BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes

Zachary A Cooper, 1 , 2 Dennie T Frederick, 3 Vikram R Juneja, 4 , 5 Ryan J Sullivan, 6 , 7 Donald P Lawrence, 6 ,7 Adriano Piris, 7 , 8 Arlene H Sharpe, 4 David E Fisher, 7 , 9 Keith T Flaherty, 6 , 7 and Jennifer A Wargo 1 , 2 1Department of Surgical Oncology; University of Texas MD Anderson Cancer Center; Houston, TX USA 2Department of Genomic Medicine; University of Texas MD Anderson Cancer Center; Houston, TX USA 3Division of Surgical Oncology; Massachusetts General Hospital; Boston, MA USA 4Department of Microbiology and Immunobiology; Harvard Medical School; Boston, MA USA 5Division of Health Sciences and Technology; Massachusetts Institute of Technology; Cambridge, MA USA 6Division of Medical Oncology; Massachusetts General Hospital; Boston, MA USA 7Harvard Medical School; Boston, MA USA 8Division of Dermatophathology; Massachusetts General Hospital; Boston, MA USA 9Division of Dermatology; Massachusetts General Hospital; Boston, MA USA