High-throughput sequencing of the T cell receptor b gene identifies aggressive early-stage mycosis fungoides

Adele de Masson,1 John T. O’Malley,1 Christopher P. Elco,1 Sarah S. Garcia,1 Sherrie J. Divito,1 Elizabeth L. Lowry,1 Marianne Tawa,1 David C. Fisher,2 Phillip M. Devlin,3 Jessica E. Teague,1 Nicole R. Leboeuf,1 Ilan R. Kirsch,4 Harlan Robins,4 Rachael A. Clark,1 Thomas S. Kupper1 1Department of Dermatology, Brigham and Women’s Hospital, and the Center for Cutaneous Oncology, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, Boston, MA 02115, USA. 2Center for Hematologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. 3Department of Radiation Oncology, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, Boston, MA 02115, USA. 4Adaptive Biotechnologies, Seattle, WA 98102, USA.