Therapeutic Area: Oncology

Integrative clinical genomics of metastatic cancer

Robinson et al.
Nature
Papers
August 2017
Authors and Affiliates
Dan R. Robinson1,2, Yi-Mi Wu1,2, Robert J. Lonigro1, Pankaj Vats1, Erin Cobain3, Jessica Everett3, Xuhong Cao1, Erica Rabban1, Chandan Kumar-Sinha1,2, Victoria Raymond3, Scott Schuetze3, Ajjai Alva3, Javed Siddiqui1,2, Rashmi Chugh3, Francis Worden3, Mark M. Zalupski3, Jeffrey Innis4, Rajen J. Mody4, Scott A. Tomlins1,2, David Lucas2, Laurence H. Baker3, Nithya Ramnath3, Ann F. Schott3, Daniel F. Hayes3, Joseph Vijai5, Kenneth Offit5, Elena M. Stoffel3, J. Scott Roberts6, David C. Smith3, Lakshmi P. Kunju1,2, Moshe Talpaz7, Marcin Cieślik1,2 & Arul M. Chinnaiyan1,2,7,8,9 1Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA. 2Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA. 3Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA. 4Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA. 5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA. 6Department of Health Behavior & Health Education, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA. 7Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA. 8Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA. 9Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.

Concurrent PD-1 Blockade Negates the Effects of OX40 Agonist Antibody in Combination Immunotherapy through Inducing T-cell Apoptosis

Shrimali et al.
Cancer Immunology Research
Papers
August 2017
Authors and Affiliates
Rajeev K. Shrimali1, Shamim Ahmad1, Vivek Verma1, Peng Zeng1, Sudha Ananth1, Pankaj Gaur1, Rachel M. Gittelman2, Erik Yusko2, Catherine Sanders2, Harlan Robins2,3, Scott A. Hammond4, John E. Janik1, Mikayel Mkrtichyan1, Seema Gupta1, and Samir N. Khleif1 1Georgia Cancer Center, Augusta University, Augusta, Georgia. 2Adaptive Biotechnologies, Seattle, Washington. 3Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington. 4MedImmune LLC, Gaithersburg, Maryland.

An adolescent with granulomatous mycosis fungoides infiltrating skeletal muscle successfully treated with oral prednisone

Lewis et al.
Journal of the American Academy of Dermatology
Papers
July 2017
Authors and Affiliates
Daniel J. Lewis, BA,a,b Ashley E. Turkeltaub, BS,a Julia Dai, MD,c Priyadharsini Nagarajan, MD, PhD,d Kerri E. Rieger, MD, PhD,c,e Cesar A. Nunez, MD,f Youn H. Kim, MD,c and Madeleine Duvic, MDb School of Medicine, Baylor College of Medicinea; The Departments of Dermatology,b Pathology,d and Pediatric Oncology,f the University of Texas MD Anderson Cancer Center; and Departments of Dermatologyc and Pathology,e Stanford University.

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

O'Rourke et al.
Papers
Science Translational Medicine
July 2017
Authors and Affiliates
Donald M. O’Rourke,1 MacLean P. Nasrallah,2 Arati Desai,3 Jan J. Melenhorst,4 Keith Mansfield,5 Jennifer J. D. Morrissette,6 Maria Martinez-Lage,2 Steven Brem,1 Eileen Maloney,1 Angela Shen,7 Randi Isaacs,5 Suyash Mohan,8 Gabriela Plesa,4 Simon F. Lacey,4 Jean-Marc Navenot,4 Zhaohui Zheng,4 Bruce L. Levine,4 Hideho Okada,9 Carl H. June,4 Jennifer L. Brogdon,5 Marcela V. Maus10 1Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 2Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 3Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 4Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA. 5Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA. 6Division of Precision and Computational Diagnostics, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 7Novartis Oncology, East Hanover, NJ 07936, USA. 8Division of Neuroradiology, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. 9Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA. 10Cellular Immunotherapy Program, Cancer Center and Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA.

Comprehensive T cell immunophenotyping and next generation sequencing from HPV-positive and -negative head and neck squamous cell carcinomas

Poropatich et al.
Journal of Pathology
Papers
July 2017
Authors and Affiliates
Kate Poropatich1, Joel Fontanarosa2, Suchitra Swaminathan3, Dave Dittmann1, Siqi Chen4, Sandeep Samant2, Bin Zhang4 1Department of Pathology, Northwestern University Feinberg School of Medicine Chicago, IL 60611, USA. 2Department of Otolaryngology, Northwestern University, Feinberg Medical School, Chicago, IL 60611, USA. 3Robert H Lurie Comprehensive Cancer Center, Department of Medicine-Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. 4Robert H Lurie Comprehensive Cancer Center, Department of Medicine-Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Vaccination establishes clonal relatives of germinal center T cells in the blood of humans

Heit et al.
Journal of Experimental Medicine
Papers
June 2017
Authors and Affiliates
Antje Heit,1 Frank Schmitz,3 Sarah Gerdts,1 Britta Flach,1 Miranda S. Moore,1 Jonathan A. Perkins,4,8 Harlan S. Robins,2,9 Alan Aderem,3 Paul Spearman,10 Georgia D. Tomaras,11 Stephen C. De Rosa,1,5 and M. Juliana McElrath1,5,6,7 1Vaccine and Infectious Disease Division and 2Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 3Center for Infectious Disease Research, Seattle, WA, 4Department of Otolaryngology, 5Department of Laboratory Medicine, 6Department of Medicine, and 7Department of Global Health, University of Washington, Seattle, WA, 8Seattle Children's Hospital Research Institute, Seattle, WA, 9Adaptive Biotechnologies Corporation, Seattle, WA, 10Pediatric Infectious Diseases, Cincinnati Children's Hospital, Cincinnati, OH, 11Duke Human Vaccine Institute, Duke University, Durham, NC

Dual Targeting Nanoparticle Stimulates the Immune System To Inhibit Tumor Growth

Kosmides et al.
ACS Nano
Papers
June 2017
Authors and Affiliates
Alyssa K. Kosmides†‡§, John-William Sidhom†§, Andrew Fraser†§, Catherine A. Bessell§∥, and Jonathan P. Schneck‡§∥ †Department of Biomedical Engineering, ‡Institute for Nanobiotechnology, §Institute for Cell Engineering, and ∥Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States

Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis

Savola et al.
Nature Communications
Papers
June 2017
immuneAccess
Authors and Affiliates
P. Savola1,2, T. Kelkka1,2, H.L. Rajala1, A. Kuuliala3, K. Kuuliala3, S. Eldfors4, P. Ellonen4, S. Lagstrom4, M. Lepisto4, T. Hannunen4, E.I. Andersson1, R.K. Khajuria1, T. Jaatinen5, R. Koivuniemi6, H. Repo3, J. Saarela4, K. Porkka1, M. Leirisalo-Repo6, & S. Mustjoki1,2 1Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Centre, Haartmaninkatu 8, FIN-00290 Helsinki, Finland. 2Department of Clinical Chemistry and Hematology, University of Helsinki, Haartmaninkatu 8, FIN-00290 Helsinki, Finland. 3Bacteriology and Immunology, Medicum, University of Helsinki, Haartmaninkatu 3, FIN-00290 Helsinki, Finland. 4Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Tukholmankatu 8, FIN-00290 Helsinki, Finland. 5Histocompatibility Testing Laboratory, Finnish Red Cross Blood Service, Kivihaantie 7, FIN-00310 Helsinki, Finland. 6Department of Rheumatology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, FIN-00290 Helsinki, Finland.

Fractionated radiation therapy stimulates anti-tumor immunity mediated by both resident and infiltrating polyclonal T-cell populations when combined with PD1 blockade

Dovedi et al.
Clinical Cancer Research
Papers
May 2017
immuneAccess
Authors and Affiliates
Simon J. Dovedi1,2, Eleanor J. Cheadle1, Amy L. Popple1, Edmund Poon2, Michelle Morrow2, Ross Stewart2, Erik C. Yusko3, Catherine M. Sanders3, Marissa Vignali3, Ryan O. Emerson3, Harlan S. Robins4, Robert W. Wilkinson2, Jamie Honeychurch1, Timothy M. Illidge1 1Targeted Therapy Group, Targeted Therapy Group, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, Christie Hospital, Manchester Academic Health Sciences Centre, United Kingdom. 2MedImmune Ltd, Granta Park, Cambridge, United Kingdom. 3Adaptive Biotechnologies, Seattle, Washington, United States of America. 4Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.