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Luis A. Rojas #1,2, Zachary Sethna #1,2, Kevin C. Soares 2,3, Cristina Olcese 2, Nan Pang 2, Erin Patterson 2, Jayon Lihm 4, Nicholas Ceglia 4, Pablo Guasp 1,2, Alexander Chu 4, Rebecca Yu 1,2, Adrienne Kaya Chandra 1,2, Theresa Waters 1,2, Jennifer Ruan 1,2, Masataka Amisaki 1,2, Abderezak Zebboudj 1,2, Zagaa Odgerel 1,2, George Payne 1,2, Evelyna Derhovanessian 5, Felicitas Müller 5, Ina Rhee 6, Mahesh Yadav 6, Anton Dobrin 7,8, Michel Sadelain 7,8, Marta Łuksza 9, Noah Cohen 10, Laura Tang 11, Olca Basturk 11, Mithat Gönen 12, Seth Katz 13, Richard Kinh Do13, Andrew S. Epstein 14, Parisa Momtaz 14, Wungki Park 3,14, Ryan Sugarman 14, Anna M. Varghese 14, Elizabeth Won 14, Avni Desai 14, Alice C. Wei 2,3, Michael I. D’Angelica 2,3, T. Peter Kingham 2,3, Ira Mellman 6, Taha Merghoub 15, Jedd D. Wolchok 15, Ugur Sahin 5, Özlem Türeci 5,16, Benjamin D. Greenbaum (corresponding author) 4,17, William R. Jarnagin 2,3, Jeffrey Drebin 2,3, Eileen M. O’Reilly 3,14, and Vinod P. Balachandran (corresponding author) 1,2,3; 1 Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY USA. 2 Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY USA. 3 David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY USA. 4 Computational Oncology Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY USA. 5 BioNTech, Mainz, Germany. 6 Genentech, San Francisco, CA USA. 7 Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY USA. 8 Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY USA. 9 Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY USA. 10 Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY USA. 11 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY USA. 12 Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY USA. 13 Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY USA. 14 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY USA. 15 Meyer Cancer Center, Weill Cornell Medicine, Weill Cornell Medical College, New York, NY USA. 16 HI-TRON, Helmholtz Institute for Translational Oncology, Mainz, Germany. 17 Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, Weill Cornell Medical College, New York, NY USA.

Raphael Genolet 1,2,4,∗ Sara Bobisse 1,2, Johanna Chiffelle 1,2, Marion Arnaud 1,2, Rémy Petremand 1,2, Lise Queiroz 1,2, Alexandra Michel 1,2, Patrick Reichenbach 1, Julien Cesbron 1,2 Aymeric Auger 1,2, Petra Baumgaertner 1,2, Philippe Guillaume 1,2, Julien Schmidt 1,2, Melita Irving 1, Lana E. Kandalaft1,2, Daniel E. Speiser 1, George Coukos 1,3,∗∗ and Alexandre Harari 1,3,∗∗∗; 1 Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne and Lausanne University Hospital, Lausanne, Switzerland. 2 Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland. Raphael Genolet: hc.vuhc@teloneg.leahpar; George Coukos: hc.vuhc@sokuoc.egroeg; Alexandre Harari: hc.vuhc@irarah.erdnaxela

Mei Xia 1, Azra Blazevic 1, Andrew Fiore-Gartland 2, Daniel F Hoft 1,3; 1 Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, United States. 2 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States. 3 Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO, United States.

Joy A Pai 1, Matthew D Hellmann 2, Jennifer L Sauter 3, Marissa Mattar 4, Hira Rizvi 5, Hyung Jun Woo 6, Nisargbhai Shah 7, Evelyn M Nguyen 8, Fathema Z Uddin 7, Alvaro Quintanal-Villalonga 7, Joseph M Chan 7, Parvathy Manoj 7, Viola Allaj 7, Marina K Baine 3, Umesh K Bhanot 9, Mala Jain 9, Irina Linkov 9, Fanli Meng 6, David Brown 6, Jamie E Chaft 10, Andrew J Plodkowski 11, Mathieu Gigoux 12, Helen H Won 6, Triparna Sen 10, Daniel K Wells 13, Mark T A Donoghue 6, Elisa de Stanchina 4, Jedd D Wolchok 14, Brian Loomis 6, Taha Merghoub 14, Charles M Rudin 15, Andrew Chow 16, Ansuman T Satpathy 17; 1 Department of Pathology, Stanford University, Stanford, CA, USA; Immunology Program, Stanford University, Stanford, CA, USA. 2 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 3 Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 4 Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 5 Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 6 Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 7 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 8 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Cancer Biology Program, Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 9 Precision Pathology Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 10 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA. 11 Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 12 Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 13 Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA; Santa Ana Bio, Alameda, CA, USA. 14 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 15 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA; Druckenmiller Center for Lung Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 16 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA; Ludwig Collaborative and Swim Across America Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: chowa1@mskcc.org. 17 Department of Pathology, Stanford University, Stanford, CA, USA; Immunology Program, Stanford University, Stanford, CA, USA; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA; Stanford Cancer Institute, Stanford University, Stanford, CA, USA; Parker Institute for Cancer Immunotherapy, Stanford University, Stanford, CA, USA. Electronic address: satpathy@stanford.edu.