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BRAF and MEK inhibition in melanoma patients enables reprogramming of tumor infiltrating lymphocytes

Peiffer L., et al.
December 2020
Authors and Affiliates
Lukas Peiffer 1,2, Farnoush Farahpour 3, Ashwin Sriram 1 2, Ivelina Spassova 1, Daniel Hoffmann 3, Linda Kubat 1, Patrizia Stoitzner 4, Thilo Gambichler 5, Antje Sucker 6, Selma Ugurel 6, Dirk Schadendorf 6, Jürgen C Becker 7,8,9; 1 Deutsches Konsortium Für Translationale Krebsforschung (DKTK), Partner Site Essen, Translational Skin Cancer Research, University of Duisburg-Essen, Universitätsstr. 1, 45141, Essen, Germany. 2 Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany. 3 Bioinformatics and Computational Biophysics, University Duisburg-Essen, Essen, Germany. 4 Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria. 5 Department of Dermatology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany. 6 Department of Dermatology, University Hospital of Essen, Essen, Germany. 7 Deutsches Konsortium Für Translationale Krebsforschung (DKTK), Partner Site Essen, Translational Skin Cancer Research, University of Duisburg-Essen, Universitätsstr. 1, 45141, Essen, Germany. j.becker@dkfz.de. 8 Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany. j.becker@dkfz.de. 9 Department of Dermatology, University Hospital of Essen, Essen, Germany. j.becker@dkfz.de.

Diagnostic differentiation of Zika and dengue virus exposure by analyzing T cell receptor sequences from peripheral blood of infected HLA-A2 transgenic mice

Hassert M., et al.
December 2020
Authors and Affiliates
Mariah Hassert 1, Kyle J Wolf 1, Ahmad Rajeh 2, Courtney Shiebout 2, Stella G Hoft 1, Tae-Hyuk Ahn 2 3, Richard J DiPaolo 1, James D Brien 1, Amelia K Pinto 1; 1 Department of Molecular Microbiology and Immunology, Saint Louis University- School of Medicine, Saint Louis, Missouri, United States of America. 2 Program in Bioinformatics and Computational Biology, Saint Louis University, Saint Louis, Missouri, United States of America. 3 Department of Computer Science, Saint Louis University, Saint Louis, Missouri, United States of America.

Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+ T Lymphocyte Signature

Kelkka T., et al.
December 2020
Authors and Affiliates
Tiina Kelkka 1,2,3,4, Paula Savola 1,2,3,4, Dipabarna Bhattacharya 1,2,3,4, Jani Huuhtanen 1,2,3,4, Tapio Lönnberg 5, Matti Kankainen 1,2,4, Kirsi Paalanen 6, Mikko Tyster 1,2,3,4, Maija Lepistö 7, Pekka Ellonen 7, Johannes Smolander 5, Samuli Eldfors 7, Bhagwan Yadav 1,2,3,4, Sofia Khan 5, Riitta Koivuniemi 8, Christopher Sjöwall 9, Laura L. Elo 5,10, Harri Lähdesmäki 11, Yuka Maeda 12, Hiroyashi Nishikawa 12, Marjatta Leirisalo-Repo 8, Tuulikki Sokka-Isler 6,13 and Satu Mustjoki 1,2,3,4; 1 Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland 2 Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland 3 Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland 4 Translational Immunology Research Program, University of Helsinki, Helsinki, Finland 5 Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland 6 Rheumatology, Jyväskylä Central Hospital, Jyväskylä, Finland 7 Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland 8 Rheumatology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland 9 Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden 10 Institute of Biomedicine, University of Turku, Turku, Finland 11 Department of Computer Science, Aalto University School of Science, Espoo, Finland 12 Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo, Japan 13 University of Eastern Finland, Faculty of Health Sciences, Kuopio, Finland

Integrative Tumor and Immune Cell Multi-omic Analyses Predict Response to Immune Checkpoint Blockade in Melanoma

Anagnostou V., et al.
December 2020
Authors and Affiliates
Valsamo Anagnostou 1,2, Daniel C Bruhm 1, Noushin Niknafs 1, James R White 1, Xiaoshan M Shao 1, John William Sidhom 1,2, Julie Stein 2,3, Hua-Ling Tsai 1, Hao Wang 1, Zineb Belcaid 1,2, Joseph Murray 1,2, Archana Balan 1, Leonardo Ferreira 1, Petra Ross-Macdonald 4, Megan Wind-Rotolo 4, Alexander S Baras 2,3, Janis Taube 2,3, Rachel Karchin 1, Robert B Scharpf 1, Catherine Grasso 5,6, Antoni Ribas 5,7, Drew M Pardoll 1,2, Suzanne L Topalian 1,2,8, Victor E Velculescu 1,2,3; 1 The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. 2 The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. 3 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. 4 Bristol-Myers Squibb, Princeton, NJ 08540, USA. 5 Jonsson Comprehensive Cancer Center at the University of California, Los Angeles (UCLA), Los Angeles, CA, USA. 6 Cedars-Sinai Medical Center, Los Angeles, CA, USA. 7 Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. 8 Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Public and private human T-cell clones respond differentially to HCMV antigen when boosted by CD3 copotentiation

Becher LRE., et al.
December 2020
Authors and Affiliates
Laura R E Becher 1,2, Wendy K Nevala 2, Shari Lee Sutor 2, Megan Abergel 3,4,5, Michele M Hoffmann 1, Christopher A Parks 1, Larry R Pease 1, Adam G Schrum 3,4,5, Svetomir N Markovic 2, Diana Gil 3,4,5; 1Department of Immunology, Mayo Clinic Graduate School of Biomedical Sciences, and. 2Department of Oncology, Mayo Clinic, Rochester, MN; and. 3Department of Surgery, School of Medicine. 4Department of Molecular Microbiology & Immunology, School of Medicine, and. 5Department of Bioengineering, College of Engineering, University of Missouri, Columbia, MO.

The T Cell Receptor Repertoire in Neuropsychiatric Systemic Lupus Erythematosus

Moore E., et al.
December 2020
Authors and Affiliates
Erica Moore 1, Michelle W Huang 1, Shweta Jain 2, Samantha A Chalmers 1, Fernando Macian 3, Chaim Putterman 1,4,5,6; 1 Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, United States. 2 Early Discovery and Fundamental Research, Hansoh Bio, Rockville, MD, United States. 3 Department of Pathology, Albert Einstein College of Medicine, New York, NY, United States. 4 Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, United States. 5 Bar-Ilan University Azrieli Faculty of Medicine, Ramat Gan, Israel. 6 Galilee Medical Center, Nahariya, Israel.

Discovery of Marburg virus neutralizing antibodies from virus-naïve human antibody repertoires using large-scale structural predictions

Bozhanova NG., et al.
November 2020
Authors and Affiliates
Nina G Bozhanova 1,2, Amandeep K Sangha 1,2, Alexander M Sevy 2,3, Pavlo Gilchuk 3, Kai Huang , 5, Rachel S Nargi 3, Joseph X Reidy 3, Andrew Trivette 3, Robert H Carnahan 3,6, Alexander Bukreyev 4,5,7, James E Crowe Jr 3,6,8, Jens Meiler 9,2,10; 1 Department of Chemistry, Vanderbilt University, Nashville, TN 37235. 2 Center for Structural Biology, Vanderbilt University, Nashville, TN 37235. 3 Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232. 4 Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555. 5 Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550. 6 Department of Pediatrics, Vanderbilt University Medical Center, Nashville TN 37232. 7 Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555. 8 Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232. 9 Department of Chemistry, Vanderbilt University, Nashville, TN 37235; jens@meilerlab.org. 10 Institute for Drug Discovery, Leipzig University Medical School, Leipzig, SAC 04103, Germany.

Long-term skin-resident memory T cells proliferate in situ and are involved in human graft-versus-host disease

Strobl J., et al.
November 2020
Authors and Affiliates
Johanna Strobl 1, Ram Vinay Pandey 1, Thomas Krausgruber 2, Nadine Bayer 1, Lisa Kleissl 1,3, Bärbel Reininger 1, Pablo Vieyra-Garcia 4, Peter Wolf 4, Maaia-Margo Jentus 1, Margit Mitterbauer 5, Philipp Wohlfarth 5, Werner Rabitsch 5, Georg Stingl 1, Christoph Bock 2,3,6, Georg Stary 7,2,3; 1 Department of Dermatology, Medical University of Vienna, 1090 Vienna, Austria. 2 CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria. 3 Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, 1090 Vienna, Austria. 4 Department of Dermatology and Venereology, Medical University of Graz, 8036 Graz, Austria. 5 Department of Internal Medicine I, Hematopoietic Stem Cell Transplantation Unit, Medical University of Vienna, 1090 Vienna, Austria. 6 Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria. 7 Department of Dermatology, Medical University of Vienna, 1090 Vienna, Austria. georg.stary@meduniwien.ac.at.

Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis

Jiang R., et al.
November 2020
Authors and Affiliates
Ruoyi Jiang 1, Kenneth B Hoehn 2, Casey S Lee 3, Minh C Pham 1, Robert J Homer 2,4, Frank C Detterbeck 5, Inmaculada Aban 6, Leslie Jacobson 7, Angela Vincent 7, Richard J Nowak 3, Henry J Kaminski 8, Steven H Kleinstein 9,2,10, Kevin C O'Connor 9,3; 1 Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511. 2 Department of Pathology, Yale University School of Medicine, New Haven, CT 06511. 3 Department of Neurology, Yale University School of Medicine, New Haven, CT 06511. 4 Pathology & Laboratory Medicine Service, VA CT Health Care System, West Haven, CT 06516. 5 Department of Surgery, Yale University School of Medicine, New Haven, CT 06511. 6 Department of Biostatistics, University of Alabama, Birmingham, AL 35294. 7 Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX1 2JD Oxford, United Kingdom. 8 Department of Neurology, The George Washington University, Washington, DC 20052. 9 Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511; steven.kleinstein@yale.edu kevin.oconnor@yale.edu. 10 Interdepartmental Program in Computational Biology & Bioinformatics, Yale University, New Haven, CT 06511

Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM

Meurer T., et al.
November 2020
Authors and Affiliates
Thuja Meurer 1, Pietro Crivello 2, Maximilian Frederik Metzing 1, Michel Kester 3, Dominik A Megger 4, Weiqiang Chen 4, P A van Veelen 5, Peter van Balen 3, Astrid Westendorf 6, Georg Homa 1, Sophia E Layer 1, Amin T Turki 1, Marieke Griffioen 3, Peter A Horn 1, Barbara Sitek 7, Dietrich W Beelen 8, J H Frederik Falkenburg 9, Esteban Arrieta-Bolaños 10, Katharina Fleischhauer 10; 1 University Hospital Essen, Essen, Germany. 2 Essen University Hospital, Essen, Germany. 3 Leiden University Medical Center, Leiden, Netherlands. 4 Medical Proteome Center, Ruhr University Bochum, Bochum, Germany. 5 Centre for Medical Systems Biology, Leiden University Medical Center, Leiden, Netherlands. 6 University of Duisburg-Essen, University Hospital Essen, Essen, Germany. 7 Ruhr-University Bochum. 8 University Hospital of Essen, Essen, Germany. 9 Leiden University of Medical Center, Leiden, Netherlands. 10 German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Germany.