Microphysiologic Human Tissue Constructs Reproduce Autologous Age-Specific BCG and HBV Primary Immunization in vitro

Sanchez-Schmitz G1,2,3, Stevens CR1, Bettencourt IA1, Flynn PJ1, Schmitz-Abe K2,3,4,5, Metser G1, Hamm D6, Jensen KJ7,8,9, Benn C7,8, Levy O1,2,3,5 1 Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States. 2 Precision Vaccines Program, Boston Children's Hospital, Boston, MA, United States. 3 Harvard Medical School, Harvard University, Boston, MA, United States. 4 Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, United States. 5 Broad Institute of Harvard and MIT, Cambridge, MA, United States. 6 Adaptive Biotechnologies, Seattle, WA, United States. 7 Research Center for Vitamins and Vaccines, Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark. 8 Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau. 9 Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs Lyngby, Denmark.