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Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities

Subudhia et al.
Papers
Proceedings of the National Academy of Sciences
October 2016
immuneAccess
Authors and Affiliates
Sumit K. Subudhia,1, Ana Aparicioa,1, Jianjun Gaoa, Amado J. Zuritaa, John C. Araujoa, Christopher J. Logothetisa, Salahaldin A. Tahira, Brinda R. Korivib, Rebecca S. Slackc, Luis Venced, Ryan O. Emersone, Erik Yuskoe, Marissa Vignalie, Harlan S. Robinse,f, Jingjing Sung, James P. Allisond,g,2, and Padmanee Sharmaa,d,g,2 aDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; bDepartment of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; cDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; dImmunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; eAdaptive Biotechnologies, Seattle, WA 98102; fFred Hutchinson Cancer Research Center, Seattle, WA 98102; and gDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030

Anti-PD-1 increases the clonality and activity of tumor infiltrating antigen specific T cells induced by a potent immune therapy consisting of vaccine and metronomic cyclophosphamide

Weir et al
Journal for ImmunoTherapy of Cancer
Papers
October 2016
Authors and Affiliates
Genevieve M. Weir1*, Olga Hrytsenko1, Tara Quinton1, Neil L. Berinstein2,3, Marianne M. Stanford1,4 and Marc Mansour1 1 Immunovaccine Inc., 1344 Summer St., Halifax, NS B3H 0A8, Canada. 2 Sunnybrook Research Institute, 2075 Bayview Ave., Toronto, ON M4N 3M5, Canada. 3 University of Toronto, 27 King’s College Cir, Toronto, ON M5S 1A1, Canada. 4 Department of Microbiology & Immunology, Dalhousie University, 5850 College St., Room 7C, Halifax, NS B3H 4R2, Canada.

Efficient Culture of Human Naive and Memory B Cells for Use as APCs

Su et al.
Journal of Immunology
Papers
October 2016
immuneAccess
Authors and Affiliates
Kuei-Ying Su,*,†,1 Akiko Watanabe,*,1 Chen-Hao Yeh,* Garnett Kelsoe,*,‡ and Masayuki Kuraoka* *Department of Immunology, Duke University, Durham, NC 27710; †Tzu Chi Med- ical Center, Hualien 970, Taiwan; and ‡Human Vaccine Institute, Duke University, Durham, NC 27710

Suppression by Tfr cells leads to durable and selective inhibition of B cell effector function

Sage et al.
Nature Immunology
Papers
October 2016
Authors and Affiliates
Peter T Sage1,2, Noga Ron-Harel3, Vikram R Juneja1,2, Debattama R Sen4, Seth Maleri1,2, Waradon Sungnak2,5, Vijay K Kuchroo2,5, W Nicholas Haining4, Nicolas Chevrier6, Marcia Haigis3 & Arlene H Sharpe1,2,7 1Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA. 2Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts, USA. 3Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA. 4Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. 5Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. 6FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, USA. 7Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming

Tleugabulova et al.
Journal of Immunology
Papers
October 2016
Authors and Affiliates
Mayra Cruz Tleugabulova*, Nichole K. Escalante*, Shenglou Deng†, Stephanie Fieve*, June Ereño-Orbea‡, Paul B. Savage†, Jean-Philippe Julien*,‡,§ and Thierry Mallevaey* *Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; †Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602; ‡The Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada; and §Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada

Deep Sequencing of T-Cell Receptor DNA as a biomarker of clonally expanded TILs in breast cancer after immunotherapy

Page et al.
Cancer Immunology Research
Papers
September 2016
immuneAccess
Authors and Affiliates
David B. Page1,2, Jianda Yuan1, David Redmond3, Y Hanna Wen1, Jeremy C. Durack1, Ryan Emerson4, Stephen Solomon1, Zhiwan Dong1, Phillip Wong1, Christopher Comstock1, Adi Diab5, Janice Sung1, Majid Maybody1, Elizabeth Morris1, Edi Brogi1, Monica Morrow1, Virgilio Sacchini1, Olivier Elemento3, Harlan Robins6, Sujata Patil1, James P. Allison5, Jedd D. Wolchok1,3, Clifford Hudis1,3, Larry Norton1,3, and Heather McArthur1,3 1Medical Oncology, Providence Portland Medical Center / Robert W. Franz Cancer Research Center and Earl A. Chiles Research Institute; 2Memorial Sloan-Kettering Cancer Center; 3Weill Cornell Medical College 4Adaptive Biotechnologies; 5Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center; 6Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medical College; 7Human Biology Division, Fred Hutchinson Cancer Research Center; 8Immunology, University of Texas MD Anderson Cancer Center; 9Ludwig Center for Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center; 10Medicine, Breast Medicine Service, Memorial Sloan-Kettering Cancer Center

ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells

Boddupalli et al.
Papers
The Journal of Clinical Investigation
September 2016
Authors and Affiliates
Chandra Sekhar Boddupalli1, Shiny Nair1, Simon M. Gray2, Heba N. Nowyhed3, Rakesh Verma1. Joanna A. Gibson4,Clara Abraham1, Deepak Narayan5, Juan Vasquez6, Catherine C. Hedrick3, Richard A. Flavell2,7, Kavita M. Dhodapkar6, Susan M. Kaech2,7, and Madhav V. Dhodapkar1,2 1Department of Medicine, and 2Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA. 3La Jolla Institute for Allergy and Immunology, Division of Inflammation Biology, La Jolla, California, USA. 4Department of Pathology, 5Department of Surgery, 6Department of Pediatrics, and 7Howard Hughes Medical Institute, Yale School of Medicine, New Haven, Connecticut, USA.

The T-cell receptor repertoire influences the tumor microenvironment and is associated with survival in aggressive B-cell lymphoma

Keane et al.
Clinical Cancer Research
Papers
September 2016
immuneAccess
Authors and Affiliates
1,2Colm Keane, 1,2Clare Gould, 1Kimberley Jones, 3David Hamm, 5,6Dipti Talaulikar, 1Jonathan Ellis, 1Frank Vari, 2,7Simone Birch 1Erica Han, 2Peter Wood, 1Kim-Anh Le-Cao, 4Michael R. Green, 1Pauline Crooks, 5Sanjiv Jain, 1,2Josh Tobin, 1Raymond J. Steptoe, 1,2Maher K. Gandhi. 1University of Queensland Diamantina Institute, Translational Research Institute, University of Queensland, Australia;2Princess Alexandra Hospital, Brisbane, Queensland, Australia; 3Adaptive Biotechnologies, Seattle, WA, USA, 4Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska, USA. 5Canberra Hospital, Canberra, Australian Capital Territory; 6Australian National University Medical School, Australian Capital Territory; 7Pathology Queensland, Brisbane, Queensland, Australia.

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Kordasti et al.
Blood
Papers
September 2016
Authors and Affiliates
Shahram Kordasti,1,2,* Benedetta Costantini,1,2,* Thomas Seidl,1,* Pilar Perez Abellan,2 Marc Martinez Llordella,3 Donal McLornan,2 Kirsten E. Diggins,4 Austin Kulasekararaj,2 Cinzia Benfatto,1 Xingmin Feng,5 Alexander Smith,1,2 Syed A. Mian,1 Rossella Melchiotti,6 Emanuele de Rinaldis,6 Richard Ellis,6 Nedyalko Petrov,6 Giovanni A. M. Povoleri,3 Sun Sook Chung,1 N. Shaun B. Thomas,1 Farzin Farzaneh,1 Jonathan M. Irish,4 Susanne Heck,6 Neal S. Young,5 Judith C. W. Marsh,1,2 and Ghulam J. Mufti1,2 1Department of Haematological Medicine, King’s College London, London, United Kingdom; 2Haematological Medicine, King’s College Hospital, London, United Kingdom; 3Division of Transplantation Immunology & Mucosal Biology, King’s College London, London, United Kingdom; 4Department of Cancer Biology, Vanderbilt University, Nashville, TN; 5Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; and 6National Institute for Health Research Biomedical Research Centre, King’s College London, London, United Kingdom

Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease

Henriksen et al.
Journal of Hepatology
Papers
September 2016
Authors and Affiliates
Eva Kristine Klemsdal Henriksen1,2,3,4, Kristin Kaasen Jørgensen1,5, Fatemeh Kaveh3,4,6, Kristian Holm1,2,3,4, David Hamm7, Johanna Olweus3,8,9, Espen Melum1,2,3,10, Brian K. Chung1,4,13, Tor J. Eide4,11, Knut E.A. Lundin10,12, Kirsten Muri Boberg1,3,4,10, Tom H. Karlsen1,2,3,4,10,Gideon M. Hirschfield13, Evaggelia Liaskou13,⇑ 1Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; 2Research Institute of Internal Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; 3K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 4Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; 5Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; 6Department of Medical Genetics, Oslo University Hospital Ullevål, Oslo, Norway; 7Adaptive Biotechnologies Corp., Seattle, WA, USA; 8Department of Cancer Immunology, Institute for Cancer Research,Oslo University Hospital Radiumhospitalet, Oslo, Norway; 9K.G. Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 10Section of Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Medicine and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway; 11Department of Pathology, Oslo University Hospital Rikshospitalet, Oslo, Norway; 12Centre for Immune Regulation, Faculty of Medicine, University of Oslo, Oslo, Norway; 13Centre for Liver Research and NIHR Birmingham Biomedical Research Unit, Institute of Biomedical Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK
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