The effect of anti-CTLA4 treatment on peripheral and intra-tumoral T cells in patients with hepatocellular carcinoma

Agdashian D1, ElGindi M1, Xie C1, Sandhu M1, Pratt D2, Kleiner DE2, Figg WD3, Rytlewski JA4, Sanders C4, Yusko EC4, Wood B5, Venzon D6, Brar G1, Duffy AG1, Greten TF7,8, Korangy F1. 1 Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, Bethesda, MD, 20892, USA. 2 Laboratory of Pathology, Center for Cancer Research (CCR) National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 3 Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 4 Adaptive Biotechnologies, Seattle, WA, USA. 5 Center for Interventional Oncology, Radiology and Imaging Sciences and Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA. 6 Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 7 Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, Bethesda, MD, 20892, USA. tim.greten@nih.gov. 8 NCI CCR Liver Cancer Program, Bethesda, MD, USA.