T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis

Caren Ramien,1,12 Erik C. Yusko,7,12 Jan Broder Engler,1 Stefanie Gamradt,8 Kostas Patas,1,11 Nils Schweingruber,1,5 Anne Willing,1 Sina Cathe ́ rine Rosenkranz,1,5 Anke Diemert,2 Anja Harrison,1,6 Marissa Vignali,7 Catherine Sanders,7 Harlan S. Robins,7,10 Eva Tolosa,4 Christoph Heesen,1,5 Petra C. Arck,3 Alexander Scheffold,9 Kenneth Chan,7 Ryan O. Emerson,7,13 Manuel A. Friese,1,13 and Stefan M. Gold1,8,13,14,* 1Institut fu€r Neuroimmunologie und Multiple Sklerose (INIMS), Universita ̈ tsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany 2Klinik fu€r Geburtshilfe und Pra ̈ natalmedizin, Universita ̈ tsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany 3Labor fu€r Experimentelle Feto-Maternale Medizin, Universita ̈ tsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany 4Institut fu€r Immunologie, Universita ̈ tsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany 5Klinik fu€r Neurologie, Universita ̈ tsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany 6Department of Psychology, University of Central Lancashire, Preston, PR1 2HE Lancashire, UK 7Adaptive Biotechnologies Corp., 1551 Eastlake Ave. E., Seattle, WA 98102, USA 8Charite ́ Universita ̈ tsmedizin Berlin, Klinik fu€r Psychiatrie und Medizinische Klinik m.S. Psychosomatik, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany 9Institut fu€r Immunologie, Universita ̈ tsklinikum Schleswig-Holstein, Arnold Heller Str. 3, 24105 Kiel, Germany 10Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109-1024, USA 11Laboratory for Biopathology and Immunology, Eginition University Hospital, 72-74 Vasilissis Sophias Ave., 11528 Athens, Greece 12These authors contributed equally 13Senior author 14Lead Contact