Concurrent PD-1 Blockade Negates the Effects of OX40 Agonist Antibody in Combination Immunotherapy through Inducing T-cell Apoptosis

Rajeev K. Shrimali1, Shamim Ahmad1, Vivek Verma1, Peng Zeng1, Sudha Ananth1, Pankaj Gaur1, Rachel M. Gittelman2, Erik Yusko2, Catherine Sanders2, Harlan Robins2,3, Scott A. Hammond4, John E. Janik1, Mikayel Mkrtichyan1, Seema Gupta1, and Samir N. Khleif1 1Georgia Cancer Center, Augusta University, Augusta, Georgia. 2Adaptive Biotechnologies, Seattle, Washington. 3Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington. 4MedImmune LLC, Gaithersburg, Maryland.