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SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans
Mudd PA, et al.
Cell
January 2022
Authors and Affiliates
Philip A Mudd 1, Anastasia A Minervina 2, Mikhail V Pogorelyy 2, Jackson S Turner 3, Wooseob Kim 3, Elizaveta Kalaidina 4, Jan Petersen 5, Aaron J Schmitz 3, Tingting Lei 3, Alem Haile 6, Allison M Kirk 2, Robert C Mettelman 2, Jeremy Chase Crawford 2, Thi H O Nguyen 7, Louise C Rowntree 7, Elisa Rosati 8, Katherine A Richards 9, Andrea J Sant 9, Michael K Klebert 6, Teresa Suessen 10, William D Middleton 10, SJTRC Study Team; Joshua Wolf 11, Sharlene A Teefey 10, Jane A O'Halloran 12, Rachel M Presti 13, Katherine Kedzierska 7, Jamie Rossjohn 14, Paul G Thomas 15, Ali H Ellebedy 16;
1 Department of Emergency Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: pmudd@wustl.edu.
2 Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
3 Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
4 Division of Allergy and Immunology, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
5 Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.
6 Clinical Trials Unit, Washington University School of Medicine, Saint Louis, MO 63110, USA.
7 Department of Microbiology and Immunology, University of Melbourne, at Peter Doherty Institute for Infection and Immunity, Parkville, Victoria 3052, Australia.
8 Institute of Clinical Molecular Biology, Christian-Albrecht University of Kiel, Kiel 24105, Germany.
9 David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
10 Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
11 Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
12 Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
13 Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA; Clinical Trials Unit, Washington University School of Medicine, Saint Louis, MO 63110, USA; Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA.
14 Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia; Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
15 Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: paul.thomas@stjude.org.
16 Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: ellebedy@wustl.edu.
BCMA-Targeted CAR T-cell Therapy plus Radiotherapy for the Treatment of Refractory Myeloma Reveals Potential Synergy
Smith EL, et al.
Cancer Immunology Research
January 2022
Authors and Affiliates
Eric L Smith 1,2, Sham Mailankody 3,2, Mette Staehr 3, Xiuyan Wang 4, Brigitte Senechal 4, Terence J Purdon 3, Anthony F Daniyan 3,5, Mark B Geyer 3,5, Aaron D Goldberg 5, Elena Mead 3,6, Bianca D Santomasso 3,7,8, Jonathan Landa 9, Andreas Rimner 10, Isabelle Riviere 4, Ola Landgren 2, Renier J Brentjens 1,5;
1 Cellular Therapeutics Center, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. smithe3@mskcc.org brentjer@mskcc.org.
2 Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
3 Cellular Therapeutics Center, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
4 Cell Therapy and Cell Engineering Facility, Memorial Sloan Kettering Cancer Center, New York, New York.
5 Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
6 Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
7 Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York.
8 Parker Institute for Cancer Immunotherapy, San Francisco, California.
9 Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
10 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Expansion of Human Papillomavirus-Specific T Cells in Periphery and Cervix in a Therapeutic Vaccine Recipient Whose Cervical High-Grade Squamous Intraepithelial Lesion Regressed
Shibata T, et al.
Frontiers in Immunology
January 2022
Authors and Affiliates
Takeo Shibata 1,2, Sumit Shah 1, Teresa Evans 1, Hannah Coleman 1, Benjamin J Lieblong 1, Horace J Spencer 3, Charles M Quick 1, Toshiyuki Sasagawa 2, Owen W Stephens 4, Erich Peterson 4, Donald Johann Jr 5, Yong-Chen Lu 1, Mayumi Nakagawa 1;
1 Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
2 Department of Obstetrics and Gynecology, Kanazawa Medical University, Uchinada, Japan.
3 Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
4 Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
5 Department of Internal Medicine (Hematology-Oncology Division), University of Arkansas for Medical Sciences, Little Rock, AR, United States.
The T-cell clonal response to SARS-CoV-2 vaccination in inflammatory bowel disease patients is augmented by anti-TNF therapy and often deficient in antibody-responders
Li D, et al.
January 2022
Authors and Affiliates
Dalin Li, Alexander Xu, Emebet Mengesha, Rebecca Elyanow, Rachel M Gittelman, Heidi Chapman, John C Prostko, Edwin C Frias, James L Stewart, Valeriya Pozdnyakova, Philip Debbas, Angela Mujukian, Arash A Horizon, Noah Merin, Sandy Joung, Gregory J Botwin, Kimia Sobhani, Jane C Figueiredo, Susan Cheng, Ian M Kaplan, Dermot P B McGovern, Akil Merchant, Gil Y Melmed, Jonathan Braun;
A Framework to Identify Antigen-Expanded T Cell Receptor Clusters Within Complex Repertoires
Ceglia V, et al.
Frontiers in Immunology
January 2022
Authors and Affiliates
Valentina Ceglia 1,2,3, Erin J Kelley 4, Annalee S Boyle 4, Sandra Zurawski 1,3, Heather L Mead 4, Caroline E Harms 4, Jean-Philippe Blanck 1, Anne-Laure Flamar 1,2,3, Jung Hwa Kirschman 4, Paul Ogongo 5, Joel D Ernst 5, Yves Levy 2,3, Gerard Zurawski 1,3, John A Altin 4;
1 Baylor Institute for Immunology Research, Dallas, TX, United States.
2 Université Paris-Est Créteil, Sciences de la Vie et de la Santé, Créteil, France.
3 Vaccine Research Institute, INSERM, Unité U955, Institut Mondor de Recherche Biomédicale, Créteil, France.
4 Translational Genomics Research Institute, Flagstaff, AZ, United States.
5 Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, San Francisco, CA, United States.
Positive and negative selection shape the human naïve B cell repertoire
Chen JW, et al.
Journal of Clinical Investigation
January 2022
Authors and Affiliates
Jeff W Chen 1, Jean-Nicolas Schickel 1, Nikolaos Tsakiris 1, Joel Sng 1, Florent Arbogast 1, Delphine Bouis 1, Daniele Parisi 1, Ruchi Gera 1, Joshua M Boeckers 1, Fabien R Delmotte 1, Margaret Veselits 2, Catharina Schuetz 3, Eva-Maria Jacobsen 3, Carsten Posovszky 3, Ansgar S Schulz 3, Klaus Schwarz 3, Marcus R Clark 2, Laurence Menard 1, Eric Meffre 1;
1 Department of Immunobiology, Yale University, New Haven, United States of America.
2 Department of Medicine, University of Chicago, Chicago, United States of America.
3 Department of Pediatrics and Adolescent Medicine, Ulm University, Ulm, Germany.
Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy
Mills BN, et al.
Clinical Cancer Research
January 2022
Authors and Affiliates
Bradley N Mills 1, Haoming Qiu 2,3, Michael G Drage 4, Chunmo Chen 4, Jocelyn S Mathew 1, Jesse Garrett-Larsen 1, Jian Ye 1, Taylor P Uccello 5, Joseph D Murphy 5, Brian A Belt 1, Edith M Lord 3,5, Alan W Katz 2,3, David C Linehan 1,3, Scott A Gerber 6,3,5;
1 Department of Surgery, University of Rochester Medical Center, Rochester, New York.
2 Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York.
3 Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York.
4 Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York.
5 Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York.
6 Department of Surgery, University of Rochester Medical Center, Rochester, New York. scott_gerber@urmc.rochester.edu.
Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids
Meng Q, et al.
Journal for ImmunoTherapy of Cancer
January 2022
Authors and Affiliates
Qingda Meng #,1, Shanshan Xie #,1, G Kenneth Gray 2, Mohammad H Dezfulian 3, Weilin Li 1, Ling Huang 1, Dipikaa Akshinthala 1, Elizabeth Ferrer 1, Catherine Conahan 1, Sofia Perea Del Pino 1, Joseph Grossman 1, Stephen J Elledge 3, Manuel Hidalgo 4, Senthil K Muthuswamy 5;
1 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
2 Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
3 Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
4 Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, New York, USA smuthusw@bidmc.harvard.edu mah4006@med.cornell.edu.
5 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA smuthusw@bidmc.harvard.edu mah4006@med.cornell.edu.
# Contributed equally.
Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer
Chen M, et al.
Nature Communications
January 2022
Authors and Affiliates
Ming Chen #,1,2,3,4, Runzhe Chen #,5,6,7, Ying Jin #,8,9,10, Jun Li #,7, Xin Hu #,7, Jiexin Zhang #,11, Junya Fujimoto 12, Shawna M Hubert 6,7, Carl M Gay 6, Bo Zhu 6,7, Yanhua Tian 6,7, Nicholas McGranahan 13, Won-Chul Lee 7, Julie George 14 15, Xiao Hu 8,9,10, Yamei Chen 8,9,10, Meijuan Wu 8,9,10, Carmen Behrens 6, Chi-Wan Chow 12, Hoa H N Pham 16, Junya Fukuoka 16, Jia Wu 17, Edwin Roger Parra 12, Latasha D Little 7, Curtis Gumbs 7, Xingzhi Song 7, Chang-Jiun Wu 7, Lixia Diao 11, Qi Wang 11, Robert Cardnell 6, Jianhua Zhang 7, Jing Wang 11, Xiuning Le 6, Don L Gibbons 6, John V Heymach 6, J Jack Lee 18, William N William Jr 6, Chao Cheng 19, Bonnie Glisson 6, Ignacio Wistuba 12, P Andrew Futreal 7, Roman K Thomas 20,21,22, Alexandre Reuben 23, Lauren A Byers 24, Jianjun Zhang 25,26;
1 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China. chenming@sysucc.org.cn.
2 The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, 310022, China. chenming@sysucc.org.cn.
3 Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China. chenming@sysucc.org.cn.
4 Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, Zhejiang, 310022, China. chenming@sysucc.org.cn.
5 Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510060, China.
6 Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
7 Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
8 The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, 310022, China.
9 Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.
10 Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, Zhejiang, 310022, China.
11 Department of Bioinformatics and Computational Biology, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
12 Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
13 Cancer Research United Kingdom-University College London Lung Cancer Centre of Excellence, London, WC1E6BT, UK.
14 Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, 50931, Germany.
15 Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Cologne, 50937, Cologne, Germany.
16 Department of Pathology, Nagasaki University Graduate school of Biomedical Sciences, Nagasaki, Japan.
17 Department of Image Physics, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
18 Department of Biostatistics, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
19 Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas, 77030, USA.
20 Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, 50931, Germany. roman.thomas@uni-koeln.de.
21 Department of Pathology, Medical Faculty, University Hospital Cologne, Cologne, 50931, Germany. roman.thomas@uni-koeln.de.
22 DKFZ, German Cancer Research Center and German Cancer Consortium (DKTK), Heidelberg, 69115, Germany. roman.thomas@uni-koeln.de.
23 Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA. areuben@mdanderson.org.
24 Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA. lbyers@mdanderson.org.
25 Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA. jzhang20@mdanderson.org.
26 Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA. jzhang20@mdanderson.org.
# Contributed equally.