Neutrophil Expansion Defines an Immunoinhibitory Peripheral and Intratumoral Inflammatory Milieu in Resected Non-Small Cell Lung Cancer: A Descriptive Analysis of a Prospectively Immunoprofiled Cohort

Kyle G Mitchell 1, Lixia Diao 2, Tatiana Karpinets 3, Marcelo V Negrao 4, Hai T Tran 4, Edwin R Parra 5, Erin M Corsini 1, Alexandre Reuben 4, Lorenzo Federico 6, Chantale Bernatchez 6, Hitoshi Dejima 5, Alejandro Francisco-Cruz 5, Jing Wang 2, Mara B Antonoff 1, Ara A Vaporciyan 1, Stephen G Swisher 1, Tina Cascone 4, Ignacio I Wistuba 4 5, John V Heymach 4, Don L Gibbons 4 7, Jianjun Zhang 4, Cara L Haymaker # 8, Boris Sepesi # 9 1Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 2Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 3Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 4Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 5Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 6Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 7Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 8Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA CHaymaker@mdanderson.org BSepesi@MDAnderson.org. 9Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA CHaymaker@mdanderson.org BSepesi@MDAnderson.org. #Contributed equally.