A Circulating Reservoir of Pathogenic-Like CD4+ T Cells Shares a Genetic and Phenotypic Signature with the Inflamed Synovial Micro-Environment

Spreafico R1,2, Rossetti M1,2, van Loosdregt J1, Wallace CA3, Massa M4, Magni-Manzoni S5, Gattorno M6, Martini A6, Lovell DJ7,8, Albani S1,2 Translational Research Unit, Sanford-Burnham Medical Research Institute, San Diego, CA1; Singhealth Translational Immuology and Inflammation Centre, Singhealth and Duke-NUS Graduate Medical School, Singapore, Singapore2; Seattle Children's Hospital and Research Institute, Seattle, WA3; Lab Biotecnologie, Fondazione IRCCS Piloclinico San Matteo, Pavia, Italy4; Pediatric Rheumatology Unit, IRCCS Ospedale Pediatrico Bambino Gesu, Rome, Italy5; Second Pediatrics Division, University of Genoa and G Gaslini Institute, Genova, Italy6; Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH7; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH8