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Immunotherapy targeting different immune compartments in combination with radiation therapy induces regression of resistant tumors

Rudqvist N, et al.
Nature Communications
August 2023
Authors and Affiliates
Nils-Petter Rudqvist 1,2,3, Maud Charpentier 1, Claire Lhuillier 1,4, Erik Wennerberg 1,5, Sheila Spada 1, Caroline Sheridan 6, Xi Kathy Zhou 7, Tuo Zhang 8, Silvia C Formenti 1, Jennifer S Sims 9,10, Alicia Alonso 6, Sandra Demaria 11,12; 1 Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, 10065, USA. 2 Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson, Houston, TX, 77030, USA. 3 Department of Immunology, University of Texas MD Anderson, Houston, TX, 77030, USA. 4 Department of Immuno-Oncology, Sanofi, 94403, Vitry-sur-Seine, France. 5 Division of Radiotherapy and Imaging, Institute of Cancer Research, London, SM2 5NG, UK. 6 Department of Medicine, Weill Cornell Medicine, New York, NY, 10065, USA. 7 Division of Biostatistics, Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, 10065, USA. 8 Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, 10065, USA. 9 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. 10 Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. 11 Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, 10065, USA. szd3005@med.cornell.edu. 12 Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10065, USA. szd3005@med.cornell.edu.

TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy

Tvingsholm SA, et al.
Journal for ImmunoTherapy of Cancer
August 2023
Authors and Affiliates
Siri Amanda Tvingsholm 1, Marcus Svensson Frej 2, Vibeke Mindahl Rafa 1, Ulla Kring Hansen 2, Maria Ormhøj 1, Alexander Tyron 1, Agnete W P Jensen 3, Mohammad Kadivar 1, Amalie Kai Bentzen 1, Kamilla K Munk 1, Gitte N Aasbjerg 1, Jeppe S H Ternander 2, Christina Heeke 1, Tripti Tamhane 1, Christian Schmess 4, Samuel A Funt 5, Julie Westerlin Kjeldsen 3, Anders Handrup Kverneland 3, Özcan Met 6, Arianna Draghi 3, Søren Nyboe Jakobsen 1, Marco Donia 3, Inge Marie Svane 3, Sine Reker Hadrup 7; 1 Department of Health Technology, Technical University of Denmark, Lyngby, Denmark. 2 PokeAcell Aps, BioInnovation Institute, Copenhagen, Denmark. 3 National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Herlev Hospital, Herlev, Denmark. 4 NMI Natural and Medical Science Institute, University of Tübingen, Tubingen, Germany. 5 Deptartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. 6 National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Herlev Hospital, Copenhagen, Denmark. 7 Department of Health Technology, Technical University of Denmark, Lyngby, Denmark sirha@dtu.dk.

T-cell tolerant fraction as a predictor of immune-related adverse events

Ostmeyer J, et al.
Journal for ImmunoTherapy of Cancer
August 2023
Authors and Affiliates
Jared Ostmeyer 1, Jason Y Park 2, Mitchell S von Itzstein 3, David Hsiehchen 3,4, Farjana Fattah 4, Mary Gwin 3, Rodrigo Catalan 4, Shaheen Khan 2, Prithvi Raj 5, Edward K Wakeland 5, Yang Xie 1,4, David E Gerber 6,3,4; 1 Peter O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, Texas, USA. 2 Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. 3 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. 4 Harold C Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA. 5 Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. 6 Peter O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, Texas, USA David.Gerber@utsouthwestern.edu.

mRNA vaccination boosts S-specific T cell memory and promotes expansion of CD45RAint TEMRA-like CD8+ T cells in COVID-19 recovered individuals

Mayer-Blackwell K, et al.
Cell Reports Medicine
August 2023
Authors and Affiliates
Koshlan Mayer-Blackwell 1, Heeju Ryu 1, Amy S Codd 1, K Rachael Parks 1, Hugh R MacMillan 1, Kristen W Cohen 1, Terri L Stewart 1, Aaron Seese 1, Maria P Lemos 1, Stephen C De Rosa 1, Julie L Czartoski 1, Zoe Moodie 1, Long T Nguyen 1, Donald J McGuire 2, Rafi Ahmed 2, Andrew Fiore-Gartland 1, M Juliana McElrath 3, Evan W Newell 4; 1 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. 2 Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA. 3 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. Electronic address: jmcelrat@fredhutch.org. 4 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA. Electronic address: enewell@fredhutch.org.

Rigorous benchmarking of T-cell receptor repertoire profiling methods for cancer RNA sequencing

Peng K, et al.
Briefings in Bioinformatics
August 2023
Authors and Affiliates
Kerui Peng 1, Theodore S Nowicki 2,3, Katie Campbell 4, Mohammad Vahed 1, Dandan Peng 5, Yiting Meng 1, Anish Nagareddy 6, Yu-Ning Huang 1, Aaron Karlsberg 1, Zachary Miller 7, Jaqueline Brito 1, Brian Nadel 1,8, Victoria M Pak 9,10, Malak S Abedalthagafi 11,12, Amanda M Burkhardt 1, Houda Alachkar 1, Antoni Ribas 13, Serghei Mangul 1,5; 1 Department of Clinical Pharmacy, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USA. 2 Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of California, Los Angeles, CA, USA. 3 Department of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, CA, USA. 4 Department of Medicine, Division of Hematology-Oncology, University of California, Los Angeles, CA, USA. 5 Department of Quantitative and Computational Biology, USC Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, USA. 6 Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA. 7 Department of Pharmaceutical Sciences, USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, USA. 8 Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, USA. 9 Emory Nell Hodgson School of Nursing, Emory University, Atlanta, GA, USA. 10 Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA. 11 Department of Pathology & Laboratory Medicine, Emory University Hospital, Atlanta, GA, USA. 12 King Salman Center for Disability Research, Riyadh, Saudi Arabia. 13 Departments of Medicine (Hematology-Oncology), Surgery (Surgical Oncology) and Molecular & Medical Pharmacology, University of California, Los Angeles, CA, USA.

The overlap of skin and blood T-cell clones in early-stage mycosis fungoides

Joffe D, et al.
Blood Advances
August 2023
Authors and Affiliates
Daniel Joffe 1, Safiyyah Bhatti 1, Lauren Banner 1, Romsin Zaya 1, Laura Gleason 1, Anjali Mishra 2, Ilan R Kirsch 3, Pierluigi Porcu 4, Neda Nikbakht 1; 1 Thomas Jefferson University, Philadelphia, Pennsylvania, United States. 2 Thomas Jefferson University and Sidney Kimmel Cancer Center, Philadelphia, Pennsylvania, United States. 3 Adaptive Biotechnologies, Seattle, Washington, United States. 4 Sidney Kimmel Cancer Center, Philadelphia, Pennsylvania, United States.

Identification of human exTreg cells as CD16+CD56+ cytotoxic CD4+ T cells

Freuchet A, et al.
Nature Immunology
August 2023
Authors and Affiliates
Antoine Freuchet 1, Payel Roy 1, Sujit Silas Armstrong 1, Mohammad Oliaeimotlagh 2, Sunil Kumar 2, Marco Orecchioni 1,2, Amal J Ali 1, Amir Khan 2, Jeffrey Makings 1, Qingkang Lyu 2, Holger Winkels 3,4, Erpei Wang 1, Christopher Durant 1, Yanal Ghosheh 1, Rishab Gulati 1, Felix Nettersheim 1, Klaus Ley 5,6; 1 La Jolla Institute for Immunology, La Jolla, CA, USA. 2 Immunology Center of Georgia, Augusta University, Augusta, GA, USA. 3 University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic III for Internal Medicine, Cologne, Germany. 4 Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. 5 La Jolla Institute for Immunology, La Jolla, CA, USA. kley@augusta.edu. 6 Immunology Center of Georgia, Augusta University, Augusta, GA, USA. kley@augusta.edu.

HLA variants and TCR diversity against SARS-CoV-2 in the pre-COVID-19 era

Buhler S, et al.
HLA
August 2023
Authors and Affiliates
Stéphane Buhler 1, Zuleika Calderin Sollet 1, Florence Bettens 1, Antonia Schäfer 1, Marc Ansari 2,3, Sylvie Ferrari-Lacraz 1, Jean Villard 1; 1 Transplantation Immunology Unit and National Reference Laboratory for Histocompatibility, Department of Diagnostic, Geneva University Hospitals, Geneva, Switzerland. 2 CANSEARCH Research Platform for Pediatric Oncology and Hematology, Faculty of Medicine, Department of Pediatrics, Gynecology and Obstetrics, University of Geneva, Geneva, Switzerland. 3 Division of Pediatric Oncology and Hematology, Department of Women, Child and Adolescent, University Geneva Hospitals, Geneva, Switzerland.

Tissue-specific features of the T cell repertoire after allogeneic hematopoietic cell transplantation in human and mouse

DeWolf S, et al.
Science Translational Medicine
August 2023
Authors and Affiliates
Susan DeWolf 1, Yuval Elhanati 2, Katherine Nichols 3, Nicholas R Waters 3, Chi L Nguyen 3, John B Slingerland 3, Natasia Rodriguez 4, Olga Lyudovyk 2, Paul A Giardina 3, Anastasia I Kousa 3, Hana Andrlová 3, Nick Ceglia 2, Teng Fei 5, Rajya Kappagantula 6,7, Yanyun Li 7, Nathan Aleynick 7, Priscilla Baez 4, Rajmohan Murali 7, Akimasa Hayashi 7,8, Nicole Lee 3, Brianna Gipson 3, Madhumitha Rangesa 4, Zoe Katsamakis 3, Anqi Dai 3, Amanda G Blouin 7, Maria Arcila 7, Ignas Masilionis 9, Ronan Chaligne 9, Doris M Ponce 4,10, Heather J Landau 4,10, Ioannis Politikos 4,10, Roni Tamari 4,10, Alan M Hanash 4,10,11, Robert R Jenq 12, Sergio A Giralt 4,10, Kate A Markey 4,13,14, Yanming Zhang 7, Miguel-Angel Perales 4,10, Nicholas D Socci 15, Benjamin D Greenbaum 2,16, Christine A Iacobuzio-Donahue 6, Travis J Hollmann 7,17, Marcel R M van den Brink 3,4,10, Jonathan U Peled 4,10; 1 Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 2 Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 3 Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 4 Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 5 Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 6 David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 7 Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 8 Department of Pathology, Kyorin University, Mitaka City, Tokyo, Japan. 9 Program for Computational and System Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 10 Weill Cornell Medical College, New York, NY, USA. 11 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 12 Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 13 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 14 Division of Medical Oncology, University of Washington, Seattle, WA, USA. 15 Bioinformatics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 16 Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, Weill Cornell Medical College, New York, NY, USA. 17 Bristol Myers Squibb, Lawrenceville, NJ 08540, USA.

Health Consequences of Thymus Removal in Adults

Kooshesh KA, et al.
New England Journal of Medicine
August 2023
Authors and Affiliates
Kameron A Kooshesh 1, Brody H Foy 1, David B Sykes 1, Karin Gustafsson 1, David T Scadden 1; 1 From the Centers for Regenerative Medicine (K.A.K., D.B.S., K.G., D.T.S.) and Systems Biology (B.H.F.), Massachusetts General Hospital, the Harvard Stem Cell Institute (K.A.K., K.G., D.T.S.), the Department of Stem Cell and Regenerative Biology, Harvard University (K.A.K., K.G., D.T.S.), and Harvard Medical School (K.A.K., B.H.F., D.B.S., K.G., D.T.S.) - all in Boston.
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