Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States

Wei SC1, Sharma R2, Anang NAS1, Levine JH3, Zhao Y4, Mancuso JJ1, Setty M3, Sharma P5, Wang J4, Pe'er D6, Allison JP7; 1Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 2 Computational and Systems Biology Program, Sloan Kettering Institute, New York, NY 10065, USA; Department of Applied Physics and Applied Mathematics, Columbia University, New York, NY 10027, USA. 3 Computational and Systems Biology Program, Sloan Kettering Institute, New York, NY 10065, USA. 4 Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 5 Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Parker Institute for Cancer Immunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 6 Computational and Systems Biology Program, Sloan Kettering Institute, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. 7 Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Parker Institute for Cancer Immunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: jallison@mdanderson.org.