Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

Twyman-Saint Victor C1,2, Rech AJ2, Maity A3,4, Rengan R3,4, Pauken KE5,6, Stelekati E5,6, Benci JL2,3, Xu B2,3, Dada H2,3, Odorizzi PM5,6, Herati RS1,6, Mansfield KD5,6, Patsch D3, Amaravadi RK1,4, Schuchter LM1,4, Ishwaran H7, Mick R4,8, Pryma DA4,9, Xu X4,10, Feldman MD4,10, Gangadhar TC1,4, Hahn SM3,4, Wherry EJ4,5,6, Vonderheide RH1,2,4,6, Minn AJ2,3,4,6 Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA1; Abramson Family Cancer Research Institute Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA2; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA3; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA4; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA5; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA6; Division of Biostatistics, Department of Public Heath Sciences, University of Miami, Miami, FL7; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA8; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA9; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA10