Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses

Yonit Lavin,1,2,3 Soma Kobayashi,1,2,3 Andrew Leader,1,2,3 El-ad David Amir,2,3,9 Naama Elefant,10 Camille Bigenwald,1,2,3 Romain Remark,1,2,3 Robert Sweeney,6,7 Christian D. Becker,4 Jacob H. Levine,11 Klaus Meinhof,4 Andrew Chow,1,2,3 Seunghee Kim-Shulze,2,3,9 Andrea Wolf,6 Chiara Medaglia,10 Hanjie Li,10 Julie A. Rytlewski,12 Ryan O. Emerson,12 Alexander Solovyov,1,3,5,8 Benjamin D. Greenbaum,1,3,5,8 Catherine Sanders,12 Marissa Vignali,12 Mary Beth Beasley,8 Raja Flores,6 Sacha Gnjatic,2,3,5,9 Dana Pe’er,11 Adeeb Rahman,2,3,7,9 Ido Amit,10 and Miriam Merad1,2,3,9 1Department of Oncological Sciences 2The Precision Immunology Institute 3Tisch Cancer Institute 4Division of Pulmonology 5Division of Hematology/Oncology 6Department of Thoracic Surgery 7Department of Genetics and Genomic Sciences 8Department of Pathology 9Human Immune Monitoring Center Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA 10Department of Immunology, Weizmann Institute, Rehovot 76100, Israel 11Computational and Systems Biology Program, Sloan Kettering Institute, New York, NY 10065, USA 12Adaptive Biotechnologies Inc., Seattle, WA 98102, USA