Therapeutic Area: Oncology

A phase Ib trial of pembrolizumab plus paclitaxel or flat-dose capecitabine in 1st/2nd line metastatic triple-negative breast cancer

Page DB, et al.
NPJ Breast Cancer
August 2023
immuneAccess
Authors and Affiliates
David B Page 1, Joanna Pucilowska 2, Brie Chun 2, Isaac Kim 2, Katherine Sanchez 2, Nicole Moxon 2, Staci Mellinger 2, Yaping Wu 2, Yoshinobu Koguchi 2, Valerie Conrad 2, William L Redmond 2, Maritza Martel 2, Zhaoyu Sun 2, Mary B Campbell 2, Alison Conlin 2, Anupama Acheson 2, Reva Basho 3,4, Philomena McAndrew 3, Mary El-Masry 3, Dorothy Park 3, Laura Bennetts 2, Robert S Seitz 5, Tyler J Nielsen 5, Kimberly McGregor 5, Venkatesh Rajamanickam 2, Brady Bernard 2, Walter J Urba 2, Heather L McArthur 3,6; 1 Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA. david.page2@providence.org. 2 Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA. 3 Cedars Sinai Medical Center, Los Angeles, CA, USA. 4 Ellison Institute for Transformative Medicine, Los Angeles, CA, USA. 5 Oncocyte Corporation, Irving, CA, USA. 6 UT Southwestern Medical Center, Dallas, TX, USA.

Cell surface marker-based capture of neoantigen-reactive CD8+ T-cell receptors from metastatic tumor digests

Chatani PD, et al.
Journal for ImmunoTherapy of Cancer
August 2023
Authors and Affiliates
Praveen D Chatani 1, Frank J Lowery 2, Neilesh B Parikh 1, Kyle J Hitscherich 1, Rami Yossef 1, Victoria Hill 1, Jared J Gartner 1, Biman Paria 1, Maria Florentin 1, Satyajit Ray 1, Alakesh Bera 1, Maria Parkhust 1, Paul Robbins 1, Sri Krishna 2, Steven A Rosenberg 2; 1 Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. 2 Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA sri.krishna@nih.gov frank.lowery@nih.gov sar@mail.nih.gov.

Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells

Islam SMR, et al.
Cancer Research Communication
August 2023
Authors and Affiliates
S M Rafiqul Islam 1,2, Takuya Maeda 1,2, Naritaka Tamaoki 1,2, Meghan L Good 1,2, Rigel J Kishton 1,2, Biman C Paria 1, Zhiya Yu 1, Marta Bosch-Marce 1, Nicole M Bedanova 3, Chengyu Liu 4, Michael J Kruhlak 5, Nicholas P Restifo 1,2, Raul Vizcardo 1,2; 1 Surgery Branch, NCI, NIH, Bethesda, Maryland. 2 Center for Cell-Based Therapy, NCI, NIH, Bethesda, Maryland. 3 Experimental Pathology Laboratory, NCI, NIH, Bethesda, Maryland. 4 Transgenic Core, Division of Intramural Research, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland. 5 CCR Microscopy Core Facility, NCI, NIH, Bethesda, Maryland.

Addition of Metastasis-Directed Therapy to Intermittent Hormone Therapy for Oligometastatic Prostate Cancer: The EXTEND Phase 2 Randomized Clinical Trial

Tang C, et al.
JAMA Oncology
August 2023
Authors and Affiliates
Chad Tang 1,2,3, Alexander D Sherry 1, Cara Haymaker 2, Tharakeswara Bathala 4, Suyu Liu 5, Bryan Fellman 5, Lorenzo Cohen 6, Ana Aparicio 7, Amado J Zurita 7, Alexandre Reuben 8, Enrica Marmonti 2, Stephen G Chun 1, Jay P Reddy 1, Amol Ghia 1, Sean McGuire 1, Eleni Efstathiou 7, Jennifer Wang 7, Jianbo Wang 7, Patrick Pilie 7, Craig Kovitz 7, Weiliang Du 9, Samantha J Simiele 9, Rachit Kumar 10, Yerko Borghero 10, Zheng Shi 11, Brian Chapin 12, Daniel Gomez 13, Ignacio Wistuba 2, Paul G Corn 7; 1 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston. 2 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston. 3 Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston. 4 Department of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston. 5 Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston. 6 Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston. 7 Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston. 8 Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston. 9 Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston. 10 Department of Radiation Oncology, Banner MD Anderson Cancer Center, Gilbert, Arizona. 11 Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio. 12 Department of Urology, The University of Texas MD Anderson Cancer Center, Houston. 13 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

Immunologic Predictors for Clinical Responses during Immune Checkpoint Blockade in Patients with Myelodysplastic Syndromes

Lee SE, et al.
Clinical Cancer Research
August 2023
Authors and Affiliates
Sung-Eun Lee 1,2, Feng Wang 3, Maison Grefe 4, Abel Trujillo-Ocampo 4, Wilfredo Ruiz-Vasquez 4, Koichi Takahashi 3,5, Hussein A Abbas 5, Pamella Borges 5,6, Dinler Amaral Antunes 6, Gheath Al-Atrash 1,4,5, Naval Daver 5, Jeffrey J Molldrem 1,4,5, Andrew Futreal 3, Guillermo Garcia-Manero 4, Jin S Im 1,4,5; 1 Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas. 2 Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. 3 Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas. 4 Department of Hematopoietic Biology and Malignancy, Division of Cancer Medicine, The University of Texas M.D, Anderson Cancer Center, Houston, Texas. 5 Department of Leukemia, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas. 6 Department of Biology and Biochemistry, The University of Houston, Houston, Texas.

TET2 guards against unchecked BATF3-induced CAR T cell expansion

Jain N, et al.
Nature
August 2023
Authors and Affiliates
Nayan Jain 1,2, Zeguo Zhao 2, Judith Feucht 2,3, Richard Koche 4, Archana Iyer 2, Anton Dobrin 1,2, Jorge Mansilla-Soto 2, Julie Yang 4, Yingqian Zhan 4, Michael Lopez 2, Gertrude Gunset 2, Michel Sadelain 5; 1 Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Centre, New York, NY, USA. 2 Centre for Cell Engineering and Immunology Program, Memorial Sloan Kettering Cancer Centre, New York, NY, USA. 3 University Children's Hospital, Tübingen, Germany. 4 Centre for Epigenetics Research, Memorial Sloan Kettering Cancer Centre, New York, NY, USA. 5 Centre for Cell Engineering and Immunology Program, Memorial Sloan Kettering Cancer Centre, New York, NY, USA. m-sadelain@ski.mskcc.org.

A Specific CD44lo CD25lo Subpopulation of Regulatory T Cells Inhibits Anti-Leukemic Immune Response and Promotes the Progression in a Mouse Model of Chronic Lymphocytic Leukemia

Goral A, et al.
Frontiers in Immunology
August 2023
Authors and Affiliates
Agnieszka Goral 1, Malgorzata Firczuk 1, Klaudyna Fidyt 1, Marta Sledz 1, Francesca Simoncello 2, Karolina Siudakowska 1, Giulia Pagano 3, Etienne Moussay 3, Jérôme Paggetti 3, Patrycja Nowakowska 1, Stefania Gobessi 4, Joanna Barankiewicz 5, Aleksander Salomon-Perzynski 5, Federica Benvenuti 2, Dimitar G Efremov 4, Przemyslaw Juszczynski 5, Ewa Lech-Maranda 5, Angelika Muchowicz 1; 1 Department of Immunology, Medical University of Warsaw, Warsaw, Poland. 2 Cellular Immunology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy. 3 Tumor-Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg. 4 Molecular Hematology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy. 5 Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.

Analysis of thymic generation of shared T-cell receptor α repertoire associated with recognition of tumor antigens shows no preference for neoantigens over wild-type antigens

Mattila J, et al.
cancer medicine
August 2023
Authors and Affiliates
Joonatan Mattila 1, Silja Sormunen 2, Nelli Heikkilä 1 3, Ilkka P Mattila 4, Jari Saramäki 2, T Petteri Arstila 1; 1 Research Programs Unit, Translational Immunology, Haartmaninkatu 3 (PL 21) 00014, and Medicum, University of Helsinki, Helsinki, Finland. 2 Department of Computer Science, Aalto University, Espoo, Finland. 3 Faculty of Medicine, Center for Vaccinology, Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland. 4 Department of Pediatric Cardiac and Transplantation Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland.

Naive T cells inhibit the outgrowth of intractable antigen-activated memory T cells: implications for T-cell immunotherapy

Sharma S, et al.
Journal for ImmunoTherapy of Cancer
August 2023
Authors and Affiliates
Sandhya Sharma 1,2, Mae Woods 2, Naren U Mehta 2, Tim Sauer 2, Kathan S Parikh 2, Michael Schmuck-Henneresse 2,3, Huimin Zhang 2, Birju Mehta 2, Malcolm K Brenner 2,4,5,6, Helen E Heslop 1,2,4,5,6, Cliona M Rooney 7,2,4,6,8,9; 1 Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA. 2 Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital, Houston, Texas, USA. 3 Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Charitéplatz 1, Berlin, Germany. 4 Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA. 5 Department of Medicine, Baylor College of Medicine, Houston, Texas, USA. 6 Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas, USA. 7 Graduate Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA crooney@bcm.edu. 8 Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA. 9 Department of Pathology-Immunology, Baylor College of Medicine, Houston, Texas, USA.

Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy

Bhatia V, et al.
Nature Communications
August 2023
immuneAccess
Authors and Affiliates
Vipul Bhatia 1, Nikhil V Kamat 2, Tiffany E Pariva 1, Li-Ting Wu 1, Annabelle Tsao 1, Koichi Sasaki 3, Huiyun Sun 1, Gerardo Javier 1, Sam Nutt 1, Ilsa Coleman 1, Lauren Hitchcock 1, Ailin Zhang 1, Dmytro Rudoy 1, Roman Gulati 4, Radhika A Patel 1, Martine P Roudier 5, Lawrence D True 6, Shivani Srivastava 1, Colm M Morrissey 5, Michael C Haffner 1,6,7, Peter S Nelson 1,2,4,5,6,7, Saul J Priceman 8,9, Jun Ishihara 10, John K Lee 11,12,13,14; 1 Human Biology Division, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA, 98109, USA. 2 Division of Medical Oncology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA. 3 Department of Bioengineering, Imperial College London, 86 Wood Lane, London, W12 0BZ, UK. 4 Public Health Sciences Division, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA, 98109, USA. 5 Department of Urology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA. 6 Department of Pathology and Laboratory Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA. 7 Clinical Research Division, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA, 98109, USA. 8 Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. 9 Department of Immuno-Oncology, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. 10 Department of Bioengineering, Imperial College London, 86 Wood Lane, London, W12 0BZ, UK. j.ishihara@imperial.ac.uk. 11 Human Biology Division, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA, 98109, USA. jklee5@fredhutch.org. 12 Division of Medical Oncology, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA. jklee5@fredhutch.org. 13 Department of Pathology and Laboratory Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA. jklee5@fredhutch.org. 14 Clinical Research Division, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA, 98109, USA. jklee5@fredhutch.org.