Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma

Dheilly E1, Battistello E2, Katanayeva N1, Sungalee S1, Michaux J3, Duns G4, Wehrle S5, Sordet-Dessimoz J6, Mina M7, Racle J8, Farinha P4, Coukos G3, Gfeller D8, Mottok A9, Kridel R10, Correia BE11, Steidl C4, Bassani-Sternberg M3, Ciriello G7, Zoete V12, Oricchio E13.; 1 Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, 1015 Switzerland; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland. 2 Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, 1015 Switzerland; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland; Department of Computational Biology, University of Lausanne, 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland. 3 Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland; Ludwig Institute for Cancer Research and Department of Oncology, University of Lausanne, Lausanne, Switzerland; Department of Oncology, University Hospital of Lausanne, Lausanne, Switzerland. 4 Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, BC, Canada. 5 Institute of Bioengineering, EPFL, 1015 Lausanne, Switzerland. 6 Histology Core Facility, EPFL, 1015 Lausanne, Switzerland. 7 Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland; Department of Computational Biology, University of Lausanne, 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland. 8 Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland; Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland; Ludwig Institute for Cancer Research and Department of Oncology, University of Lausanne, Lausanne, Switzerland; Department of Oncology, University Hospital of Lausanne, Lausanne, Switzerland. 9 Institute of Human Genetics, Ulm University and Ulm University Medical Center, Germany. 10 Princess Margaret Cancer Center, Toronto, Canada. 11 Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland; Institute of Bioengineering, EPFL, 1015 Lausanne, Switzerland. 12 Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland; Swiss Institute of Bioinformatics (SIB), Lausanne 1015, Switzerland; Ludwig Institute for Cancer Research and Department of Oncology, University of Lausanne, Lausanne, Switzerland; Molecular Modeling Group, SIB, Lausanne, Switzerland. 13 Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, EPFL, Lausanne, 1015 Switzerland; Swiss Cancer Center Leman (SCCL), Lausanne, 1015 Switzerland. Electronic address: elisa.oricchio@epfl.ch.