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Characterisation of T cell receptor repertoires in coeliac disease

Lee LW, et al.
January 2023
Authors and Affiliates
Lik Wee Lee 1, Shahin Shafiani 1, Beryl Crossley 1, Ryan O Emerson 1, David Williamson 1, Anna Bunin 2, Justin Vargas 2, Arnold S Han 2, Ian M Kaplan 1, Peter H R Green 2, Ilan Kirsch 1, Govind Bhagat 3; 1Computational Biology and Translational Medicine, Adaptive Biotechnologies Corp, Seattle, Washington, USA. 2Department of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, New York, USA. 3Department of Pathology and Cell Biology and Department of Medicine, Celiac Disease Center, Columbia University Irving Medical Center, New York, New York, USA. gb96@cumc.columbia.edu

The iR2 regimen (ibrutinib plus lenalidomide and rituximab) for relapsed/refractory DLBCL: A multicentre, non-randomised, open-label phase 2 study.

Ramchandren R, et al.
The Lancet
December 2022
Authors and Affiliates
Radhakrishnan Ramchandren,a Peter Johnson,b Nilanjan Ghosh,c Jia Ruan,d Kirit M. Ardeshna,e Roderick Johnson,f Gregor Verhoef,g David Cunningham,h Sven de Vos,i Shireen Kassam,j Luis Fayad,k John Radford,l Sarah Bailly,m Fritz Offner,n David Morgan,o Javier Munoz,p,s Jerry Ping,q Edith Szafer-Glusman,q Karl Eckert,q Jutta K. Neuenburg,q and Andre Goy a Division of Hematology/Oncology, University of Tennessee Health Science Center, Knoxville, TN, USA b Cancer Research UK Clinical Centre, Southampton General Hospital, Southampton, UK c Levine Cancer Institute, Atrium Health, Charlotte, NC, USA d Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY, USA e University College London/UCL Hospitals, Biomedical Research Centre, London, UK f Leeds Cancer Centre at St. James’s University Hospital, Leeds, UK g Department of Haematology, UZ Leuven – Campus Gasthuisberg, Leuven, Belgium h Gastrointestinal and Lymphoma Unit, The Royal Marsden NHS Foundation Trust – Royal Marsden Hospital, London, UK i Division of Hematology/Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA j Haematology Department, King’s College Hospital, London, UK k Department of Lymphoma-Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX, USA l Division of Cancer Sciences, The University of Manchester and the Christie NHS Foundation Trust, Manchester, UK m Cliniques Universitaires Saint-Luc, Université Catholique de Louvain Brussels, Brussels, Belgium n Department of Clinical Hematology, Universitair Ziekenhuis Gent, Ghent, Belgium o Division of Hematology and Oncology, Vanderbilt-Ingram Cancer Center, Nashville, TN, USA p Department of Hematology, Banner MD Anderson Cancer Center, Gilbert, AZ, USA q Pharmacyclics LLC, an AbbVie Company, South San Francisco, CA, USA r Department of Hematology & Oncology, John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA

Epcoritamab, a Novel, Subcutaneous CD3xCD20 Bispecific T-Cell-Engaging Antibody, in Relapsed or Refractory Large B-Cell Lymphoma: Dose Expansion in a Phase I/II Trial.

Thieblemont C, et al.
Journal of Clinical Oncology
December 2022
Authors and Affiliates
Catherine Thieblemont, MD, PhD1; Tycel Phillips, MD2; Herve Ghesquieres, MD, PhD3; Chan Y. Cheah, MBBS, DMSc4,5;Michael Roost Clausen, MD, PhD6; David Cunningham, MD7; Young Rok Do, MD, PhD8; Tatyana Feldman, MD9;Robin Gasiorowski,MBBS, PhD10; Wojciech Jurczak, MD, PhD11; Tae Min Kim, MD, PhD12; David John Lewis, MD13;Marjolein van der Poel, MD, PhD14; Michelle Limei Poon, MD15; Mariana Cota Stirner, MD, PhD16; Nurgul Kilavuz, MSc17;Christopher Chiu, PhD17; Menghui Chen, PhD17; Mariana Sacchi, MD17; Brian Elliott, MD17; Tahamtan Ahmadi, MD, PhD17;Martin Hutchings, MD, PhD18; and Pieternella J. Lugtenburg, MD, PhD19 1 Assistance Publique & Hopitaux de Paris (APHP), H ˆ opital Saint-Louis, ˆHemato-oncologie, Universit ´ e de Paris, Paris, France ´ 2 University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 3 Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Benite, ´ France 4 Sir Charles Gairdner Hospital, Perth, Australia 5 Division of Internal Medicine, Medical School, University of Western Australia, Perth, Australia 6 Vejle Hospital, Vejle, Denmark 7 The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom 8 Keimyung University Dongsan Medical Center, Daegu, Republic of Korea 9 Hackensack Meridian Health Hackensack University Medical Center, Hackensack, NJ 10Concord Hospital, University of Sydney, Sydney, Australia 11MSC National Research Institute of Oncology, Krakow, Poland ´ 12 Seoul National University Hospital, Seoul, Republic of Korea 13 University Hospitals Plymouth NHS Trust, Derriford Hospital, Plymouth, United Kingdom 14 On behalf of the Lunenburg Lymphoma Phase I/II Consortium-HOVON/ LLPC, Maastricht, Department of Internal Medicine, Division of Hematology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands 15 National University Hospital, Singapore 16 AbbVie, North Chicago, IL 17 Genmab, Princeton, NJ 18 Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark 19 On behalf of the Lunenburg Lymphoma Phase I/II Consortium-HOVON/LLPC, Erasmus MC Cancer Institute, University Medical Center, Department of Hematology, Rotterdam, the Netherlands

NoisET: Noise Learning and Expansion Detection of T-Cell Receptors

Koraichi MB, et al.
Journal of Physical Chemistry A
December 2022
Authors and Affiliates
Meriem Bensouda Koraichi 1, Maximilian Puelma Touzel 2, Andrea Mazzolini 1, Thierry Mora 1, Aleksandra M Walczak 1; 1 Laboratoire de physique de l' École normale supérieure, CNRS, PSL University, Sorbonne Université, and Université de Paris, Paris75005, France. 2 MILA, University of Montreal, MontrealH2S 3H1, Canada.

Reinvigoration of innate and adaptive immunity via therapeutic cellular vaccine for patients with AML

Fujii S, et al.
Molecular Therapy — Oncolytics
December 2022
Authors and Affiliates
Shin-ichiro Fujii 1,2,10, Toyotaka Kawamata 3,10, Kanako Shimizu 1,10, Jun Nakabayashi 4, Satoru Yamasaki 1, Tomonori Iyoda 1, Jun Shinga 1, Hiroshi Nakazato 1, An Sanpei 1, Masami Kawamura 1, Shogo Ueda 1, Jan Dörrie 5, Svetlana Mojsov 6, Madhav V. Dhodapkar 7, Michihiro Hidaka 8, Masanori Nojima 9, Fumitaka Nagamura 9, Shigemi Yoshida 2, Toshio Goto 2, and Arinobu Tojo 3; 1 Laboratory for Immunotherapy, RIKEN Center for Integrative Medical Science (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan 2 Program for Drug Discovery and Medical Technology Platforms, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan 3 Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo (IMSUT): Minato-ku, Tokyo, Japan 4 Department of Mathematics, Tokyo Medical and Dental University, Ichikawa, Chiba, Japan 5 Department of Dermatology, Universitätsklinikum Erlangen, Erlangen, Germany 6 The Rockefeller University, New York, NY, USA 7Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, GA, USA 8Department of Hematology/Oncology, National Hospital Organization Kumamoto Medical Center, Clinical Laboratory: Kumamoto, Kumamoto, Japan 9Center for Translational Research, The Institute of Medical Science, The University of Tokyo (IMSUT), Minato-ku, Tokyo, Japan

Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection

Win TS, et al.
JCI
November 2022
Authors and Affiliates
Thet Su Win 1,2, William J Crisler 1, Beatrice Dyring-Andersen 1, Rachel Lopdrup 2, Jessica E Teague 1, Qian Zhan 1, Victor Barrera 3, Shannan Ho Sui 3, Sotirios Tasigiorgos 2, Naoka Murakami 4, Anil Chandraker 4, Stefan G Tullius 5, Bohdan Pomahac 2, Leonardo V Riella 4, Rachael A Clark 1; 1 Department of Dermatology and. 2 Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. 3 Bioinformatics Core, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. 4 Schuster Transplantation Research Center and. 5 Division of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Cross-reactivity of SARS-CoV-2- and influenza A-specific T cells in individuals exposed to SARS-CoV-2

Chaisawangwong W, et al.
JCI Insight
November 2022
Authors and Affiliates
Worarat Chaisawangwong 1, Hanzhi Wang 2, Theodore Kouo 3, Sebastian F Salathe 1, Ariel Isser 4,5, Joan Glick Bieler 1, Maya L Zhang 2, Natalie K Livingston 4, Shuyi Li 1, Joseph J Horowitz 6, Ron E Samet 7, Israel Zyskind 8, Avi Z Rosenberg 1, Jonathan P Schneck 1,4,5,9,10; 1 Department of Pathology, School of Medicine. 2 Department of Biomedical Engineering, Whiting School of Engineering. 3 Department of Pediatrics, Division of Emergency Medicine. 4 Department of Biomedical Engineering, School of Medicine, and. 5 Institute for Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. 6 ExpressCare Urgent Care, Bel Air, Maryland, USA. 7 Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA. 8 Department of Pediatrics, NYU Langone Medical Center, New York, New York, USA; Maimonides Medical Center, New York, New York, USA. 9 Institute for Nanobiotechnology and. 10 Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir

Benner SE, et al.
JCI Insight
November 2022
Authors and Affiliates
Sarah E Benner 1, Yolanda Eby 1, Xianming Zhu 1, Reinaldo E Fernandez 2, Eshan U Patel 1,3, Jessica E Ruff 1, Feben Habtehyimer 2, Haley A Schmidt 1, Charles S Kirby 1, Sarah Hussain 2, Darin Ostrander 2, Niraj M Desai 4, Sander Florman 5, Meenakshi M Rana 6, Rachel Friedman-Moraco 7, Marcus R Pereira 8, Shikha Mehta 9, Peter Stock 10, Alexander Gilbert 11, Michele I Morris 12, Valentina Stosor 13, Sapna A Mehta 14, Catherine B Small 15, Karthik Ranganna 16, Carlos Aq Santos 17, Saima Aslam 18, Jennifer Husson 19, Maricar Malinis 20, Nahel Elias 21, Emily A Blumberg 22, Brianna L Doby 23,24, Allan B Massie 14, Melissa L Smith 25, Jonah Odim 26, Thomas C Quinn 2,26, Gregory M Laird 27, Robert F Siliciano 2, Dorry L Segev 4,14, Andrew D Redd 2,26, Christine M Durand 2, Aaron Ar Tobian 1; 1 Department of Pathology and. 2 Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. 3 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. 4 Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. 5 Recanati/Miller Transplantation Institute and. 6 Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. 7 Department of Medicine, Emory University, Atlanta, Georgia, USA. 8 Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA. 9 Department of Medicine, University of Alabama Heersink School of Medicine, Birmingham, Alabama, USA. 10 Department of Surgery, University of California, San Francisco, San Francisco, California, USA. 11 Medstar Transplant Institute, Georgetown University School of Medicine, Washington, DC, USA. 12 Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, Florida, USA. 13 Departments of Medicine and Surgery, Divisions of Infectious Diseases and Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. 14 Department of Surgery, New York University Grossman School of Medicine, NYU Langone Health, New York, New York, USA. 15 Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, USA. 16 Department of Medicine, Drexel University, Philadelphia, Pennsylvania, USA. 17 Divison of Infectious Diseases, Rush University Medical Center, Chicago, Illinois, USA. 18 Department of Medicine, University of California, San Diego, San Diego, California, USA. 19 Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA. 20 Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. 21 Department of Surgery and Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. 22 Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. 23 Positive Rhetoric LLC, Bowling Green, Kentucky, USA. 24 Department of Public Health Sciences, College of Health, Education, and Social Transformation, New Mexico State University, Las Cruces, New Mexico, USA. 25 Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, Kentucky, USA. 26 Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA. 27 AccelevirDx, Baltimore, Maryland, USA.

Immunogenomic profiling of lung adenocarcinoma reveals poorly differentiated tumors are associated with an immunogenic tumor microenvironment

Akhave N, et al.
Lung Cancer
November 2022
Authors and Affiliates
Neal Akhave 1, Jiexin Zhang 2, Erin Bayley 3, Meredith Frank 1, Shin-Heng Chiou 4, Carmen Behrens 5, Runzhe Chen 1, Xin Hu 6, Edwin Roger Parra 7, Won-Chul Lee 6, Stephen Swisher 3, Luisa Solis 7, Annikka Weissferdt 8, Cesar Moran 8, Neda Kalhor 8, Jianhua Zhang 6, Paul Scheet 8, Ara A Vaporciyan 3, Boris Sepesi 3, Don L Gibbons 1, John V Heymach 1, Jack J Lee 9, Ignacio I Wistuba 5, P Andrew Futreal 6, Jianjun Zhang 10, Junya Fujimoto 11, Alexandre Reuben 12; 1 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 2 Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 3 Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 4 Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 195 Little Albany St, New Brunswick, NJ 08901, USA. 5 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 6 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 7 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 8 Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA; Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 9 Department of Biostatistics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. 10 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. Electronic address: jzhang20@mdanderson.org. 11 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA. Electronic address: jfujimot@mdanderson.org. 12 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030, USA.
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