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Lymphocytic infiltration in stage II microsatellite stable colorectal tumors: A retrospective prognosis biomarker analysis
Authors and Affiliates
Rebeca Sanz-Pamplona 1,2,3, Marilena Melas 4, Asaf Maoz 5, Stephanie L Schmit 6, Hedy Rennert 7, Flavio Lejbkowicz 7, Joel K Greenson 8, Xavier Sanjuan 9, Maria Lopez-Zambrano 9, M Henar Alonso 1,2,3 10, Chenxu Qu 11, Kevin J McDonnell 11, Gregory E Idos 11, Marissa Vignali 12, Ryan Emerson 12, Paul Fields 12, Elisabet Guinó 1,2,3, Cristina Santos 1,2,13, Ramon Salazar 1,2,13, Harlan S Robins 12,14, Gad Rennert 7, Stephen B Gruber 11, Victor Moreno 1,2,3,10;
1 Catalan Institute of Oncology (ICO), Hospitalet de Llobregat, Barcelona, Spain.
2 ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain.
3 Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Spain.
4 Nationwide Children's Hospital, Columbus, Ohio, United States of America.
5 Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America.
6 H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America.
7 Carmel Medical Center, and Technion, Haifa, Israel.
8 University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
9 University Hospital Bellvitge (HUB-IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
10 Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
11 City of Hope National Medical Center, Duarte, California, United States of America.
12 Adaptive Biotechnologies, Seattle, Washington, United States of America.
13 Consortium for Biomedical Research in Oncology (CIBERONC), Spain.
14 Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Serial Assessment of Circulating T lymphocyte Phenotype and Receptor Repertoire During Treatment of Non-Muscle Invasive Bladder Cancer with Adoptive T Cell Immunotherapy
Wang X., et al.
September 2020
Authors and Affiliates
Xiaoli Wang 1, Guoliang Qiao 1, Ni Jiang 1, Michael A Morse 2, Xinna Zhou 1, Shuo Wang 1, Jiangping Wu 1, Yuguang Song 1, Yanjie Zhao 1, Lei Zhou 1, Yanhua Yuan 1, Amy Hobeika 2, Jun Ren 1, Herbert Kim Lyerly 1;
1 Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, China
2 Duke University Medical Center, Durham, NC, USA
Human thymic T cell repertoire is imprinted with strong convergence to shared sequences
Authors and Affiliates
Nelli Heikkilä a,*, Reetta Vanhanen b, Dawit A. Yohannes c, Iivari Kleino d, Ilkka P. Mattila e, Jari Saramäki f, T. Petteri Arstila g;
a Research Programs Unit, Translational Immunology and Medicum, Department of Bacteriology and Immunology, University of Helsinki. Haartmaninkatu 3, 00290
Helsinki, Finland
b Research Programs Unit, Translational Immunology and Medicum, Department of Bacteriology and Immunology, University of Helsinki. Haartmaninkatu 3, 00290
Helsinki, Finland
c Research Programs Unit, Translational Immunology and Medicum, Department of Medical and Clinical Genetics, University of Helsinki. Haartmaninkatu 8, 00290
Helsinki, Finland
d Research Programs Unit, Translational Immunology, University of Helsinki. Haartmaninkatu 3, 00290 Helsinki, Finland
e Department of Pediatric Cardiac and Transplantation Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital. Stenbäckinkatu 9, 00290
Helsinki, Finland
f Department of Computer Science, Aalto University. Konemiehentie 2, 02150 Espoo, Finland
g Research Programs Unit, Translational Immunology and Medicum, Department of Bacteriology and Immunology, University of Helsinki. Haartmaninkatu 3, 00290
Helsinki, Finland
Exhaustion of tumour-infiltrating T-cell receptor repertoirediversity is an age-dependent indicator of immunological fit-ness independently predictive of clinical outcome in Burkittlymphoma
Authors and Affiliates
Johannes Rieken 1, Veronica Bernard 2, Hanno M Witte 1,3, Wolfgang Peter 4, Hartmut Merz 2, Vito Olschewski 1, Lars Hertel 5, Hendrik Lehnert 6, Harald Biersack 1, Nikolas von Bubnoff 1, Alfred C Feller 2, Niklas Gebauer 1;
1 Department of Haematology and Oncology, University Hospital of Schleswig-Holstein, Luebeck, Germany.
2 Hämatopathologie Lübeck, Reference Centre for Lymph Node Pathology and Haematopathology, Lübeck, Germany.
3 Department of Haematology and Oncology, Federal Armed Hospital Ulm, Ulm, Germany.
4 HLA Typing Laboratory of the Stefan-Morsch-Foundation, Birkenfeld, Germany.
5 Department of Neuro- and Bioinformatics, University Hospital of Schleswig-Holstein, Luebeck, Germany.
6 Department of Internal Medicine I, University Hospital of Schleswig-Holstein, Luebeck, Germany.
CBFB-MYH11 fusion neoantigen enables T cell recognition and killing of acute myeloid leukemia
Biernacki MA., et al.
JCI
Journal of Clinical Investigation
September 2020
Authors and Affiliates
Melinda A Biernacki 1,2, Kimberly A Foster 1, Kyle B Woodward 1, Michael E Coon 1, Carrie Cummings 1, Tanya M Cunningham 1, Robson G Dossa 1, Michelle Brault 1, Jamie Stokke 1,3, Tayla M Olsen 1, Kelda Gardner 2, Elihu Estey 1,2, Soheil Meshinchi 1,3, Anthony Rongvaux 1,4, Marie Bleakley 1,3;
1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
2 Department of Medicine.
3 Department of Pediatrics, and.
4 Department of Immunology, University of Washington, Seattle, Washington, USA.
IL-32γ potentiates tumor immunity in melanoma
Gruber T., et al.
JCI Insight
September 2020
Authors and Affiliates
Thomas Gruber 1,2, Mirela Kremenovic 1,2, Hassan Sadozai 1,2, Nives Rombini 1, Lukas Baeriswyl 1, Fabienne Maibach 1, Robert L Modlin 3, Michel Gilliet 4, Diego von Werdt 1,2, Robert E Hunger 5, S Morteza Seyed Jafari 5, Giulia Parisi 6, Gabriel Abril-Rodriguez 6, Antoni Ribas 6, Mirjam Schenk 1;
1 Institute of Pathology, Experimental Pathology, and.
2 Graduate School Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
3 Division of Dermatology, Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
4 Department of Dermatology, Lausanne University Hospital, Lausanne, Switzerland.
5 Department of Dermatology, Inselspital, University Hospital of Bern, University of Bern, Bern, Switzerland.
6 Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, and UCLA Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, USA.
Long-term robustness of a T-cell system emerging from somatic rescue of a genetic block in T-cell development
Authors and Affiliates
Patrick Kury 1, Marita Führer 2, Sebastian Fuchs 3, Myriam R Lorenz 4, Orlando Bruno Giorgetti 5, Shahrzad Bakhtiar 6, Andreas P Frei 3, Paul Fisch 7, Thomas Boehm 5, Klaus Schwarz 8, Carsten Speckmann 9, Stephan Ehl 10;
1 Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Straße 115, 79106 Freiburg, Germany; Faculty of Biology, University of Freiburg, Schaenzlestrasse 1, D-79104 Freiburg, Germany.
2 Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Baden-Wuerttemberg - Hessen, Ulm, Germany.
3 Roche Pharma Research and Early Development, Immunology, Infectious Diseases and Ophthalmology (I2O) Discovery and Translational Area, Roche Innovation Center Basel, Basel, Switzerland.
4 Institute for Transfusion Medicine, University of Ulm, Ulm, Germany.
5 Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics Freiburg, Freiburg, Germany.
6 Division for Pediatric Stem-Cell Transplantation, Immunology and Intensive Medicine, University Hospital Frankfurt, Frankfurt/Main, Germany.
7 Department of Pathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
8 Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Baden-Wuerttemberg - Hessen, Ulm, Germany; Institute for Transfusion Medicine, University of Ulm, Ulm, Germany.
9 Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Straße 115, 79106 Freiburg, Germany; Center for Pediatrics, Department of Pediatric Hematology and Oncology, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
10 Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Straße 115, 79106 Freiburg, Germany; CIBBS -Centre for Integrative Biological Signaling Studies, University of Freiburg, Freiburg, Germany. Electronic address: stephan.ehl@uniklinik-freiburg.de.
Diagnosis of Kidney Transplant Rejection by Tracking Donor-reactive T-cell Clones in the Post-Transplant Biopsy, Blood and Urine Samples
Leventhal JR., et al.
Transplantation
September 2020
Authors and Affiliates
Joseph R. Leventhal 1, Yuvaraj Sambandam 1, Jie He 1, Xuemei Huang 1, Lorenzo Gallon 1, James Mathew 1;
1 Surgery, Northwestern University, Chicago, IL, United States.
Radiation induces dynamic changes to the T cell repertoire in renal cell carcinoma patients
Authors and Affiliates
Jacky Chow 1, Nicholas C Hoffend 1, Scott I Abrams 1, Thomas Schwaab 1,2, Anurag K Singh 3, Jason B Muhitch 4,2;
1 Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263.
2 Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263.
3 Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263.
4 Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263; jason.muhitch@roswellpark.org.