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Epigenetic Suppression of Transgenic T-cell Receptor Expression via Gamma-Retroviral Vector Methylation in Adoptive Cell Transfer Therapy

Nowicki TS., et al.
Cancer Discovery
September 2020
Authors and Affiliates
Theodore S Nowicki 1, Colin Farrell 2, Marco Morselli 3, Liudmilla Rubbi 4, Katie M Campbell 5, Mignonette H Macabali 6, Beata Berent-Maoz 5, Begona Comin-Anduix 7, Matteo Pellegrini 8, Antoni Ribas 9; 1 Pediatrics, Hematology-Oncology, University of California Los Angeles 2 Human Genetics, University of California Los Angeles. 3 Molecular, Cell and Developmental Biology, University of California Los Angeles. 4 Molecular, Cell, and Developmental Biology, University of California Los Angeles. 5 Department of Medicine, University of California Los Angeles. 6 Department of Medicine, Division of Hematology-Oncology, University of California Los Angeles. 7 Surgical Oncology, University of California Los Angeles. 8 Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles. 9 Department of Medicine, Jonsson Comprehensive Cancer Center at University of California, Los Angeles, Los Angeles.

Augmented Lipocalin-2 is Associated with COPD and Counteracts Lung Adenocarcinoma Development

Treekitkarnmongkol W., et al.
American Journal of Respiratory and Critical Care Medicine
September 2020
Authors and Affiliates
Warapen Treekitkarnmongkol 1, Maya Hassane 2, Ansam Sinjab 1, Kyle Chang 3, Kieko Hara 1, Zahraa Rahal 4, Jiexin Zhang 5, Wei Lu 1, Smruthy Sivakumar 3, Tina L McDowell 1 3, Jacob Kantrowitz 6, Jianling Zhou 1, Wenhua Lang 1, Li Xu 1, Joshua K Ochieng 1, Sayuri Nunomura-Nakamura 7, Shanshan Deng 8, Carmen Behrens 1, Maria Gabriela Raso 1, Junya Fukuoka 9, Alexandre Reuben 10, Edwin J Ostrin 8, Edwin Parra 1, Luisa M Solis 1, Avrum E Spira 6, Florencia McAllister 11, Tina Cascone 10, Ignacio I Wistuba 1, Seyed Javad Moghaddam 8, Paul A Scheet 1, Junya Fujimoto 1, Humam Kadara 12; 1 University of Texas MD Anderson Cancer Center, 4002, Translational Molecular Pathology, Houston, Texas, United States. 2 American University of Beirut Faculty of Medicine, 66978, Biochemistry and Molecular Genetics, Beirut, Lebanon. 3 University of Texas MD Anderson Cancer Center, 4002, Epidemiology, Houston, Texas, United States. 4 American University of Beirut Faculty of Medicine, 66978, Beirut, Lebanon. 5 University of Texas MD Anderson Cancer Center, 4002, Bioinformatics and Computer Biology, Houston, Texas, United States. 6 Boston University, 1846, Medicine, Boston, Massachusetts, United States. 7 Nagasaki University School of Medicine Graduate School of Biomedical Sciences, 200674, Nagasaki, Japan. 8 University of Texas MD Anderson Cancer Center, 4002, Pulmonary Medicine, Houston, Texas, United States. 9 Nagasaki University School of Medicine Graduate School of Biomedical Sciences, 200674, Department of Pathology, Nagasaki, Japan. 10 University of Texas MD Anderson Cancer Center, 4002, Thoracic/Head and Neck Medical Oncology, Houston, Texas, United States. 11 University of Texas MD Anderson Cancer Center, 4002, Clinical Cancer Prevention, Houston, Texas, United States. 12 University of Texas MD Anderson Cancer Center, 4002, Translational Molecular Pathology, Houston, Texas, United States

Clonality and antigen-specific responses shape the prognostic effects of tumor-infiltrating T cells in ovarian cancer

Tsuji T., et al.
Oncotarget
September 2020
Authors and Affiliates
Takemasa Tsuji 1,2, Kevin H Eng 3,4,2, Junko Matsuzaki 1, Sebastiano Battaglia 1, J Brian Szender 5, Anthony Miliotto 1, Sacha Gnjatic 6, Wiam Bshara 7, Carl D Morrison 7, Shashikant Lele 5, Ryan O Emerson 8, Jianmin Wang 3, Song Liu 3, Harlan Robins 8, Amit A Lugade 1, Kunle Odunsi 1,5; 1 Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 2 These authors contributed equally to this work. 3 Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 4 Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 5 Department of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 6 Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 7 Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. 8 Adaptive Biotechnologies, Seattle, WA, USA.

B Cells Improve Overall Survival in HPV-Associated Squamous Cell Carcinomas and Are Activated by Radiation and PD-1 Blockade

Kim SS., et al.
Clinical Cancer Research
September 2020
Authors and Affiliates
Sangwoo S Kim 1,2, Sarek Shen 2,3, Sayuri Miyauchi 1, P Dominick Sanders 1, Ida Franiak-Pietryga 1, Loren Mell 1, J Silvio Gutkind 4, Ezra E W Cohen 5, Joseph A Califano 3, Andrew B Sharabi 6; 1 Department of Radiation Medicine and Applied Sciences, Moores Cancer Center, University of California, San Diego, La Jolla, California. 2 School of Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, California. 3 Department of Surgery, Division of Otolaryngology, Moores Cancer Center, University of California, San Diego, La Jolla, California. 4 Department of Pharmacology, Moores Cancer Center, University of California, San Diego, La Jolla, California. 5 Department of Medicine, Division of Hematology-Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, California. 6 Department of Radiation Medicine and Applied Sciences, Moores Cancer Center, University of California, San Diego, La Jolla, California

Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma

Hegde M., et al.
Nature Communications
September 2020
Authors and Affiliates
Meenakshi Hegde 1,2,3, Sujith K Joseph 4,5,6, Farzana Pashankar 7, Christopher DeRenzo 4,5,6, Khaled Sanber 4,5,6,8, Shoba Navai 4,5,6, Tiara T Byrd 4,5,6, John Hicks 9, Mina L Xu 10, Claudia Gerken 4,5,6, Mamta Kalra 4,5,6, Catherine Robertson 5, Huimin Zhang 5, Ankita Shree 4,5,6, Birju Mehta 5, Olga Dakhova 5, Vita S Salsman 4,5,6, Bambi Grilley 4,5,6, Adrian Gee 4,5,6, Gianpietro Dotti 11,12, Helen E Heslop 4,5,6,8, Malcolm K Brenner 4,5,6,8, Winfried S Wels 13,14,15, Stephen Gottschalk 4,5,6,9, Nabil Ahmed 16,17,18,19; 1 Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu. 2 Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu. 3 Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. mghegde@bcm.edu. 4 Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. 5 Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. 6 Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. 7 Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA. 8 Department of Medicine, Baylor College of Medicine, Houston, TX, USA. 9 Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA. 10 Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. 11 Department of Microbiology and Immunology at University of North Carolina, Chapel Hill, NC, USA. 12 Lineberger Cancer Center at University of North Carolina, Chapel Hill, NC, USA. 13 Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany. 14 German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt, Germany. 15 Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany. 16 Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. 17 Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. 18 Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. 19 Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA

T cell fraction impacts oncologic outcomes in human papillomavirus associated oropharyngeal squamous cell carcinoma

Van Abel KM., et al.
September 2020
Authors and Affiliates
Kathryn M Van Abel 1, David M Routman 2, Eric J Moore 3, Daniel J Ma 2, Linda X Yin 3, Paul A Fields 4, Matt Schofield 4, Kathleen R Bartemes 3, Kyriakos Chatzopoulos 5, Daniel L Price 3, Jeffrey R Janus 3, Jan L Kasperbauer 3, Katharine A Price 6, Ashish V Chintakuntlawar 6, Michelle A Neben-Wittich 2, Robert L Foote 2, Joaquin J Garcia 5; 1 Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: vanabel.kathryn@mayo.edu. 2 Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA. 3 Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN 55905, USA. 4 Adaptive Biotechnologies, Seattle, WA 98102, USA; Department of Pathology and Clinical Medicine, Mayo Clinic, Rochester, MN 55905, USA. 5 Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA. 6 Department of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA.

A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response

Li H., et al.
JCI Insight
September 2020
Authors and Affiliates
Hao-Dong Li 1, Changzheng Lu 1, He Zhang 2, Qing Hu 1, Junqiu Zhang 3, Ileana C. Cuevas 1, Subhransu S. Sahoo 1, Mitzi Aguilar 1, Elizabeth G. Maurais 1, Shanrong Zhang 4, Xiaojing Wang 4, Esra A. Akbay 1,5, Guo-Min Li 3,4, Bo Li 5,6,7, Prasad Koduru 1, Peter Ly 1,5,8, Yang-Xin Fu 1,5,7, and Diego H. Castrillon 1,5,9; 1 Department of Pathology, 2 Quantitative Biomedical Research Center, Department of Population and Data Sciences, 3 Department of Radiation Oncology, 4 Advanced Imaging Research Center, 5 Simmons Comprehensive Cancer Center, 6 Lyda Hill Department of Bioinformatics, 7 Department of Immunology, 8 Department of Cell Biology, and 9 Department of Obstetrics & Gynecology, UT Southwestern Medical Center, Dallas, Texas, USA.

Deciphering and predicting CD4+ T cell immunodominance of influenza virus hemagglutinin

Cassotta A., et al.
Journal of Experimental Medicine
September 2020
Authors and Affiliates
Antonino Cassotta 1,2, Philipp Paparoditis 1, Roger Geiger 1, Ramgopal R Mettu 3, Samuel J Landry 4, Alessia Donati 1, Marco Benevento 1, Mathilde Foglierini 1,5, David J M Lewis 6, Antonio Lanzavecchia 1, Federica Sallusto 1,2; 1 Institute for Research in Biomedicine, Università della Svizzera italiana, Faculty of Biomedical Sciences, Bellinzona, Switzerland. 2 Institute of Microbiology, ETH Zürich, Zürich, Switzerland. 3 Department of Computer Science, Tulane University, New Orleans, LA, USA 4 Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA, USA 5 Swiss Institute of Bioinformatics, Lausanne, Switzerland. 6 Surrey Clinical Research Centre, University of Surrey, Guildford, UK.

The safety and clinical effects of administering a multiantigen-targeted T cell therapy to patients with multiple myeloma

Premal DL., et al.
Science Translational Medicine
September 2020
Authors and Affiliates
Premal D Lulla 1, Ifigeneia Tzannou 2, Spyridoula Vasileiou 2, George Carrum 2, Carlos A Ramos 2, Rammurti Kamble 2, Tao Wang 2, Mengfen Wu 2, Mrinalini Bilgi 2, Adrian P Gee 2, Shivani Mukhi 2, Betty Chung 2, Linghua Wang 2, Ayumi Watanabe 2, Manik Kuvalekar 2, Mira Jeong 2, Yumei Li 2, Shamika Ketkar 2, Matthew French-Kim 2, Bambi Grilley 2, Malcolm K Brenner 2, Helen E Heslop 2, Juan F Vera 2, Ann M Leen 2; 1 Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX 77030, USA 2 Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX 77030, USA

An Integrated Multi-omic Single-Cell Atlas of Human B Cell Identity

Glass DR., et al.
Immunity
September 2020
Authors and Affiliates
David R Glass 1, Albert G Tsai 2, John Paul Oliveria 3, Felix J Hartmann 2, Samuel C Kimmey 4, Ariel A Calderon 1, Luciene Borges 2, Marla C Glass 5, Lisa E Wagar 6, Mark M Davis 6, Sean C Bendall 7; 1 Immunology Graduate Program, Stanford University, Stanford, CA, 94305, USA; Department of Pathology, Stanford University, Stanford, CA, 94305, USA. 2 Department of Pathology, Stanford University, Stanford, CA, 94305, USA. 3 Department of Pathology, Stanford University, Stanford, CA, 94305, USA; Department of Medicine, Division of Respirology, McMaster University, Hamilton, ON, L8S4K1, Canada. 4 Department of Pathology, Stanford University, Stanford, CA, 94305, USA; Department of Developmental Biology, Stanford University, Stanford CA, 94305, USA. 5 Department of Surgery, Stanford University, Stanford CA, 94305, USA. 6 Department of Microbiology and Immunology, Stanford University, Stanford CA, 94305, USA. 7 Immunology Graduate Program, Stanford University, Stanford, CA, 94305, USA; Department of Pathology, Stanford University, Stanford, CA, 94305, USA.
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