Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Giovanni Germano1,2, Simona Lamba1, Giuseppe Rospo1, Ludovic Barault1,2, Alessandro Magrì1,2, Federica Maione1, Mariangela Russo1,2, Giovanni Crisafulli1,2, Alice Bartolini1, Giulia Lerda1,2, Giulia Siravegna1,2, Benedetta Mussolin1, Roberta Frapolli3, Monica Montone1, Federica Morano4, Filippo de Braud4,5, Nabil Amirouchene-Angelozzi1,6, Silvia Marsoni1, Maurizio D’Incalci3, Armando Orlandi7, Enrico Giraudo1,8, Andrea Sartore-Bianchi9, Salvatore Siena5,9, Filippo Pietrantonio4, Federica Di Nicolantonio1,2 & Alberto Bardelli1,2 1Candiolo Cancer Institute – FPO, IRCCS, Candiolo 10060, Turin, Italy. 2University of Turin, Department of Oncology, Candiolo 10060, Turin, Italy. 3IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan 20156, Italy. 4Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy. 5Department of Oncology and Hemat-Oncology Università degli Studi di Milano, Milan 20122, Italy. 6FIRC Institute of Molecular Oncology (IFOM), Milan 20139, Italy. 7Policlinico Universitario A. Gemelli, Roma 00168, Italy. 8University of Torino, Department of Science and Drug Technology, Turin 10125, Italy. 9Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan 20142, Italy.