tam1,2, Richard L. Blosser1,2, Mohsen Abu-Akeel5
, John-William Sidhom1,2,
Ni Zhao3
, Jinny S. Ha2,6, David R. Jones7
, Kristen A. Marrone1,2, Jarushka Naidoo1,2, Edward Gabrielson1,2,
Janis M. Taube1,2,4, Victor E. Velculescu1,2, Julie R. Brahmer1,2, Franck Housseau1,2, Matthew D. Hellmann5
,
Patrick M. Forde1,2, Drew M. Pardoll1,2, Hongkai Ji3
, and Kellie N. Smith1,2; 1
The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins
University School of Medicine, Baltimore, Maryland. 2
The Sidney Kimmel
Comprehensive Cancer Center, Johns Hopkins University School of Medicine,
Baltimore, Maryland. 3
Department of Biostatistics, Johns Hopkins Bloomberg
School of Public Health, Johns Hopkins University, Baltimore, Maryland. 4
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore,
Maryland. 5
Thoracic Oncology Service, Department of Medicine, Memorial Sloan
Kettering Cancer Center and Weill Cornell Medical Center, New York, New York.
6
Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University
School of Medicine, Baltimore, Maryland. 7
Thoracic Service, Department of
Surgery, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical
Center, New York, New York