Therapeutic Area: Oncology

T-cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death-ligand 1 expression in patients with soft tissue sarcomas

Pollack et al.
Cancer
Papers
March 2017
Authors and Affiliates
Seth M. Pollack, MD1,2; Qianchuan He, PhD1,3; Jennifer H. Yearley, PhD4; Ryan Emerson, PhD5; Marissa Vignali, PhD5; Yuzheng Zhang, MA1,3; Mary W. Redman, PhD1; Kelsey K. Baker, MA1; Sara Cooper, MS1; Bailey Donahue, BS1; Elizabeth T. Loggers, MD, PhD1,2; Lee D. Cranmer, MD, PhD1,2; Matthew B. Spraker, MD, PhD6; Y. David Seo, MD7; Venu G. Pillarisetty, MD7; Robert W. Ricciotti, MD8; Benjamin L. Hoch, MD8; Terrill K. McClanahan, PhD4; Erin Murphy, BS4; Wendy M. Blumenschein, BA4; Steven M. Townson, PhD4; Sharon Benzeno, PhD5; Stanley R. Riddell, MD, PhD1,2,9; and Robin L. Jones, MD1,2,10 1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; 2Department of Medicine, University of Washington, Seattle, Washington; 3Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; 4Merck & Co., Inc. Kenilworth New Jersey; 5Adaptive Biotechnologies Corporation, Seattle, Washington; 6Department of Radiation Oncology, University of Washington, Seattle, Washington; 7Department of Surgery, University of Washington, Seattle, Washington; 8Department of Pathology, University of Washington, Seattle, Washington; 9Institute for Advanced Study, Technical University of Munich, Munich, Germany; 10Royal Marsden Hospital and Institute of Cancer Research, London.

Neutrophils dominate the immune cell composition in non-small cell lung cancer

Kargl et al.
Nature Communications
Papers
February 2017
immuneAccess
Authors and Affiliates
Julia Kargl1,2, Stephanie E. Busch1, Grace H.Y. Yang1, Kyoung-Hee Kim1, Mark L. Hanke1, Heather E. Metz1, Jesse J. Hubbard1, Sylvia M. Lee1, David K. Madtes1,3, Martin W. McIntosh4 & A. McGarry Houghton1,3,5 1Clinical Research Division, Seattle, Washington 98109, USA. 2Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitaetsplatz 4, Graz 8010, Austria. 3Division of Pulmonary and Critical Care Medicine, University of Washington, Campus Box 356522, Seattle, Washington 98195-6522, USA. 4Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, Washington 98109, USA. 5Human Biology Division, Seattle, Washington 98109, USA

Identification of patient-specific and tumor-shared T cell receptor sequences in renal cell carcinoma patients

Massa et al.
Oncotarget
Papers
February 2017
Authors and Affiliates
Chiara Massa1, Harlan Robins2, Cindy Desmarais2, Dagmar Riemann1, Corinna Fahldieck1, Paolo Fornara3, Barbara Seliger1 1Institute of Medical Immunology, Martin Luther University Halle-Wittenberg, 06112 Halle (Saale), Germany 2Adaptive Biotechnologies Corp, 98102 Seattle (WA), USA 3Clinic of Urology, Martin Luther University Halle-Wittenberg, 06112 Halle (Saale), Germany

3D: diversity, dynamics, differential testing – a proposed pipeline for analysis of next-generation sequencing T cell repertoire data

Zhang et al.
BMC Bioinformatics
Papers
February 2017
Authors and Affiliates
Li Zhang1,3, Jason Cham2, Alan Paciorek3, James Trager4, Nadeem Sheikh5, and Lawrence Fong2 1Division of Hematology and Oncology, Department of Medicine, UCSF Helen Diller Family Comprehensive Cancer Center, 550 16th Street, 6th Floor, UCSF Box 0981, San Francisco, CA 94158, USA. 2Division of Hematology and Oncology, Department of Medicine, University of California, Room HSE301, UCSF Box 1270, 513 Parnassus Ave, San Francisco, CA 94143-1270, USA. 3Department of Epidemiology and Biostatistics, University of California, San Francisco, 550 16th Street, 6th Floor, UCSF Box 0981, San Francisco, CA 94158, USA. 4Research and Development, Nkarta, Inc, 329 Oyster Point Blvd, South San Francisco, CA 94080, USA. 5Department of Research - Translational Biology, Dendreon Pharmaceuticals Inc, 1208 Eastlake Ave E, Seattle, WA 98102, USA.

Tracking the fate and origin of clinically relevant adoptively transferred CD8+ T cells in vivo

Chapuis et al.
Papers
Science Immunology
February 2017
Authors and Affiliates
Aude G. Chapuis,1 Cindy Desmarais,2 Ryan Emerson,2 Thomas M. Schmitt,1 Kendall C. Shibuya,1 Ivy P. Lai,1 Felecia Wagener,1 Jeffrey Chou,1 Ilana M. Roberts,1 David G. Coffey,1 Edus H. Warren,1 Harlan Robins,1,2 Philip D. Greenberg,1,3 Cassian Yee1 1Program in Immunology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA. 2Adaptive Biotechnologies, Suite 200, 1551 Eastlake Avenue North, Seattle, WA 98103, USA. 3Department of Immunology, University of Washington, South Lake Union, Building E, 750 Republican Street, Seattle, WA 98109, USA.

PD-1 blockade modulates chimeric antigen receptor (CAR)–modified T cells: refueling the CAR

Chong et al.
Blood
Papers
February 2017
Authors and Affiliates
Elise A. Chong,1 J. Joseph Melenhorst,2 Simon F. Lacey,2 David E. Ambrose,2 Vanessa Gonzalez,2 Bruce L. Levine,2 Carl H. June,2 and Stephen J. Schuster1 1Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; and 2Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Landscape of tumor-infiltrating T cell repertoire of human cancers

Li et al.
Nature Genetics
Papers
February 2017
immuneAccess
Authors and Affiliates
Bo Li1,2, Taiwen Li1,3, Jean-Christophe Pignon4, Binbin Wang5, Jinzeng Wang5, Sachet Shukla6, Ruoxu Dou7, Qianming Chen3, F. Stephen Hodi8, Toni K. Choueiri9, Catherine Wu6, Nir Hacohen10, Sabina Signoretti4, Jun S. Liu2, and X. Shirley Liu1,2 1Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA, USA, 2Department of Statistics, Harvard University, Boston, MA, USA, 3State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China, 4Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA, 5School of Life Science and Technology, Tongji University, China, Shanghai, China, 6Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA, 7Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, 8Center for ImmunoOncology, Harvard Medical School, Boston, MA, USA, 9Kidney Cancer Center, Dana Farber Cancer Institute, Boston, MA, USA, 10Center for Cancer Immunotherapy, Massachusetts General Hospital, Boston, MA, USA

Tumor-Infiltrating Merkel Cell Polyomavirus-Specific T Cells Are Diverse and Associated with Improved Patient Survival

Miller et al.
Cancer Immunology Research
Papers
February 2017
immuneAccess
Authors and Affiliates
Natalie J. Miller1, Candice D. Church1, Lichun Dong2, David Crispin3, Matthew P. Fitzgibbon3, Kristina Lachance1, Lichen Jing2, Michi Shinohara1, Ioannis Gavvovidis4,5, Gerald Willimsky5,6, Martin McIntosh3, Thomas Blankenstein4,5,7, David M. Koelle2,8,9, and Paul Nghiem1 1Dermatology/Medicine/Pathology, University of Washington, Seattle, Washington. 2Department of Medicine/Laboratory Medicine/Global Health, University of Washington, Seattle, Washington. 3Fred Hutchinson, Public Health Sciences Division, Seattle, Washington. 4Molecular Immunology and Gene Therapy, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany. 5Institute of Immunology, Charit e, Berlin, Germany. 6German Cancer Research Center (DKFZ), Heidelberg, Germany. 7Berlin Institute of Health, Berlin, Germany. 8Fred Hutchinson, Vaccine and Infectious Disease Division, Seattle, Washington. 9Benaroya Research Institute, Seattle, Washington.

Ibrutinib Therapy Increases T Cell Repertoire Diversity in Patients with Chronic Lymphocytic Leukemia

Yin et al.
Journal of Immunology
Papers
January 2017
Authors and Affiliates
Qingsong Yin,*,†,1 Mariela Sivina,*,1 Harlan Robins,‡,x Erik Yusko,‡ Marissa Vignali,‡ Susan O’Brien,* Michael J. Keating,* Alessandra Ferrajoli,* Zeev Estrov,* Nitin Jain,* William G. Wierda,* and Jan A. Burger* *Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77230; †Department of Leukemia, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Henan Institute of Hematology, Zhengzhou, Henan 450009, China; ‡Adaptive Biotechnologies, Seattle, WA 98102; and xFred Hutchinson Cancer Research Center, Seattle, WA 98109

Evolution of Neoantigen Landscape During Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

Anagnostou et al.
Cancer Discovery
Papers
January 2017
Authors and Affiliates
Valsamo Anagnostou1,2*, Kellie N. Smith1,2, Patrick M. Forde1,2, Noushin Niknafs3, Rohit Bhattacharya3, James White1, Theresa Zhang4, Vilmos Adleff1, Jillian Phallen1, Neha Wali1, Carolyn Hruban1, Violeta B. Guthrie3, Kristen Rodgers5, Jarushka Naidoo1,2, Hyunseok Kang1, William Sharfman1, Christos Georgiades6, Franco Verde7, Peter Illei1,8, Qing Kay Li8, Edward Gabrielson1,8, Malcolm V. Brock1,5, Cynthia A. Zahnow1, Stephen B. Baylin1, Rob Scharpf1, Julie R. Brahmer1,2, Rachel Karchin3, Drew M. Pardoll1,2 and Victor E. Velculescu1,2,3,8 1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA, 2The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA 3Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland 21204, USA, 4Personal Genome Diagnostics, Baltimore, MD 21224, USA, 5Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA, 6Department of Radiology and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA, 7Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA, 8Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA