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Ultra-deep T-cell receptor sequencing reveals the complexity and intratumour heterogeneity of T-cell clones in renal cell carcinomas

Marco et al.
Journal of Pathology
Papers
December 2013
Authors and Affiliates
Marco Gerlinger,1,2 Sergio A Quezada,3 Karl S Peggs,3 Andrew JS Furness,3,4 Rosalie Fisher,4 Teresa Marafioti,5Vishvesh H Shende,5 Nicholas McGranahan,1,6 Andrew J Rowan,1 Steven Hazell,4 David Hamm,7 Harlan S Robins,8Lisa Pickering,4 Martin Gore,4 David L Nicol,4 James Larkin,4 and Charles Swanton1,3 1Cancer Research UK, London Research Institute, UK, 2Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, London, UK, 3UCL Cancer Institute, London, UK, 4Royal Marsden Hospital, London, UK, 5Departments of Pathology and Histopathology, University College Hospital, London, UK, 6Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, UK, 7Adaptive Biotechnologies, Seattle, WA, USA, 8Fred Hutchinson Cancer Research Center, Seattle, WA, USA.