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PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

Juneja et al.
Journal of Experimental Medicine
Papers
March 2017
Authors and Affiliates
Vikram R. Juneja,1,2,5 Kathleen A. McGuire,2,5 Robert T. Manguso,3,6 Martin W. LaFleur,2,5,6 Natalie Collins,4,6,8 W. Nicholas Haining,4,6,8 Gordon J. Freeman,7 and Arlene H. Sharpe2,5 1Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, 2Department of Microbiology and Immunobiology, 3Division of Medical Sciences, and 4Division of Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, MA 02115, 5Evergrande Center for Immunological Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, 6Department of Pediatric Oncology and 7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, 8Broad Institute of MIT and Harvard, Cambridge, MA 02142