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Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities

Subudhia et al.
Papers
Proceedings of the National Academy of Sciences
October 2016
Authors and Affiliates
Sumit K. Subudhia,1, Ana Aparicioa,1, Jianjun Gaoa, Amado J. Zuritaa, John C. Araujoa, Christopher J. Logothetisa, Salahaldin A. Tahira, Brinda R. Korivib, Rebecca S. Slackc, Luis Venced, Ryan O. Emersone, Erik Yuskoe, Marissa Vignalie, Harlan S. Robinse,f, Jingjing Sung, James P. Allisond,g,2, and Padmanee Sharmaa,d,g,2 aDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; bDepartment of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; cDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; dImmunotherapy Platform, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; eAdaptive Biotechnologies, Seattle, WA 98102; fFred Hutchinson Cancer Research Center, Seattle, WA 98102; and gDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030