Ibrutinib Therapy Increases T Cell Repertoire Diversity in Patients with Chronic Lymphocytic Leukemia

Qingsong Yin,*,†,1 Mariela Sivina,*,1 Harlan Robins,‡,x Erik Yusko,‡ Marissa Vignali,‡ Susan O’Brien,* Michael J. Keating,* Alessandra Ferrajoli,* Zeev Estrov,* Nitin Jain,* William G. Wierda,* and Jan A. Burger* *Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77230; †Department of Leukemia, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Henan Institute of Hematology, Zhengzhou, Henan 450009, China; ‡Adaptive Biotechnologies, Seattle, WA 98102; and xFred Hutchinson Cancer Research Center, Seattle, WA 98109