Therapeutic Area: Oncology

Intratumoral heterogeneity and clonal evolution in liver cancer

Losic et al.
Nature Communications
January 2020
immuneAccess
Authors and Affiliates
Losic B1,2,3, Craig AJ4, Villacorta-Martin C4, Martins-Filho SN4,5, Akers N1,6, Chen X1, Ahsen ME1, von Felden J4,7, Labgaa I4,8, DʹAvola D4,9, Allette K1,2, Lira SA10, Furtado GC10, Garcia-Lezana T4, Restrepo P1, Stueck A11, Ward SC12, Fiel MI12, Hiotis SP13, Gunasekaran G13, Sia D4, Schadt EE2,14, Sebra R1,2,14, Schwartz M13, Llovet JM4,15,16, Thung S12, Stolovitzky G1,17, Villanueva A18,19; 1 Department of Genetics and Genomic Sciences, Cancer Immunology Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 2 Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 3 Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 4 Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 5 Department of Pathology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil. 6 Adaptive Biotechnologies, Seattle, WA, USA. 7 I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 8 Department of Visceral Surgery, Lausanne University Hospital CHUV, Lausanne, Switzerland. 9 Liver Unit and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Clínica Universidad de Navarra, Pamplona, Spain. 10 Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 11 Department of Pathology, Dalhousie University, Halifax, NS, Canada. 12 Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 13 Department of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 14 Sema4, a Mount Sinai venture, Stamford, CT, USA. 15 Liver Cancer Translational Research Laboratory, BCLC Group, IDIBAPS, Hospital Clinic, Universitat de Barcelona, Barcelona, Catalonia, Spain. 16 Institució Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain. 17 IBM T. J. Watson Research Center, Yorktown Heights, New York, NY, USA. 18 Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. augusto.villanueva@mssm.edu. 19 Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. augusto.villanueva@mssm.edu.

Predominance of central memory T cells with high T-cell receptor repertoire diversity is associated with response to PD-1/PD-L1 inhibition in Merkel cell carcinoma

Spassova et al.
Clinical Cancer Research
January 2020
Authors and Affiliates
Ivelina Spassova1*, Selma Ugurel2*, Patrick Terheyden3, Antje Sucker2, Jessica Hassel4, Cathrin Ritter1, Linda Kubat1, Daniel Habermann5, Farnoush Farahpour5, Mohammadkarim Saeedghalati5, Lukas Peiffer1,6, Rajiv Kumar6,7, David Schrama8, Daniel Hoffmann5, Dirk Schadendorf2, Jürgen C. Becker1,2,6* 1Translational Skin Cancer Research, German Consortium for Translational Cancer Research (Deutsches Konsortium für Translationale Krebsforschung; DKTK), Essen, Germany. 2Department of Dermatology, University Hospital of Essen, Essen, Germany. 3Department of Dermatology, University Hospital of Lübeck, Lübeck, Germany. 4Department of Dermatology, University Hospital of Heidelberg, Germany. 5Bioinformatics and Computational Biophysics, University of Duisburg-Essen, Essen, Germany. 6German Cancer Research Center (Deutsches Krebsforschungs Zentrum, DKFZ), Heidelberg, Germany 7Division of Molecular Genetic Epidemiology, Heidelberg, Germany. 8Department of Dermatology, University Hospital of Würzburg, Germany. *equal contribution

Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy

Sheih et al.
Nature Communications
January 2020
Authors and Affiliates
Sheih A1, Voillet V2, Hanafi LA1, DeBerg HA3, Yajima M4, Hawkins R1, Gersuk V3, Riddell SR1,5,6, Maloney DG1,5,6, Wohlfahrt ME1, Pande D1, Enstrom MR1, Kiem HP1,5,7, Adair JE1,5,6, Gottardo R2,5,6, Linsley PS3, Turtle CJ8,9,10; 1 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA. 2 Vaccine and Infectious Disease Division and Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA. 3 Benaroya Research Institute at Virginia Mason, Seattle, Washington, 98101, USA. 4 Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, 02215, USA. 5 Department of Medicine, University of Washington, Seattle, Washington, USA. 6 Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA. 7 Department of Pathology, University of Washington, Seattle, Washington, USA. 8 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA. cturtle@fredhutch.org. 9 Department of Medicine, University of Washington, Seattle, Washington, USA. cturtle@fredhutch.org. 10 Integrated Immunotherapy Research Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA. cturtle@fredhutch.org

Identification of human CD4+ T cell populations with distinct antitumor activity

Nelson et al.
bioRxiv
January 2020
Authors and Affiliates
Michelle H. Nelson†1,2, Hannah M. Knochelmann†1,2, Stefanie R. Bailey1,2, Logan W. Huff1,2, 4 Jacob S. Bowers1,2, Kinga Majchrzak1,2, Megan M. Wyatt1,2, Mark P. Rubinstein1,3, Shikhar 5 Mehrotra1,3, Michael I. Nishimura4, Kent E. Armeson5, Paul G. Giresi6, Michael J. Zilliox7, Hal 6 E. Broxmeyer8, Chrystal M. Paulos1,2*; †Contributed equally to this work *Corresponding author; Affiliations: 1Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC, USA. 2Department of Dermatology & Dermatologic Surgery, Medical University of South Carolina, SC, USA. 3Department of Surgery, Medical University of South Carolina, Charleston, SC, USA. 4Department of Surgery, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA. 5Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA. 6Epinomics, Menlo Park, CA, USA. 7Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA. 8Department of Microbiology & Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.

Somatic mutations and T-cell clonality in patients with immunodeficiency

Savola et al.
Haematologica
December 2019
Authors and Affiliates
Savola P1, Martelius T2, Kankainen M3, Huuhtanen J1, Lundgren S1, Koski Y1, Eldfors S3, Kelkka T1, Keränen MAI1, Ellonen P3, Kovanen PE4, Kytölä S5, Saarela J3, Lähdesmäki H6, Seppänen MRJ7, Mustjoki S8; 1 Hematology Research Unit Helsinki, University of Helsinki, HUS, Helsinki, Finland. 2 Adult Immunodeficiency Unit, Infectious Diseases, HUS Helsinki University Hospital, Finland. 3 Institute for Molecular Medicine Finland (FIMM), HILIFE, University of Helsinki, Finland. 4 Dept. of Pathology, University of Helsinki and HUSLAB, HUS Helsinki University Hospital, Finland. 5 Laboratory of Genetics, HUSLAB, HUS Helsinki University Hospital, Finland. 6 Department of Computer Science, Aalto University School of Science, Finland. 7 Rare Diseases Center & Pediatric Research Center, HUS Helsinki University Hospital, Finland. 8 Hematology Research Unit Helsinki, University of Helsinki, HUS, Helsinki, Finland; satu.mustjoki@helsinki.fi.

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

Jansen et al.
Nature
December 2019
Authors and Affiliates
Caroline S. Jansen1, Nataliya Prokhnevska1, Viraj A. Master1,2, Martin G. Sanda1,2, Jennifer W. Carlisle2,3, Mehmet Asim Bilen2,3, Maria Cardenas1, Scott Wilkinson4, Ross Lake4, Adam G. Sowalsky4, Rajesh M. Valanparambil5,6, William H. Hudson5,6, Donald McGuire5,6, Kevin Melnick1, Amir I. Khan1, Kyu Kim1, Yun Min Chang5, Alice Kim1, Christopher P. Filson1,2, Mehrdad Alemozaffar1,2, Adeboye O. Osunkoya1,2,7, Patrick Mullane7, Carla Ellis7, Rama Akondy5,6, Se Jin Im5,6, Alice O. Kamphorst8, Adriana Reyes1, Yuan Liu2,9 & Haydn Kissick1,2,5,6* 1Department of Urology, Emory University School of Medicine, Atlanta, GA, USA. 2Winship Cancer Institute of Emory University, Atlanta, GA, USA. 3Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, GA, USA. 4Laboratory of Genitourinary Cancer Pathogenesis, National Cancer Institute, Bethesda, MD, USA. 5Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA. 6Emory Vaccine Centre, Emory University School of Medicine, Atlanta, GA, USA. 7Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA. 8Department of Oncological Sciences, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. 9Rollins School of Public Health, Emory University, Atlanta, GA, USA. *e-mail: haydn.kissick@emory.edu

Massive clonal expansion of medulloblastoma-specific T cells during adoptive cellular therapy

Flores et al.
Science Advances
November 2019
Authors and Affiliates
Flores C1, Wildes T1, Dean BD1, Moore G1, Drake J1, Abraham R1, Gil J1, Yegorov O1, Yang C1, Dean J1, Moneypenny C1, Shin D1,2, Pham C1, Krauser J1, King J1, Grant G3, Driscoll T4, Kurtzberg J4, McLendon R5, Gururangan S1,6, Mitchell D1; 1 University of Florida Brain Tumor Immunotherapy Program, Preston A. Wells, Jr. Center for Brain Tumor Therapy, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute, University of Florida, Gainesville, FL, USA. 2 U.S. Army, 1600 Spearhead Division Ave., Fort Knox, KY, USA. 3 Department of Neurosurgery, Stanford University Medical Center, Palo Alto, CA, USA. 4 Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. 5 Department of Pathology, Duke University Medical Center, Durham, NC, USA. 6 Department of Pediatrics, University of Florida, Gainesville, FL, USA.

Loss of Setd4 delays radiation-induced thymic lymphoma in mice

Feng et al.
DNA Reapir
November 2019
Authors and Affiliates
Feng X1, Lu H1, Yue J1, Schneider N1, Liu J1, Denzin LK2, Chan CS3, De S3, Shen Z4; 1 Rutgers Cancer Institute of New Jersey, Department of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA. 2 Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA. 3 Center for Systems and Computational Biology, Rutgers Cancer Institute of New Jersey, Rutgers the State University of New Jersey, New Brunswick, NJ 08901, USA. 4 Rutgers Cancer Institute of New Jersey, Department of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08903, USA. Electronic address: shenzh@cinj.rutgers.edu.

Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy

Chowell et al.
Nature Medicine
November 2019
Authors and Affiliates
Chowell D1,2, Krishna C3, Pierini F4, Makarov V1,2, Rizvi NA5, Kuo F2, Morris LGT2,6, Riaz N2,7, Lenz TL8, Chan TA9,10,11,12; 1 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 2 Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 3 Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 4 Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Plön, Germany. 5 Department of Medicine, Columbia University Medical Center, New York, NY, USA. 6 Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 7 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 8 Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology, Plön, Germany. lenz@post.harvard.edu. 9 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 10 Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 11 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. chant@mskcc.org. 12 Weill Cornell School of Medicine, New York, NY, USA. chant@mskcc.org.

Compartmental analysis of T cell clonal dynamics as a function of pathologic response to neoadjuvant PD-1 blockade in resectable non-small cell lung cancer

Zhang et al.
Clinical Cancer Research
November 2019
Authors and Affiliates
Jiajia Zhang1,2, Zhicheng Ji3 , Justina X. Caushi1,2, Margueritta El Asmar1,2, Valsamo Anagnostou1,2, Tricia R. Cottrell1,2,4, Hok Yee Chan1,2, Prerna Suri1,2, Haidan Guo1,2, Taha Merghoub5 , Jamie E. Chaft5 , Joshua E. Reuss1,2, Ada J. Tam1,2, Richard L. Blosser1,2, Mohsen Abu-Akeel5 , John-William Sidhom1,2, Ni Zhao3 , Jinny S. Ha2,6, David R. Jones7 , Kristen A. Marrone1,2, Jarushka Naidoo1,2, Edward Gabrielson1,2, Janis M. Taube1,2,4, Victor E. Velculescu1,2, Julie R. Brahmer1,2, Franck Housseau1,2, Matthew D. Hellmann5 , Patrick M. Forde1,2, Drew M. Pardoll1,2, Hongkai Ji3 , and Kellie N. Smith1,2; 1 The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland. 2 The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. 3 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland. 4 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. 5 Thoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, New York, New York. 6 Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. 7 Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center, New York, New York