Neoadjuvant Immunotherapy Leads to Pathological Responses in MMR-proficient and MMR-deficient Early-Stage Colon Cancers

Myriam Chalabi 1 2 3, Lorenzo F Fanchi 4 5, Krijn K Dijkstra 4 5, José G Van den Berg 6, Arend G Aalbers 7, Karolina Sikorska 8, Marta Lopez-Yurda 8 9, Cecile Grootscholten 10, Geerard L Beets 7 11, Petur Snaebjornsson 6, Monique Maas 12, Marjolijn Mertz 13, Vivien Veninga 4 5, Gergana Bounova 5 14, Annegien Broeks 15, Regina G Beets-Tan 11 12, Thomas R de Wijkerslooth 10, Anja U van Lent 16, Hendrik A Marsman 17, Elvira Nuijten 8, Niels F Kok 7, Maria Kuiper 10, Wieke H Verbeek 10, Marleen Kok 18 19, Monique E Van Leerdam 10, Ton N Schumacher 4 5, Emile E Voest 20 21 22, John B Haanen 4 18; 1Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands. m.chalabi@nki.nl. 2Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands. m.chalabi@nki.nl. 3Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands. m.chalabi@nki.nl. 4Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands. 5Oncode Institute, Utrecht, the Netherlands. 6Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands. 7Surgical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands. 8Biometrics, Netherlands Cancer Institute, Amsterdam, the Netherlands. 9Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. 10Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands. 11GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands. 12Radiology, Netherlands Cancer Institute, Amsterdam, the Netherlands. 13Bioimaging Facility, Netherlands Cancer Institute, Amsterdam, the Netherlands. 14Molecular Carcinogenesis, Netherlands Cancer Institute, Amsterdam, the Netherlands. 15Core Facility Molecular Pathology & Biobanking, Netherlands Cancer Institute, Amsterdam, the Netherlands. 16Gastroenterology & Hepatology, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. 17Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. 18Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands. 19Tumor Biology & Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands. 20Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands. e.voest@nki.nl. 21Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, the Netherlands. e.voest@nki.nl. 22Oncode Institute, Utrecht, the Netherlands. e.voest@nki.nl.