Suppression by Tfr cells leads to durable and selective inhibition of B cell effector function

Peter T Sage1,2, Noga Ron-Harel3, Vikram R Juneja1,2, Debattama R Sen4, Seth Maleri1,2, Waradon Sungnak2,5, Vijay K Kuchroo2,5, W Nicholas Haining4, Nicolas Chevrier6, Marcia Haigis3 & Arlene H Sharpe1,2,7 1Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA. 2Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts, USA. 3Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA. 4Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. 5Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. 6FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, USA. 7Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.