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Longer term outcomes with single-agent belantamab mafodotin in patients with relapsed or refractory multiple myeloma: 13-month follow-up from the pivotal DREAMM-2 study.

Lonial S, et al.
American Cancer Society Cancer
November 2021
Authors and Affiliates
Sagar Lonial, MD 1; Hans C. Lee, MD2; Ashraf Badros, MD 3; Suzanne Trudel, MD4; Ajay K. Nooka, MD 1; Ajai Chari, MD 5; Al-Ola Abdallah, MD6; Natalie Callander, MD7; Douglas Sborov, MD8; Attaya Suvannasankha, MD9; Katja Weisel, MD10; Peter M. Voorhees, MD11; Lynsey Womersley, MSc12; January Baron, MS13; Trisha Piontek, BSN13; Eric Lewis, MD14; Joanna Opalinska, MD13; Ira Gupta, MD13; and Adam D. Cohen, MD15 1Winship Cancer Institute, Emory University, Atlanta, Georgia; 2Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, Texas; 3Greenebaum Cancer Center, Bone Marrow Transplant Program, University of Maryland at Baltimore, Baltimore, Maryland; 4Princess Margaret Cancer Center, Toronto, Ontario, Canada; 5Icahn School of Medicine at Mount Sinai, New York, New York; 6University of Kansas Cancer Center, Fairway, Kansas; 7Carbone Cancer Center, University of Wisconsin, Madison, Wisconsin; 8Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; 9Indiana University Cancer Center, Indianapolis, Indiana; 10Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center of Hamburg-Eppendorf, Hamburg, Germany; 11Levine Cancer Institute, Atrium Health, Charlotte, North Carolina; 12GlaxoSmithKline, Stockley Park, United Kingdom; 13GlaxoSmithKline, Upper Providence, Pennsylvania; 14GlaxoSmithKline, Research Triangle Park, North Carolina; 15Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania

Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone With Minimal Residual Disease Response-Adapted Therapy in Newly Diagnosed Multiple Myeloma.

Costa LJ, et al.
Journal of Clinical Oncology
November 2021
Authors and Affiliates
Luciano J. Costa, MD, PhD1,2; Saurabh Chhabra, MD3; Eva Medvedova, MD4; Bhagirathbhai R. Dholaria, MD5; Timothy M. Schmidt, MD6; Kelly N. Godby, MD1,2; Rebecca Silbermann, MD4; Binod Dhakal, MD3; Susan Bal, MD1,2; Smith Giri, MD1,2; Anita D’Souza, MD3; Aric Hall, MD6; Pamela Hardwick, RN2; James Omel, MD7; Robert F. Cornell, MD5; Parameswaran Hari, MD3; and Natalie S. Callander, MD6 1Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL 2O’Neal Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, AL 3Division of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 4Oregon Health & Science University, Portland, OR 5Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN 6University of Wisconsin, Madison, WI 7Independent Patient Advocate, Omaha, NE

Characterizing the BCR repertoire during lymphocyte reduction and recovery mediated by cyclophosphamide and granulocyte-macrophage colony-stimulating factor

Li J, et al.
November 2021
Authors and Affiliates
Jun Li 1, Yuehong Li 1, Suhong Sun 2, Liwen Yang 1, Long Ma 1, Bin Shi 1, Rui Ma 1, Xinsheng Yao 3; 1 Department of Immunology, Center of Immunomolecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi City, China. 2 Department of Breast Surgery, The First Affiliated Hospital of ZunYi Medical University, Zunyi City, China. 3 Department of Immunology, Center of Immunomolecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi City, China. Electronic address: immunology01@126.com.

Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8 + T-Cell Responses

He X, et al.
November 2021
Authors and Affiliates
Xuedan He 1, Shiqi Zhou 1, Breandan Quinn 1, Wei-Chiao Huang 1, Dushyant Jahagirdar 2, Michael Vega 3, Joaquin Ortega 2, Mark D Long 4, Fumito Ito 5,6,7, Scott I Abrams 5, Jonathan F Lovell 1; 1 University at Buffalo, State University of New York, Buffalo, NY, 14260, USA. 2 Department of Anatomy and Cell Biology, McGill University Montreal, Quebec, H3A1Y2, Canada. 3 Division of Research and Innovation Partnerships, Northern Illinois University, DeKalb, IL, 60115, USA. 4 Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center (RPCCC), Buffalo, NY, 14263, USA. 5 Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA. 6 Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA. 7 Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.

Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas

Mellors JW, et al.
November 2021
Authors and Affiliates
John W Mellors 1, Shuang Guo 2, Asma Naqvi 1, Leah D Brandt 1, Ling Su 2, Zhonghe Sun 2, Kevin W Joseph 1, Dimiter Demirov 2, Elias K Halvas 1, Donna Butcher 2, Beth Scott 3, Aaron Hamilton 3, Marintha Heil 3, Baktiar Karim 2, Xiaolin Wu 2, Stephen H Hughes 4; 1 Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. 2 Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA. 3 Roche Molecular Diagnostics, Pleasanton, CA, USA. 4 HIV Dynamics and Replication Program, CCR, National Cancer Institute, Frederick, MD, USA.

Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients

Lu X, et al.
November 2021
Authors and Affiliates
Xiuyuan Lu 1, Yuki Hosono 1,2,3, Masamichi Nagae 1,2, Shigenari Ishizuka 1,2, Eri Ishikawa 1,2, Daisuke Motooka 4, Yuki Ozaki 4, Nicolas Sax 5, Yuichi Maeda 3,6, Yasuhiro Kato 3,7, Takayoshi Morita 3,7, Ryo Shinnakasu 8, Takeshi Inoue 8, Taishi Onodera 9, Takayuki Matsumura 9, Masaharu Shinkai 10, Takashi Sato 10, Shota Nakamura 4, Shunsuke Mori 11,12, Teru Kanda 13, Emi E Nakayama 14, Tatsuo Shioda 14,15, Tomohiro Kurosaki 8,15,16, Kiyoshi Takeda 6,15,17, Atsushi Kumanogoh 3,7,15, Hisashi Arase 11,12,15, Hironori Nakagami 18, Kazuo Yamashita 5, Yoshimasa Takahashi 9, Sho Yamasaki 1,2,15,19,20; 1 Laboratory of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Suita, Japan. 2 Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. 3 Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita, Japan. 4 Department of Infection Metagenomics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. 5 KOTAI Biotechnologies, Inc., Suita, Japan. 6 Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Japan. 7 Department of Immunopathology, Immunology Frontier Research Center, Osaka University, Suita, Japan. 8 Laboratory of Lymphocyte Differentiation, Immunology Frontier Research Center, Osaka University, Suita, Japan. 9 Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, Japan. 10 Tokyo Shinagawa Hospital, Tokyo, Japan. 11 Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. 12 Laboratory of Immunochemistry, Immunology Frontier Research Center, Osaka University, Suita, Japan. 13 Division of Microbiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan. 14 Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Japan. 15 Center for Infectious Disease Education and Research, Osaka University, Suita, Japan. 16 Laboratory of Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. 17 Department of Mucosal Immunology, Immunology Frontier Research Center, Osaka University, Suita, Japan. 18 Department of Health Development and Medicine, Graduate School of Medicine, Osaka University, Suita, Japan. 19 Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba, Japan. 20 Division of Molecular Design, Research Center for Systems Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

Distinct tumor-infiltrating lymphocyte landscapes are associated with clinical outcomes in localized non-small cell lung cancer

Federico L, et al.
November 2021
Authors and Affiliates
L Federico 1, D J McGrail 2, S-E Bentebibel 3, C Haymaker 4, A Ravelli 3, M-A Forget 3, T Karpinets 5, P Jiang 6, A Reuben 6, M V Negrao 6, J Li 5, R Khairullah 6, J Zhang 5, A Weissferdt 7, A A Vaporciyan 8, M B Antonoff 8, G Walsh 8, S-Y Lin 2, A Futreal 5, I Wistuba 4, J Roth 8, L A Byers 6, P-O Gaudreau 9, N Uraoka 4, A F Cruz 4, H Dejima 4, R N Lazcano 4, L M Solis 4, E R Parra 4, J J Lee 10, S Swisher 8, T Cascone 6, J V Heymach 6, J Zhang 11, B Sepesi 12, D L Gibbons 13, C Bernatchez 14; 1 Therapeutics Discovery Division. 2 Department of Systems Biology. 3 Department of Melanoma Medical Oncology. 4 Department of Translational Molecular Pathology. 5 Department of Genomic Medicine. 6 Department of Thoracic and Head & Neck Medical Oncology. 7 Department of Pathology. 8 Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center; Houston, Texas, 77030, USA. 9 Department of Oncology, Queens' University and the Canadian Cancer Trials Group; Kingston, Ontario, Canada. 10 Department of Biostatistics. 11 Department of Genomic Medicine; Department of Thoracic and Head & Neck Medical Oncology. Electronic address: jzhang20@mdanderson.org. 12 Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center; Houston, Texas, 77030, USA. Electronic address: bsepesi@mdanderson.org. 13 Department of Thoracic and Head & Neck Medical Oncology; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center; Houston, Texas, 77030, USA. Electronic address: dlgibbon@mdanderson.org. 14 Department of Melanoma Medical Oncology. Electronic address: cbernatchez@mdanderson.org.

A Phase I, Open-Label, Dose-Escalation Study of the OX40 Agonist Ivuxolimab in Patients With Locally Advanced or Metastatic Cancers

Diad A, et al.
November 2021
Authors and Affiliates
Adi Diab 1, Omid Hamid 2, John A Thompson 3, Willeke Ros 4, Ferry A L M Eskens 5, Toshihiko Doi 6, Siwen Hu-Lieskovan 7, Samuel J Klempner 8, Bishu Ganguly 9, Catherine Fleener 10, Xiao Wang 11, Tenshang Jo 11, Ken Liao 12, Shahram Salek-Ardakani 13, Carrie Turich Taylor 9, Jeffrey Chou 14, Anthony B El-Khoueiry 15; 1 Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center adiab@mdanderson.org. 2 Research, The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate. 3 Medicine/Medical Oncology, University of Washington. 4 Netherlands Cancer Institute. 5 Department of Medical Oncology, Erasmus MC Cancer Institute. 6 Department of Experimental Therapeutics, National Cancer Center Hospital East. 7 David Geffen School of Medicine at UCLA. 8 Oncology, Massachusetts General Hospital. 9 Pfizer Inc. 10 Translational Medicine, Xencor Inc. 11 Pfizer (United States). 12 Clinical Pharmacology, Pfizer (United States). 13 Cancer Immunology Discovery, Pfizer (United States). 14 WRDM, Pfizer (United States). 15 Division of Medical Oncology, USC Norris Comprehensive Cancer Center.

An allogeneic multiple myeloma GM-CSF-secreting vaccine with lenalidomide induces long-term immunity and durable clinical responses in patients in near complete remission

Biavat L, et al.
November 2021
Authors and Affiliates
Luca Biavati 1, Carol Ann Huff 2, Anna Ferguson 3, Amy Sidorski 4, M Amanda Stevens 5, Lakshmi Rudraraju 6, Cristina Zucchinetti 1, Syed Abbas Ali 2, Philip Imus 1, Christian B Gocke 2, Rachel M Gittelman 7, Sarah Johnson 8, Catherine Sanders 9, Marissa Vignali 10, Anita Gandhi 11, Xiaobu Ye 3, Kimberly A Noonan 6, Ivan Borrello 12; 1 Oncology, Johns Hopkins Medicine. 2 Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine. 3 Oncology, Johns Hopkins University. 4 Johns Hopkins University School of Medicine. 5 Hematologic Malignancies, Johns Hopkins Medicine. 6 Johns Hopkins Medicine. 7 Adaptive Biotechnologies (United States). 8 Computational Biology, Adaptive Biotechnologies (United States). 9 Business Development, Adaptive Biotechnologies (United States). 10 Adaptive Biotechnology. 11 Bristol-Myers Squibb (United States). 12 Oncology, Johns Hopkins University School of Medicine iborrell@jhmi.edu.

T cell receptor repertoires as potential diagnostic markers for patients with COVID-19

Hou X, et al.
November 2021
Authors and Affiliates
Xianliang Hou 1, Wentao Fan 2, Guangyu Wang 3, Xiaoyan Chen 4, Chune Mo 1, Yongsi Wang 2, Weiwei Gong 1, Xuyan Wen 5, Hui Chen 2, Dan He 2, Lijun Mo 6, Shaofeng Jiang 7, Minglin Ou 8, Haonan Guo 9, Hongbo Liu 10; 1 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. 2 Guangzhou Huayin Health Medical Group Co., Ltd (Guangzhou, China). 3 College of Laboratory Medicine, Guilin Medical University, Guilin, 541199, China. 4 Department of State owned Assets Management, Affiliated Hospital of Guilin Medical University, Guilin, 541001, China. 5 Department of pathology, Affiliated Hospital of Guilin Medical University, Guilin, 541001. 6 Clinical Laboratory, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199. 7 Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, Guangxi, 541199, China. 8 Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. Electronic address: minglinou@glmc.edu.cn. 9 Department of Clinical Laboratory, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, 541001, China. Electronic address: guohaonan@glmc.edu.cn. 10 Department of Laboratory Medicine, the Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China. Electronic address: hbliu@glmc.edu.cn.