Browse our 1,000+ Publications​

Latest Publications

Overcoming primary and acquired resistance to anti-PD-L1 therapy by induction and activation of tumor-residing cDC1s

Oba T., et al.
October 2020
Authors and Affiliates
Takaaki Oba 1,8, Mark D. Long 2,8, Tibor Keler3, Henry C. Marsh 3, Hans Minderman 4, Scott I. Abrams 5,9, Song Liu2,9 & Fumito Ito 1,5,6,7; 1 Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 2 Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 3 Celldex Therapeutics, Inc., Hampton, NJ, USA. 4 Flow & Image Cytometry Shared Resource, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 5 Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 6 Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 7 Department of Surgery, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, NY, USA. 8 These authors contributed equally: Takaaki Oba, Mark D. Long. 9 These authors jointly supervised: Scott I. Abrams, Song Liu. email: fumito.ito@roswellpark.org

The Immune Phenotype of Isolated Lymphoid Structures in Non-Tumorous Colon Mucosa Encrypts the Information on Pathobiology of Metastatic Colorectal Cancer

Mungenast F, et al.
October 2020
Authors and Affiliates
Felicitas Mungenast 1,†, Anastasia Meshcheryakova 1,†,*, Andrea Beer 2, Martina Salzmann 1, Dietmar Tamandl 3, Thomas Gruenberger 4,‡, Peter Pietschmann 1, Oskar Koperek 2,§, Peter Birner 2, Ilan Kirsch 5, Harlan Robins 5, Martina Mittlboeck 6, Markus Jaritz 7, Michael Bergmann 8, Philip Zimmermann 9 and Diana Mechtcheriakova 1,*; 1 Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna 1090, Austria; felicitas.mungenast@meduniwien.ac.at (F.M.); martina.salzmann@meduniwien.ac.at (M.S.); peter.pietschmann@meduniwien.ac.at (P.P.) 2 Department of Pathology, Medical University of Vienna, Vienna 1090, Austria; andrea.beer@meduniwien.ac.at (A.B.); Koperek@labor-kaserer.at (O.K.); peter.birner@meduniwien.ac.at (P.B.) 3 Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna 1090, Austria; dietmar.tamandl@meduniwien.ac.at 4 Department of Surgery, Kaiser Franz Josef Hospital, Vienna 1100, Austria; thomas.gruenberger@gesundheitsverbund.at 5 Adaptive Biotechnologies Corporation, Seattle, WA 98102, USA; lkirsch@adaptivebiotech.com (I.K.); hrobins@adaptivebiotech.com (H.R.) 6 Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna 1090, Austria; martina.mittlboeck@meduniwien.ac.at 7 Research Institute of Molecular Pathology, Vienna Biocenter, Vienna 1030, Austria; Markus.Jaritz@imp.ac.at 8 Department of Surgery, Medical University of Vienna, Vienna 1090, Austria; michael.bergmann@meduniwien.ac.at 9 Nebion AG, Zürich, 8048, Switzerland; phz@nebion.com * Correspondence: diana.mechtcheriakova@meduniwien.ac.at (D.M.); anastasia.meshcheryakova@meduniwien.ac.at (A.M.) † These authors contributed equally to this work. ‡ Current affiliation: Department of Surgery I, Rudolf Foundation Clinic, Vienna 1030, Austria. § Current affiliation: Clinical Pathology Laboratory Kaserer, Koperek and Beer, Vienna 1030, Austria.

Long-term Sculpting of the B-cell Repertoire following Cancer Immunotherapy in Patients Treated with Sipuleucel-T

Zhang L., et al.
Cancer Immunology Research
October 2020
immuneAccess
Authors and Affiliates
Li Zhang 1,2, Harini Kandadi 3, Hai Yang 2, Jason Cham 1 4, Tao He 5, David Y Oh 1, Nadeem A Sheikh 3, Lawrence Fong 6; 1 Department of Medicine, University of California San Francisco, San Francisco, California. 2 Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, California. 3 Dendreon Pharmaceuticals LLC, Seattle, Washington. 4 Department of Internal Medicine, Scripps Green Hospital, La Jolla, California. 5 Department of Mathematics, San Francisco State University, San Francisco, California. 6 Department of Medicine, University of California San Francisco, San Francisco, California. lawrence.fong@ucsf.edu.

Antimalarial antibody repertoire defined by plasma IG proteomics and single B cell IG sequencing

Coelho CH., et al.
JCI Insight
October 2020
Authors and Affiliates
Camila H Coelho 1, Steven T Nadakal 1, Patricia A Gonzales Hurtado 1, Robert Morrison 1, Jacob D Galson 2, Jillian Neal 1, Yimin Wu 3, C Richter King 3, Virginia Price 3, Kazutoyo Miura 4, Sharon Wong-Madden 1, Justin Ya Dortichamou 1, David L Narum 1, Nicholas J MacDonald 1, Maryonne Snow-Smith 1, Marissa Vignali 5, Justin J Taylor 6, Marie-Paule Lefranc 7, Johannes Trück 8, Carole A Long 4, Issaka Sagara 9, Michal Fried 1, Patrick E Duffy 1; 1 Laboratory for Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, NIH, Rockville, United States of America. 2 Department of Pediatrics, University Children's Hospital Zürich, Zürich, Switzerland. 3 PATH's Malaria Vaccine Initiative, Washington DC, United States of America. 4 Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, United States of America. 5 Adaptive Biotechnologies, Inc., Seattle, United States of America. 6 Fred Hutchinson Cancer Research Center, University of Washington, Seattle, United States of America. 7 Institut de Génétique Humaine, Université Montpellier 2, Montpellier, France. 8 Department of Immunology, University Children's Hospital Zürich, Zürich, Switzerland. 9 Malaria Research and Training Center, University of Bamako, Bamako, Mali.

Circulating α4β7+ Memory T Cells in Pediatric IBD Patients Express a Polyclonal T Cell Receptor Repertoire

Gamliel A., et al.
Clinical and Experimental Gastroenterology
October 2020
Authors and Affiliates
Adir Gamliel 1,2, Lael Werner 1,2, Marina Pinsker 1,3, Naomi Salamon 1, Batia Weiss 1,2, Dror S Shouval 1,2; 1 Pediatric Gastroenterology Unit, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Ramat Gan, Israel 2 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel 3 Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan, Israel

Adherent cell depletion promotes the expansion of renal cell carcinoma infiltrating T cells with optimal characteristics for adoptive transfer

Braun MW., et al.
Journal for ImmunoTherapy of Cancer
October 2020
Authors and Affiliates
Mitchell W Braun 1, Haitham Abdelhakim 2, Meizhang Li 1, Stephen Hyter 1, Ziyan Pessetto 1, Devin C Koestler 3, Harsh B Pathak 1,4, Neil Dunavin 5,6, Andrew K Godwin 7,4; 1 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA. 2 Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA. 3 Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA. 4 The University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City, Kansas, USA. 5 UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA. 6 Division on Hematology and BMT, UCSF, San Francisco, California, USA. 7 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA agodwin@kumc.edu.

T cell repertoire analysis suggest a prominent bystander response in human cardiac allograft vasculopathy

Habal MV., et al.
American Journal of Transplantation
October 2020
Authors and Affiliates
Marlena V Habal 1,2, April M I Miller 1,3, Samhita Rao 1, Sijie Lin 1,4, Aleksandar Obradovic 1, Mohsen Khosravi-Maharlooei 1, Sarah See 1, Poulomi Roy 1, Shihab Ronzon 1, Siu-Hong Ho 1,5, Charles Marboe 6, Yoshifumi Naka 7, Koji Takeda 7, Susan Restaino 2, Arnold Han 1, Donna Mancini 8, Michael Givertz 9, Joren C Madsen 10,11, Megan Sykes 1, Linda Addonizio 12, Maryjane Farr 2, Emmanuel Zorn 1; 1 Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA. 2 Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York, NY, USA. 3 Case Western Reserve University School of Medicine, NY, USA. 4 Stanford University, Department of Genetics, NY, USA. 5 Cytek Biosciences, NY, USA. 6 Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. 7 Department of Surgery, Division of Cardiothoracic Surgery, Columbia University Irving Medical Center, New York, NY, USA. 8 Department of Medicine, Mount Sinai Hospital, Icahn School of Medicine, New York, NY, USA. 9 Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 10 Center for Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 11 Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 12 Department of Pediatrics, Division of Pediatric Cardiology, Columbia University Irving Medical Center, New York, NY, USA.

Cutaneous T-cell lymphomas with pathogenic somatic mutations and absence of detectable clonal T-cell receptor gene rearrangement: two case reports

Rojansky R., et al.
Diagnostic Pathology
October 2020
Authors and Affiliates
Rebecca Rojansky 1, Sebastian Fernandez-Pol 1, Erica Wang 2, Kerri E Rieger 1,2, Roberto A Novoa 1,2, James L Zehnder 1,3, Christian A Kunder 1, Youn H Kim 2,4, Michael S Khodadoust 2,4, Ryanne A Brown 5,6,7; 1 Department of Pathology, Stanford Medicine, Stanford, CA, 94305, USA. 2 Department of Dermatology, Stanford Medicine, Stanford, CA, 94305, USA. 3 Division of Hematology, Department of Medicine, Stanford Medicine, Stanford, CA, 94305, USA. 4 Division of Oncology, Department of Medicine, Stanford Medicine, Stanford, CA, 94305, USA. 5 Department of Pathology, Stanford Medicine, Stanford, CA, 94305, USA. rbrown85@stanford.edu. 6 Department of Dermatology, Stanford Medicine, Stanford, CA, 94305, USA. rbrown85@stanford.edu. 7 Department of Pathology, Veterans Affairs Palo Alto Health Care System, 3375 Hillview Ave, Room 1821, Palo Alto, CA, 94304-1204, USA. rbrown85@stanford.edu.

CDK4/6 inhibition enhances antitumor efficacy of chemotherapy and immune checkpoint inhibitor combinations in preclinical models and enhances T-cell activation in patients with SCLC receiving chemotherapy

Lai AY., et al.
Journal for ImmunoTherapy of Cancer
October 2020
Authors and Affiliates
Anne Y Lai 1, Jessica A Sorrentino 2, Konstantin H Dragnev 3, Jared M Weiss 4, Taofeek K Owonikoko 5, Julie A Rytlewski 6, Jill Hood 6, Zhao Yang 1, Rajesh K Malik 1, Jay C Strum 1, Patrick J Roberts 1; 1 Research and Development, G1 Therapeutics, Inc, Research Triangle Park, North Carolina, USA. 2 Research and Development, G1 Therapeutics, Inc, Research Triangle Park, North Carolina, USA jsorrentino@g1therapeutics.com. 3 Department of Hematology and Oncology, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA. 4 Division of Hematology and Oncology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, USA. 5 Department of Hematology and Medical Oncology, Emory University Winship Cancer Institute, Atlanta, Georgia, USA. 6 Life Sciences Research, Adaptive Biotechnologies Corp, Seattle, Washington, USA.

mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

Cafri G., et al.
JCI
Journal of Clinical Investigation
October 2020
Authors and Affiliates
Gal Cafri 1 2, Jared J Gartner 1, Tal Zaks 3, Kristen Hopson 3, Noam Levin 1, Biman C Paria 1, Maria R Parkhurst 1, Rami Yossef 1, Frank J Lowery 1, Mohammad S Jafferji 1, Todd D Prickett 1, Stephanie L Goff 1, Christine T McGowan 1, Samantha Seitter 1, Mackenzie L Shindorf 1, Anup Parikh 1, Praveen D Chatani 1, Paul F Robbins 1, Steven A Rosenberg 1; 1 Surgery Branch, National Cancer Institute (NCI), NIH, Bethesda, Maryland, USA. 2 Sheba Medical Center, Ramat Gan, Israel. 3 Moderna Inc., Cambridge, Massachusetts, USA.
Previous Next