Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression

Christian Mueller1, Jeffrey D. Chulay2, Bruce C. Trapnell3, Margaret Humphries1, Brenna Carey3, Robert A. Sandhaus4, Noel G. McElvaney5, Louis Messina1, Qiushi Tang1, Farshid N. Rouhani6, Martha Campbell-Thompson6, Ann Dongtao Fu6, Anthony Yachnis6, David R. Knop2, Guo-jie Ye2, Mark Brantly6, Roberto Calcedo7, Suryanarayan Somanathan7, Lee P. Richman8, Robert H. Vonderheide8, Maigan A. Hulme6, Todd M. Brusko6, James M. Wilson7, and Terence R. Flotte1, 8 1University of Massachusetts Medical School, Worcester, Massachusetts, USA. 2Applied Genetic Technologies Corp., Alachua, Florida, USA. 3Cincinnati Children’s Hospital, Cincinnati, Ohio, USA. 4National Jewish Health, Denver, Colorado, USA. 5Beaumont Hospital, Dublin, Ireland. 6University of Florida College of Medicine, Gainesville, Florida, USA. 7Gene Therapy Program and 8Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.