Therapeutic Area: Autoimmune

Expansion of the CD4 + effector T-cell repertoire characterizes peanut-allergic patients with heightened clinical sensitivity

Ruiter B., et al.
Allergy
Journal of Allergy and Clinical Immunology
September 2020
Authors and Affiliates
Bert Ruiter 1, Neal P Smith 2, Brinda Monian 3, Ang A Tu 3, Elizabeth Fleming 2, Yamini V Virkud 4, Sarita U Patil 4, Charles A Whittaker 5, J Christopher Love 3, Wayne G Shreffler 4; 1 Center for Immunology & Inflammatory Diseases, Massachusetts General Hospital, Boston, Mass; Harvard Medical School, Boston, Mass. Electronic address: bruiter@mgh.harvard.edu. 2 Center for Immunology & Inflammatory Diseases, Massachusetts General Hospital, Boston, Mass. 3 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Mass. 4 Center for Immunology & Inflammatory Diseases, Massachusetts General Hospital, Boston, Mass; Harvard Medical School, Boston, Mass; Food Allergy Center, Massachusetts General Hospital, Boston, Mass. 5 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Mass; The Barbara K. Ostrom (1978) Bioinformatics and Computing Facility in the Swanson Biotechnology Center, Massachusetts Institute of Technology, Cambridge, Mass.

Deep immune profiling of patients treated with lenalidomide and dexamethasone with or without daratumumab

Casneuf et al.
Leukemia
May 2020
Authors and Affiliates
Tineke Casneuf1 Homer C. Adams III2 Niels W.C.J. van de Donk3 Yann Abraham1 Jaime Bald2 Greet Vanhoof1 Koen Van der Borght1 Tina Smets1 Brad Foulk2 Karl C. Nielsen2 Joshua Rusbuldt2 Amy Axel2 Andrew Lysaght4 Hugo Ceulemans1 Frederik Stevenaert1 Saad Z. Usmani5 Torben Plesner6 Herve Avet-Loiseau7 Inger Nijhof3 Tuna Mutis3 Jordan M. Schecter8 Christopher Chiu2 Nizar J. Bahlis9 1 Janssen Research & Development, Beerse, Belgium 2 Janssen Research & Development, LLC, Spring House, PA, USA Department of Hematology, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands 3 Vejle Hospital and University of Southern Denmark, 4 Immuneering Corp, Cambridge, MA, USA 5 Levine Cancer Institute/Carolinas Healthcare System, Charlotte, NC, USA 6 Vejle, Denmark 7 Toulouse, France 8 9 Janssen Research & Development, LLC, Raritan, NJ, USA Arnie Charbonneau Cancer Research Institute, University of Calgary, Calgary, AB, Canada

CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence

Krummey et al.
Cell Reports
February 2020
Authors and Affiliates
Scott M. Krummey,1,2,7,* Anna B. Morris,1 Jesica R. Jacobs,3 Donald J. McGuire,4 Satomi Ando,4 Katherine P. Tong,1 Weiwen Zhang,1 Jennifer Robertson,1 Sara A. Guasch,1 Koichi Araki,4,6 Christian P. Larsen,1 Brian D. Evavold,3 Haydn T. Kissick,5 and Mandy L. Ford1 1Emory Transplant Center, Emory University School of Medicine, Atlanta, GA, USA 2Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA 3Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA 4Department of Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA, USA 5Department of Urology, Emory University School of Medicine, Atlanta, GA, USA 6Present address: Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA 7Lead Contact *Correspondence: skrumme@emory.edu https://doi.org/10.1016/j.celrep.2020.01.016

Extensive intrathecal T cell renewal following hematopoietic transplantation for multiple sclerosis

Harris et al.
JCI Insight
January 2020
Authors and Affiliates
Kristina M. Harris1, Noha Lim1, Paul Lindau2, Harlan Robins2,3, Linda M. Griffith4, Richard A. Nash5, Laurence A. Turka1,6, and Paolo A. Muraro7 1Immune Tolerance Network (ITN), Bethesda, Maryland, USA 2Fred Hutchinson Cancer Research Center, Seattle, Washington, USA 3Adaptive Biotechnologies, Seattle, Washington, USA 4 Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA 5Colorado Blood Cancer Institute at Presbyterian / St. Luke’s, Denver, Colorado, USA 6Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA 7Department of Brain Sciences, Department of Medicine, Imperial College London, London, United Kingdom

A critical insulin TCR contact residue selects high affinity and pathogenic insulin specific T cells

Bettini et al.
Diabetes
December 2019
Authors and Affiliates
Maria Bettini,1,2,7 Marissa A. Scavuzzo,4,6 Baoyu Liu,5 Elizabeth Kolawole,5 Lin Guo,1 Brian D. Evavold,5 Malgorzata Borowiak2,3,4 and Matthew L. Bettini1,2,7 1Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 2 USA. 3 4 5Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112 6 Present address: Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH, 44106 USA 7Present address: Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112

Lack of specific T- and B-cell clonal expansions in multiple sclerosis patients with progressive multifocal leukoencephalopathy

Bertoli et al.
Scientific Reports
November 2019
immuneAccess
Authors and Affiliates
Diego Bertoli,1,2 Alessandra Sottini,1 Ruggero Capra,3 Cristina Scarpazza,3,4 Roberto Bresciani,2 Luigi D. Notarangelo,5 and Luisa Imberti1; 1Centro di Ricerca Emato-oncologica AIL (CREA), Diagnostic Department, ASST Spedali Civili, Brescia, Italy 2Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy 3Multiple Sclerosis Center, ASST Spedali Civili, Brescia, Italy 4Department of General Psychology, University of Padova, Padova, Italy 5Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States

Synovial IL-17A+ CD8+ T cells display a polyfunctional, pro-inflammatory and tissue-resident memory phenotype and function in psoriatic arthritis

Steel et al.
Arthritis and Rheumatology
November 2019
immuneAccess
Authors and Affiliates
Steel KJA1, Srenathan U1, Ridley M1, Durham LE1, Wu SY1, Ryan SE1, Hughes CD1,2, Chan E2, Kirkham BW2, Taams LS1; 1 Centre for Inflammation Biology and Cancer Immunology (CIBCI), Department of Inflammation Biology, School of Immunology & Microbial Sciences, King's College London. 2 Department Rheumatology, Guy's & St Thomas' Hospital, London, UK.

Polyfunctional, Proinflammatory, Tissue-Resident Memory Phenotype and Function of Synovial Interleukin-17A+CD8+ T Cells in Psoriatic Arthritis

Steel KJA, et al.
Arthritis and Rheumatology
November 2019
Authors and Affiliates
Kathryn J A Steel 1, Ushani Srenathan 1, Michael Ridley 1, Lucy E Durham 1, Shih-Ying Wu 1, Sarah E Ryan 1, Catherine D Hughes 2, Estee Chan 3, Bruce W Kirkham 3, Leonie S Taams 1; 1 King's College London, London, UK. 2 King's College London, Guy's Hospital, and St. Thomas' Hospital, London, UK. 3 Guy's Hospital and St. Thomas' Hospital, London, UK.

T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis

Ramien et al.
Cell Reports
October 2019
immuneAccess
Authors and Affiliates
Caren Ramien,1,12 Erik C. Yusko,7,12 Jan Broder Engler,1 Stefanie Gamradt,8 Kostas Patas,1,11 Nils Schweingruber,1,5 Anne Willing,1 Sina Cathe ́ rine Rosenkranz,1,5 Anke Diemert,2 Anja Harrison,1,6 Marissa Vignali,7 Catherine Sanders,7 Harlan S. Robins,7,10 Eva Tolosa,4 Christoph Heesen,1,5 Petra C. Arck,3 Alexander Scheffold,9 Kenneth Chan,7 Ryan O. Emerson,7,13 Manuel A. Friese,1,13 and Stefan M. Gold1,8,13,14,* 1Institut fu€r Neuroimmunologie und Multiple Sklerose (INIMS), Universita ̈ tsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany 2Klinik fu€r Geburtshilfe und Pra ̈ natalmedizin, Universita ̈ tsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany 3Labor fu€r Experimentelle Feto-Maternale Medizin, Universita ̈ tsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany 4Institut fu€r Immunologie, Universita ̈ tsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany 5Klinik fu€r Neurologie, Universita ̈ tsklinikum Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany 6Department of Psychology, University of Central Lancashire, Preston, PR1 2HE Lancashire, UK 7Adaptive Biotechnologies Corp., 1551 Eastlake Ave. E., Seattle, WA 98102, USA 8Charite ́ Universita ̈ tsmedizin Berlin, Klinik fu€r Psychiatrie und Medizinische Klinik m.S. Psychosomatik, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany 9Institut fu€r Immunologie, Universita ̈ tsklinikum Schleswig-Holstein, Arnold Heller Str. 3, 24105 Kiel, Germany 10Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109-1024, USA 11Laboratory for Biopathology and Immunology, Eginition University Hospital, 72-74 Vasilissis Sophias Ave., 11528 Athens, Greece 12These authors contributed equally 13Senior author 14Lead Contact

Deletion of donor-reactive T cell clones after human liver transplant

Savage et al.
American Journal of Transplantation
September 2019
immuneAccess
Authors and Affiliates
Savage TM1, Shonts BA1, Lau S1, Obradovic A1, Robins H2, Shaked A3, Shen Y4, Sykes M1,5,6; 1 Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, New York. 2 Fred Hutchinson Cancer Research Center, Adaptive Biotechnologies, Inc., Seattle, Washington. 3 Division of Transplant Surgery, University of Pennsylvania, Philadelphia, Pennsylvania. 4 Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, New York. 5 Department of Microbiology & Immunology, Columbia University Medical Center, Columbia University, New York, New York. 6 Department of Surgery, Columbia University Medical Center, Columbia University, New York, New York.