Therapeutic Area: Oncology

Ultra-deep T-cell receptor sequencing reveals the complexity and intratumour heterogeneity of T-cell clones in renal cell carcinomas

Marco et al.
Journal of Pathology
Papers
December 2013
Authors and Affiliates
Marco Gerlinger,1,2 Sergio A Quezada,3 Karl S Peggs,3 Andrew JS Furness,3,4 Rosalie Fisher,4 Teresa Marafioti,5Vishvesh H Shende,5 Nicholas McGranahan,1,6 Andrew J Rowan,1 Steven Hazell,4 David Hamm,7 Harlan S Robins,8Lisa Pickering,4 Martin Gore,4 David L Nicol,4 James Larkin,4 and Charles Swanton1,3 1Cancer Research UK, London Research Institute, UK, 2Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, London, UK, 3UCL Cancer Institute, London, UK, 4Royal Marsden Hospital, London, UK, 5Departments of Pathology and Histopathology, University College Hospital, London, UK, 6Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, UK, 7Adaptive Biotechnologies, Seattle, WA, USA, 8Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Digital genomic quantification of tumor-infiltrating lymphocytes

Robins et al.
Papers
Science Translational Medicine
December 2013
Authors and Affiliates
Robins HS1, Ericson NG, Guenthoer J, O’Briant KC, Tewari M, Drescher CW, Bielas JH. 1Herbold Computational Biology Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

High-throughput sequencing of T cell receptors reveals a homogeneous repertoire of tumor-infiltrating lymphocytes in ovarian cancer

Emerson et al.
Journal of Pathology
Papers
December 2013
immuneAccess
Authors and Affiliates
Ryan O. Emerson,#1 Anna M. Sherwood,#1 Mark J. Rieder,1 Jamie Guenthoer,2 David W. Williamson,1 Christopher S. Carlson,2 Charles W. Drescher,2,3 Muneesh Tewari,2,3 Jason H. Bielas,2 and Harlan S. Robins2 1Adaptive Biotechnologies, Seattle, WA. 2Fred Hutchinson Cancer Research Center, Seattle, WA. 3University of Washington School of Medicine, Seattle, WA. #Contributed equally.

Peripheral blood mononuclear cells of patients with breast cancer can be reprogrammed to enhance anti-HER-2/neu reactivity and overcome myeloid-derived suppressor cells

Payne et al.
Breast Cancer Research and Treatment
Papers
November 2013
Authors and Affiliates
Kyle K Payne,1 Christine K Zoon,1 Wen Wan,1 Khin Marlar,2 Rebecca C Keim,1 Mehrab Nasiri Kenari,2 Latif Kazim,2Harry D Bear,1 and Masoud H Manjili1 1Virginia Commonwealth University - Massey Cancer Center, Richmond, VA, USA, 2Roswell Park Cancer Institute, Buffalo, NY, USA.

Peripheral T-cell lymphoma emerging in a patient with aggressive polymyositis: molecular evidence for neoplastic transformation of an oligoclonal T-cell infiltrate

Tsankova et al.
Acta Neuropathologica
Papers
October 2013
Authors and Affiliates
Tsankova NM1, Bevan C, Jobanputra V, Ko YC, Mayer EW, Lefkowitch JH, Mansukhani M, Rowland LP, Bhagat G, Tanji K. 1 Division of Neuropathology, Department of Pathology and Cell Biology, Columbia University Medical Center and New York Presbyterian Hospital, 630 W. 168th Street, PH15-124, New York, 10032, USA, nmt2111@columbia.edu.

BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes

Cooper et al.
OncoImmunology
Papers
October 2013
Authors and Affiliates
Zachary A Cooper, 1 , 2 Dennie T Frederick, 3 Vikram R Juneja, 4 , 5 Ryan J Sullivan, 6 , 7 Donald P Lawrence, 6 ,7 Adriano Piris, 7 , 8 Arlene H Sharpe, 4 David E Fisher, 7 , 9 Keith T Flaherty, 6 , 7 and Jennifer A Wargo 1 , 2 1Department of Surgical Oncology; University of Texas MD Anderson Cancer Center; Houston, TX USA 2Department of Genomic Medicine; University of Texas MD Anderson Cancer Center; Houston, TX USA 3Division of Surgical Oncology; Massachusetts General Hospital; Boston, MA USA 4Department of Microbiology and Immunobiology; Harvard Medical School; Boston, MA USA 5Division of Health Sciences and Technology; Massachusetts Institute of Technology; Cambridge, MA USA 6Division of Medical Oncology; Massachusetts General Hospital; Boston, MA USA 7Harvard Medical School; Boston, MA USA 8Division of Dermatophathology; Massachusetts General Hospital; Boston, MA USA 9Division of Dermatology; Massachusetts General Hospital; Boston, MA USA

Tumor-infiltrating lymphocytes in colorectal tumors display a diversity of T cell receptor sequences that differ from the T cells in adjacent mucosal tissue

Sherwood et al.
Cancer Immunology and Immunotherapy
Papers
September 2013
immuneAccess
Authors and Affiliates
Sherwood A1, Emerson R1, Scherer D2, Habermann N2, Buck K2, Staffa J2, Desmarais C1, Halama N3, Jaeger D3, Schirmacher P, Herpel E, Kloor M, Ulrich A2, Schneider M, Ulrich CM, Robins H1. 1Adaptive Biotechnologies, 1551 Eastlake Ave, Seattle, WA 98102, USA. 2Department of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, 69120 Heidelberg, Germany. 3National Center for Tumor Diseases, Medical Oncology, University of Heidelberg Medical Center, Heidelberg, Germany & German Cancer Consortium (DKTK), Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.

Allelic Exclusion and Peripheral Reconstitution by TCR Transgenic T cells Arising from Transduced Human Hematopoietic Stem/Progenitor Cells

Giannoni et al.
Molecular Therapy
Papers
May 2013
Authors and Affiliates
Giannoni F1, Hardee CL, Wherley J, Gschweng E, Senadheera S, Kaufman ML, Chan R, Bahner I, Gersuk V, Wang X, Gjertson D, Baltimore D, Witte ON, Economou JS, Ribas A, Kohn DB. 1Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, USA.