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CD8 + T cell immunity blocks the metastasis of carcinogen-exposed breast cancer

Li K, et al.
Science Advances
June 2021
Authors and Affiliates
Kaiwen Li 1 2, Tiancheng Li 1, Zhaoyi Feng 1, Mei Huang 1, Lei Wei 3, Zhiyu Yan 1, Mark Long 3, Qiang Hu 3, Jianmin Wang 3, Song Liu 3, Dennis C Sgroi 4, Shadmehr Demehri 5; 1 Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. 2 Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. 3 Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA. 4 Molecular Pathology Unit, Department of Pathology, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. 5 Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. sdemehri1@mgh.harvard.edu.

Biophysicochemical motifs in T cell receptor sequences as a potential biomarker for high-grade serous ovarian carcinoma

Ostmeyer J, et al.
PLOS ONE
June 2021
Authors and Affiliates
Jared Ostmeyer 1, Elena Lucas 2, Scott Christley 1, Jayanthi Lea 3, Nancy Monson 4, Jasmin Tiro 1, Lindsay G Cowell 5; 1 Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, United States of America. 2 Department of Pathology, UT Southwestern Medical Center, Dallas, TX, United States of America. 3 Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, TX, United States of America. 4 Department of Neurology and Neurotherapeutics, Department of Immunology, UT Southwestern Medical Center, Dallas, TX, United States of America. 5 Department of Population and Data Sciences, Department of Immunology, UT Southwestern Medical Center, Dallas, TX, United States of America.

T Cell Receptor Repertoires Acquired via Routine Pap Testing May Help Refine Cervical Cancer and Precancer Risk Estimates

Christley S, et al.
Frontiers in Immunology
June 2021
Authors and Affiliates
Scott Christley 1, Jared Ostmeyer 1, Lisa Quirk 1, Wei Zhang 2, Bradley Sirak 3, Anna R Giuliano 3, Song Zhang 1, Nancy Monson 2, Jasmin Tiro 1, Elena Lucas 4,5, Lindsay G Cowell 1,2; 1 Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, United States. 2 Department of Neurology and Neurotherapeutics, Department of Immunology, UT Southwestern Medical Center, Dallas, TX, United States. 3 Center for Immunization and Infection Research, Moffitt Cancer Center, Tampa, FL, United States. 4 Department of Pathology, UT Southwestern Medical Center, Dallas, TX, United States. 5 Department of Pathology, Parkland Health and Hospital System, Dallas, TX, United States

Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4+ T cell repertoire

Brown IK, et al.
PLOS Pathogens
June 2021
Authors and Affiliates
Ivy K Brown 1, Nathan Dyjack 2, Mindy M Miller 1, Harsha Krovi 3, Cydney Rios 2, Rachel Woolaver 3, Laura Harmacek 2, Ting-Hui Tu 2, Brian P O'Connor 2,3,4, Thomas Danhorn 2, Brian Vestal 2, Laurent Gapin 3, Clemencia Pinilla 5, Max A Seibold 2,4,6, James Scott-Browne 1,2,3, Radleigh G Santos 7, R Lee Reinhardt 1,3; 1 Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado, United States of America. 2 Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, United States of America. 3 Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America. 4 Department of Pediatrics, National Jewish Health, Denver, Colorado, United States of America. 5 Florida International University, Port Saint Lucie, Florida, United States of America. 6 Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America. 7 Department of Mathematics, Nova Southeastern University, Fort Lauderdale, Florida, United States of America.

B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

Ruffin AT, et al.
Nature Communications
June 2021
Authors and Affiliates
Ayana T Ruffin 1,2,3,4, Anthony R Cillo 1,2,4, Tracy Tabib 5, Angen Liu 6, Sayali Onkar 1,2,3,4, Sheryl R Kunning 1,2,4, Caleb Lampenfeld 1,2,4, Huda I Atiya 4,7, Irina Abecassis 1,2,4, Cornelius H L Kürten 8, Zengbiao Qi 5, Ryan Soose 6, Umamaheswar Duvvuri 4,5, Seungwon Kim 6, Steffi Oesterrich 4,9,10, Robert Lafyatis 5,6, Lan G Coffman 4,7, Robert L Ferris 1,2,4,6,11, Dario A A Vignali 1,2,4,11, Tullia C Bruno 12,13,14,15; 1 Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. 2 Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA. 3 Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 4 Hillman Cancer Center, Pittsburgh, PA, USA. 5 Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. 6 Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA. 7 Division of Hematology and Oncology, Department of Medicine, Hillman Cancer Center, Pittsburgh, PA, USA. 8 Department of Otorhinolaryngology, University Duisburg-Essen, Essen, Germany. 9 Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA. 10 Women's Cancer Research Center, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA. 11 Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. 12 Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. tbruno@pitt.edu. 13 Tumor Microenvironment Center, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA. tbruno@pitt.edu. 14 Hillman Cancer Center, Pittsburgh, PA, USA. tbruno@pitt.edu. 15 Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. tbruno@pitt.edu.

Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans

Alter G, et al.
Nature
June 2021
Authors and Affiliates
Galit Alter 1,2,9, Jingyou Yu 1,9, Jinyan Liu 1,9, Abishek Chandrashekar 1,9, Erica N. Borducchi 1,9, Lisa H. Tostanoski 1,9, Katherine McMahan 1,9, Catherine Jacob-Dolan 1,3,9, David R. Martinez 4, Aiquan Chang 1,3, Tochi Anioke 1, Michelle Lifton 1, Joseph Nkolola 1, Kathryn E. Stephenson 1, Caroline Atyeo 2,3, Sally Shin 2, Paul Fields 5, Ian Kaplan 5, Harlan Robins 5, Fatima Amanat 6, Florian Krammer 6, Ralph S. Baric 4, Mathieu Le Gars 7, Jerald Sadoff 7, Anne Marit de Groot 7, Dirk Heerwegh 8, Frank Struyf 8, Macaya Douoguih 7, Johan van Hoof 7, Hanneke Schuitemaker 7 and Dan H. Barouch 1,2,3; 1 Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA. 2 Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. 3 Harvard Medical School,Boston, MA, USA. 4 University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 5 Adaptive Biotechnologies, Seattle, WA, USA. 6 Icahn School of Medicine at Mount Sinai, New York, NY, USA. 7 Janssen Vaccines & Prevention, Leiden, The Netherlands. 8 Janssen Research & Development, Beerse, Belgium. 9 These authors contributed equally: Galit Alter, Jingyou Yu, Jinyan Liu, Abishek Chandrashekar, Erica N. Borducchi, Lisa H. Tostanoski, Katherine McMahan, Catherine Jacob-Dolan.

Shared transcriptional profiles of atypical B cells suggest common drivers of expansion and function in malaria, HIV, and autoimmunity

Holla P, et al.
Science Advances
June 2021
Authors and Affiliates
Prasida Holla 1, Brian Dizon 2, Abhijit A Ambegaonkar 1, Noga Rogel 3, Ella Goldschmidt 3, Arun K Boddapati 4, Haewon Sohn 1, Dan Sturdevant 5, James W Austin 6, Lela Kardava 6, Li Yuesheng 7, Poching Liu 7, Susan Moir 6, Susan K Pierce 8, Asaf Madi 9; 1 Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. 2 National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. 3 Department of Pathology, Sackler School of Medicine, Tel Aviv University, Israel. 4 NIAID Collaborative Bioinformatics Resource, National Institutes of Health, Bethesda, MD, USA. 5 RML Genomics Unit, Research Technologies Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. 6 Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 7National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. 8Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA. asafmadi@gmail.com spierce@nih.gov. 9Department of Pathology, Sackler School of Medicine, Tel Aviv University, Israel. asafmadi@gmail.com spierce@nih.gov.

Identification of antigen-specific TCR sequences based on biological and statistical enrichment in unselected subjects

Smith NP, et al.
JCI Insight
June 2021
Authors and Affiliates
Neal P Smith 1, Bert Ruiter 1, Yamini V Virkud 1, Ang A Tu 2, Brinda Monian 2, James J Moon 1, J Christopher Love 2, Wayne G Shreffler 1; 1 Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, United States of America. 2 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, United States of America.

Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2

Low JS, et al.
Science
June 2021
Authors and Affiliates
Jun Siong Low 1, Daniela Vaqueirinho 1, Federico Mele 1, Mathilde Foglierini 1, Josipa Jerak 1, Michela Perotti 1, David Jarrossay 1, Sandra Jovic 1, Laurent Perez 1, Rosalia Cacciatore 2, Tatiana Terrot 3, Alessandra Franzetti Pellanda 4, Maira Biggiogero 4, Christian Garzoni 4, Paolo Ferrari 5,6,7, Alessandro Ceschi 3,5,8,9, Antonio Lanzavecchia 10, Federica Sallusto 11,12, Antonino Cassotta 11; 1 Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland. 2 Laboratory of Immunogenetics, Department of Transfusion Medicine and Immuno-Hematology, Fondazione I.R.C.C.S. Policlinico S. Matteo, 27100 Pavia, Italy. 3 Clinical Trial Unit, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland. 4 Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, 6900 Lugano, Switzerland. 5 Faculty of Biomedical Sciences, Università della Svizzera italiana, 6900 Lugano, Switzerland. 6 Department of Internal Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland. 7 Prince of Wales Hospital Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia. 8 Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland. 9 Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, 8091 Zurich, Switzerland. 10 National Institute of Molecular Genetics, 20122 Milano, Italy. 11 Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland. federica.sallusto@irb.usi.ch antonino.cassotta@irb.usi.ch. 12 Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland.
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