Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens

Erin W. Meermeier1, Bruno F. Laugel2, Andrew K. Sewell2, Alexandra J. Corbett3, Jamie Rossjohn2,4,5, James McCluskey3, Melanie J. Harriff6,7, Tamera Franks7, Marielle C. Gold1,6,7 & David M. Lewinsohn1,6,7 1 Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239 USA. 2 Institute of Infection and Immunity, HenryWellcome Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, UK. 3 Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia. 4 Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia. 5 ARC Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia. 6 Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA. 7 Department of Research, VA Portland Health Care Center, Portland, Oregon 97239, USA